Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cannabis Use Disorder: early-phase trial registry
25 of 35 indexed Cannabis Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #435 of 28,707 conditions by registered trial count.
35 US clinical trials · 25 currently recruiting · #435 of 28,707 conditions by registered trial count
Cannabis Use Disorder: 35 US clinical trials tracked, 25 recruiting.
Cannabis Use Disorder is the subject of 35 registered US clinical trials on ClinicalTrials.gov, 25 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 6 of these trials.
Enrollment posture brief
Registry condition cannabis-use-disorder
OPEN 25 | RECR 71% | LATE 4 | EARLY 17 | RANK #435 | SPON 6
Volume-matched condition peers
Nearest open-share peer: ACL Tear (71% recruiting · 7 trials)
Cannabis Use Disorder lists 25 open slots (71% of 35 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cannabis Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cannabis Use Disorder is recruiting above its size-band peers.
25 of 35 indexed trials (71.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Cannabis Use Disorder research.
Medical University of South Carolina accounts for 6 of 35 trials (17.1%). 20 distinct sponsors appear on at least one study for this condition label.
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Typical Cannabis Use Disorder enrolment sits around 80 participants.
Median target enrolment is 80 among the 35 trials that report a genuine target (sentinel values excluded). 20 of those (57.1%) plan for fewer than 100 participants.
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Cannabis Use Disorder research is mostly interventional.
33 interventional and 2 observational studies make up this index (94.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
35 total, page 1 of 1
Integrated Treatment for Enhancing Growth in Recovery During Adolescence
Massachusetts General Hospital
NCT06395467
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
University of Miami
NCT05453513
SV2 PET Imaging With [11C]APP311
Yale University
NCT03995121
Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans
Yale University
NCT06058702
Cannabis-Tobacco Co-Use Treatment Study
Medical University of South Carolina
NCT06883162
A Study of Cannabidiol in Young Adult Cannabis Users
University of Colorado, Denver
NCT06569394
Study of Oral Fluid Testing Approach
Boston Children's Hospital
NCT06891235
Cannabis Reduction and Functional Outcomes
Medical University of South Carolina
NCT07218471
Longitudinal Outpatient Treatment for Cannabis Use Disorder
University of Colorado, Boulder
NCT06107062
SCORE Emerging Adult Cannabis Use & Stress
Medical University of South Carolina
NCT05885542
Stress and Pain in People Living With HIV
Yale University
NCT06784908
Cannabidiol and Cannabis Concentrate Users
University of Colorado, Denver
NCT06575751
Evaluation of a Brief Computerized and Smart Phone-based Intervention for Stress in Regular Cannabis Users
Florida State University
NCT06085222
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Massachusetts General Hospital
NCT06878859
Neuroimaging of Adolescent Cannabis Use Treatment
Indiana University
NCT07340554
Mitigating PTSD-CUD After Sexual Assault
University of Nevada, Las Vegas
NCT05989841
Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)
University of Minnesota
NCT06124846
A Brief Intervention for Cannabis Use
Medical University of South Carolina
NCT06395389
SV2A Density Cannabis Use Disorder
Yale University
NCT05472818
RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative
NYU Langone Health
NCT07184983
Cannabinoids and Biological Reactivity to Stress
Florida State University
NCT06430580
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
University of Colorado, Denver
NCT06446479
Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)
Massachusetts General Hospital
NCT06584942
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
Trustees of Dartmouth College
NCT06920238
Psilocybin-assisted Treatment for Cannabis Use Disorder
Johns Hopkins University
NCT06660381
Breathwork-assisted Treatment for Cannabis Use Disorder
Elias Dakwar
NCT05219825
UH3 Varenicline for Cannabis Use Disorder
Medical University of South Carolina
NCT03980561
Adaptive Treatment for Adolescent Cannabis Use Disorders
UConn Health
NCT01656707
Bupropion for ADHD in Adolescents With Substance Use Disorder
University of Colorado, Denver
NCT00936299
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
Stanford University
NCT03144232
Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders
Louisiana State University and A&M College
NCT01875796
A Teleheath tDCS Approach to Decrease Cannabis Use
NYU Langone Health
NCT05005013
Treatment of Cannabis Use Disorder Among Adults With Comorbid Attention-Deficit/Hyperactivity Disorder
New York State Psychiatric Institute
NCT02803229
Reducing Cannabis Overuse With Prazosin
VA Puget Sound Health Care System
NCT04721353
Progesterone for Cannabis Withdrawal
Medical University of South Carolina
NCT03430050
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Cannabis Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cannabis Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cannabis Use Disorder page
35 registered trials, 25 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 25 Cannabis Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical University of South Carolina sponsors the most Cannabis Use Disorder trials on record, review their full trial history before evaluating a specific study. See Medical University of South Carolina's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cannabis Use Disorder condition card totals 35 registered trials; most-linked intervention Placebo; top US site state South Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.