Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study of ZN-c3 in Patients With Ovarian Cancer

NCT04516447 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.

Interventions

  • DRUG Carboplatin
  • DRUG Paclitaxel
  • DRUG Gemcitabine
  • DRUG ZN-c3
  • DRUG Pegylated liposomal doxorubicin

Study Locations (20)

Other

  • Site 1001 — Banja Luka
  • Site 1002 — Sarajevo
  • Site 1003 — Tuzla
  • Site 1202 — Panagyurishte
  • Site 1201 — Sofia
  • Site 1401 — Tbilisi

Queensland

  • Site 2707 — South Brisbane
  • Site 2708 — Sunshine Coast

Victoria

  • Site 2716 — Melbourne
  • Site 2706 — Melbourne

Colorado

  • Site 0264 — Aurora

Massachusetts

  • Site 0104 — Boston

Missouri

  • Site 0111 — St Louis

New York

  • Site 0173 — New York

North Carolina

  • Site 0259 — Durham

Trial Details

FieldValue
Enrollment Target 140 participants
Start Date 2020-10-26
Est. Completion 2027-02-28
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04516447

The ClinicalTrials.gov registry entry for NCT04516447 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 140 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Solid Tumor appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04516447 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Queensland, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04516447 about?

NCT04516447 is a clinical study titled "A Study of ZN-c3 in Patients With Ovarian Cancer". This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.

What is the current status of trial NCT04516447?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 140 participants. The study started on 2020-10-26. Estimated completion is 2027-02-28.

What conditions does trial NCT04516447 study?

This clinical trial studies the following conditions: Solid Tumor, Fallopian Tube Cancer, Epithelial Ovarian Cancer, Peritoneal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04516447?

The interventions under investigation include: Carboplatin (DRUG), Paclitaxel (DRUG), Gemcitabine (DRUG), ZN-c3 (DRUG), Pegylated liposomal doxorubicin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04516447?

This trial is sponsored by K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04516447 being conducted?

This trial has 20 study locations across Colorado, Massachusetts, Missouri, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial