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NCT07454642 · ClinicalTrials.gov registry record · Phase 1
AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors
A Phase 1 study of Gastric Adenocarcinoma and Cervical Adenocarcinoma, sponsored by Avacta Life Sciences.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 144
- Enrollment target
- 2
- Study locations
NCT07454642: Recruiting Phase 1 study of Gastric Adenocarcinoma and Cervical Adenocarcinoma, sponsored by Avacta Life Sciences.
NCT07454642 is a Phase 1 study of Gastric Adenocarcinoma and Cervical Adenocarcinoma that is actively recruiting participants, run by Avacta Life Sciences. The registered enrollment target is 144 participants, below the 242-participant average among 47 other Gastric Adenocarcinoma trials with a reported enrollment target (40% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07454642, a Phase 1 study of Gastric Adenocarcinoma and Cervical Adenocarcinoma, is actively recruiting participants, sponsored by Avacta Life Sciences.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 144 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a first-in-human (FIH), Phase 1 open-label, multicenter dose escalation study investigating AVA6103 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumors that are likely to be FAP positive. The study consists of an initial Phase 1a dose escalation portion and a subsequent Phase 1b dose expansion portion upon completion of the dose escalation portion.
Primary Outcome
Incidence and severity of treatment-emergent (TE) and treatment-related adverse events (TRAEs) and Serious Adverse Events (SAEs).
Conditions Studied
Interventions
- DRUG AVA6103
Study Locations (2)
Texas
- NEXT Oncology - Irving
Virginia
- NEXT Oncology Virginia - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 144 participants |
| Start Date | 2026-03 |
| Est. Completion | 2030-06 |
| Phase | Phase 1 |
What NCT07454642 shows while recruiting
NCT07454642 is an interventional study that assigns participants to a tested intervention. The registered 144 participants enrollment target is mid-sized for trials with a published cap, below the 242-participant average among 47 other Gastric Adenocarcinoma trials with a reported enrollment target (40% lower).
The record links to 7 conditions, with Gastric Adenocarcinoma appearing as the primary indexed condition, and to 1 intervention - of which AVA6103 is the first listed.
NCT07454642 reports a single indexed study location in Texas, Virginia.
Frequently Asked Questions
What is clinical trial NCT07454642 about?
NCT07454642 is a clinical study titled "AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors". This is a first-in-human (FIH), Phase 1 open-label, multicenter dose escalation study investigating AVA6103 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumors that are likely to be FAP positive. The study consists of an initial Phase 1a...
What is the current status of trial NCT07454642?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 144 participants. The study started on 2026-03. Estimated completion is 2030-06.
What conditions does trial NCT07454642 study?
This clinical trial studies the following conditions: Gastric Adenocarcinoma, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, PDAC - Pancreatic Ductal Adenocarcinoma, GEJ Adenocarcinoma.
What interventions are being tested in trial NCT07454642?
The interventions under investigation include: AVA6103 (DRUG).
Who is sponsoring clinical trial NCT07454642?
This trial is sponsored by Avacta Life Sciences, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07454642 being conducted?
This trial has 2 study locations across Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Gastric Adenocarcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07454642's enrollment target sits among peer trials
144 16th of 47 higher than 32 of 47 other Gastric Adenocarcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Gastric Adenocarcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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