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NCT06123338 · ClinicalTrials.gov registry record · Phase 2
A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
A Phase 2 study of Esophageal Cancer and Gastric Adenocarcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 49
- Enrollment target
- 10
- Study locations
NCT06123338: Recruiting Phase 2 study of Esophageal Cancer and Gastric Adenocarcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT06123338 is a Phase 2 study of Esophageal Cancer and Gastric Adenocarcinoma that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 49 participants, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (90% lower). The trial reports 10 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06123338, a Phase 2 study of Esophageal Cancer and Gastric Adenocarcinoma, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 49 participants
- Enrollment target
- 10
- Study locations
Study Summary
The purpose of this study to find out whether adding trastuzumab and pembrolizumab to standard chemotherapy is an effective treatment for resectable HER2+ esophagogastric cancer.
Primary Outcome
EFS is defined as the time from start of treatment to time of disease progression, recurrence, or death, whichever occurs first.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Trastuzumab
- DRUG Capecitabine
- DRUG Oxaliplatin
- DRUG 5-Fluorouracil
Study Locations (10)
New York
- Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Massachusetts
- Massachusetts General Hospital (Data Collection Only) - Boston
Pennsylvania
- University of Pennsylvania (Data Collection Only) - Philadelphia
Texas
- MD Anderson Cancer Center (Data Collection Only) - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2024-02-01 |
| Est. Completion | 2027-11-30 |
| Phase | Phase 2 |
What NCT06123338 shows while recruiting
NCT06123338 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Esophageal Cancer appearing as the primary indexed condition, and to 5 interventions - of which Pembrolizumab is the first listed.
NCT06123338 lists 10 locations in 5 states (New York, New Jersey, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT06123338 about?
NCT06123338 is a clinical study titled "A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer". The purpose of this study to find out whether adding trastuzumab and pembrolizumab to standard chemotherapy is an effective treatment for resectable HER2+ esophagogastric cancer.
What is the current status of trial NCT06123338?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 49 participants. The study started on 2024-02-01. Estimated completion is 2027-11-30.
What conditions does trial NCT06123338 study?
This clinical trial studies the following conditions: Esophageal Cancer, Gastric Adenocarcinoma, HER2 Gene Mutation.
What interventions are being tested in trial NCT06123338?
The interventions under investigation include: Pembrolizumab (DRUG), Trastuzumab (DRUG), Capecitabine (DRUG), Oxaliplatin (DRUG), 5-Fluorouracil (DRUG).
Who is sponsoring clinical trial NCT06123338?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06123338 being conducted?
This trial has 10 study locations across Massachusetts, New Jersey, New York, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06123338's enrollment target sits among peer trials
49 78th of 123 higher than 46 of 123 other Esophageal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Esophageal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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