Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Cannabis Use Disorder

Open-data reference.

35 US clinical trials · 25 currently recruiting

Active & Recent Trials

RECRUITING NA 294 participants

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

Massachusetts General Hospital

NCT06395467

RECRUITING NA 280 participants

The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

University of Miami

NCT05453513

RECRUITING 250 participants

SV2 PET Imaging With [11C]APP311

Yale University

NCT03995121

RECRUITING Phase 1 215 participants

Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans

Yale University

NCT06058702

RECRUITING Phase 3 200 participants

Cannabis-Tobacco Co-Use Treatment Study

Medical University of South Carolina

NCT06883162

RECRUITING Phase 2 200 participants

A Study of Cannabidiol in Young Adult Cannabis Users

University of Colorado, Denver

NCT06569394

RECRUITING 200 participants

Study of Oral Fluid Testing Approach

Boston Children's Hospital

NCT06891235

RECRUITING NA 176 participants

Cannabis Reduction and Functional Outcomes

Medical University of South Carolina

NCT07218471

RECRUITING Phase 2 165 participants

Longitudinal Outpatient Treatment for Cannabis Use Disorder

University of Colorado, Boulder

NCT06107062

RECRUITING Phase 1 148 participants

SCORE Emerging Adult Cannabis Use & Stress

Medical University of South Carolina

NCT05885542

RECRUITING NA 120 participants

Stress and Pain in People Living With HIV

Yale University

NCT06784908

RECRUITING Phase 2 120 participants

Cannabidiol and Cannabis Concentrate Users

University of Colorado, Denver

NCT06575751

RECRUITING NA 80 participants

Evaluation of a Brief Computerized and Smart Phone-based Intervention for Stress in Regular Cannabis Users

Florida State University

NCT06085222

RECRUITING NA 80 participants

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Massachusetts General Hospital

NCT06878859

RECRUITING NA 80 participants

Neuroimaging of Adolescent Cannabis Use Treatment

Indiana University

NCT07340554

RECRUITING Phase 1 68 participants

Mitigating PTSD-CUD After Sexual Assault

University of Nevada, Las Vegas

NCT05989841

RECRUITING NA 64 participants

Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

University of Minnesota

NCT06124846

RECRUITING NA 62 participants

A Brief Intervention for Cannabis Use

Medical University of South Carolina

NCT06395389

RECRUITING Early Phase 1 51 participants

SV2A Density Cannabis Use Disorder

Yale University

NCT05472818

RECRUITING NA 46 participants

RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative

NYU Langone Health

NCT07184983

RECRUITING Early Phase 1 36 participants

Cannabinoids and Biological Reactivity to Stress

Florida State University

NCT06430580

RECRUITING Phase 2 28 participants

Effects of THC on Alcohol Consumption and Neural Correlates of Reward

University of Colorado, Denver

NCT06446479

RECRUITING Phase 4 20 participants

Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)

Massachusetts General Hospital

NCT06584942

RECRUITING Phase 1 15 participants

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

Trustees of Dartmouth College

NCT06920238

RECRUITING Phase 1 12 participants

Psilocybin-assisted Treatment for Cannabis Use Disorder

Johns Hopkins University

NCT06660381

ACTIVE NOT RECRUITING NA 10 participants

Breathwork-assisted Treatment for Cannabis Use Disorder

Elias Dakwar

NCT05219825

COMPLETED Phase 2 174 participants

UH3 Varenicline for Cannabis Use Disorder

Medical University of South Carolina

NCT03980561

COMPLETED NA 172 participants

Adaptive Treatment for Adolescent Cannabis Use Disorders

UConn Health

NCT01656707

COMPLETED Phase 4 105 participants

Bupropion for ADHD in Adolescents With Substance Use Disorder

University of Colorado, Denver

NCT00936299

COMPLETED Phase 2 72 participants

A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder

Stanford University

NCT03144232

COMPLETED Phase 1 68 participants

Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders

Louisiana State University and A&M College

NCT01875796

COMPLETED Phase 2 52 participants

A Teleheath tDCS Approach to Decrease Cannabis Use

NYU Langone Health

NCT05005013

COMPLETED Phase 2 33 participants

Treatment of Cannabis Use Disorder Among Adults With Comorbid Attention-Deficit/Hyperactivity Disorder

New York State Psychiatric Institute

NCT02803229

COMPLETED Phase 4 11 participants

Reducing Cannabis Overuse With Prazosin

VA Puget Sound Health Care System

NCT04721353

COMPLETED Early Phase 1 8 participants

Progesterone for Cannabis Withdrawal

Medical University of South Carolina

NCT03430050

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 8
Phase 3 1
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cannabis Use Disorder Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Cannabis Use Disorder, and 25 of those are currently open to recruitment — roughly 71% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cannabis Use Disorder shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 17 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cannabis Use Disorder is led by Medical University of South Carolina with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cannabis Use Disorder?

PlainTrial tracks 35 US clinical trials for Cannabis Use Disorder, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cannabis Use Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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