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NCT06756035 · ClinicalTrials.gov registry record · Phase 1
CT-95 in Advanced Cancers Associated With Mesothelin Expression
A Phase 1 study of Epithelial Ovarian Cancer and Cholangiocarcinoma Non-resectable, sponsored by Context Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 70
- Enrollment target
- 8
- Study locations
NCT06756035 is a Phase 1 study of Epithelial Ovarian Cancer and Cholangiocarcinoma Non-resectable that is actively recruiting participants, run by Context Therapeutics. The registered enrollment target is 70 participants, below the 209-participant average among 41 other Epithelial Ovarian Cancer trials with a reported enrollment target (67% lower). The trial reports 8 study locations across 7 states.
The verdict
NCT06756035, a Phase 1 study of Epithelial Ovarian Cancer and Cholangiocarcinoma Non-resectable, is actively recruiting participants, sponsored by Context Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 70 participants
- Enrollment target
- 8
- Study locations
Study Summary
This is a Phase 1a/1b open-label, dose escalation study to evaluate the safety and efficacy of CT-95 (study drug), a humanized T cell engaging bispecific antibody targeting Mesothelin, in subjects with advanced solid tumors associated with Mesothelin expression.
Conditions Studied
Interventions
- DRUG CT-95
Study Locations (8)
Texas
- Context Investigational Site - San Antonio
- Context Investigational Site - San Antonio
Colorado
- Context Investigational Site - Denver
Illinois
- Context Investigational Site - Chicago
Michigan
- Context Investigational Site - Grand Rapids
New Jersey
- Context Investigational Site - Hackensack
Pennsylvania
- Context Investigational Site - Philadelphia
Tennessee
- Context Investigational Site - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2025-03-31 |
| Est. Completion | 2028-12 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06756035
The ClinicalTrials.gov registry entry for NCT06756035 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 209-participant average among 41 other Epithelial Ovarian Cancer trials with a reported enrollment target (67% lower). The listed sponsor is Context Therapeutics, which has 3 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Epithelial Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention - of which CT-95 is the first listed.
NCT06756035 reports 8 study locations spanning 7 distinct geographic areas - top geographies include Texas, Colorado, Illinois.
Frequently Asked Questions
What is clinical trial NCT06756035 about?
NCT06756035 is a clinical study titled "CT-95 in Advanced Cancers Associated With Mesothelin Expression". This is a Phase 1a/1b open-label, dose escalation study to evaluate the safety and efficacy of CT-95 (study drug), a humanized T cell engaging bispecific antibody targeting Mesothelin, in subjects with advanced solid tumors associated with Mesothelin expression.
What is the current status of trial NCT06756035?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2025-03-31. Estimated completion is 2028-12.
What conditions does trial NCT06756035 study?
This clinical trial studies the following conditions: Epithelial Ovarian Cancer, Cholangiocarcinoma Non-resectable, Lung Adenocarcinoma Metastatic, Mesothelin-Expressing Tumors, Malignant Pleural Mesothelioma, Advanced.
What interventions are being tested in trial NCT06756035?
The interventions under investigation include: CT-95 (DRUG).
Who is sponsoring clinical trial NCT06756035?
This trial is sponsored by Context Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06756035 being conducted?
This trial has 8 study locations across Colorado, Illinois, Michigan, New Jersey, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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