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NCT06469281 · ClinicalTrials.gov registry record · Phase 1
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers
A Phase 1 study of Fallopian Tube Cancer and Epithelial Ovarian Cancer, sponsored by Regeneron Pharmaceuticals.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 90
- Enrollment target
- 5
- Study locations
NCT06469281 is a Phase 1 study of Fallopian Tube Cancer and Epithelial Ovarian Cancer that is actively recruiting participants, run by Regeneron Pharmaceuticals. The registered enrollment target is 90 participants, below the 255-participant average among 85 other Fallopian Tube Cancer trials with a reported enrollment target (65% lower). The trial reports 5 study locations across 5 states.
The verdict
NCT06469281, a Phase 1 study of Fallopian Tube Cancer and Epithelial Ovarian Cancer, is actively recruiting participants, sponsored by Regeneron Pharmaceuticals.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 90 participants
- Enrollment target
- 5
- Study locations
Study Summary
This study is researching an experimental CAR T cell therapy called 27T51, referred to as study drug. The study drug is a MUC16 targeting immune cell therapy focused on adult female participants with recurrent or difficult to treat epithelial ovarian, primary peritoneal or fallopian tube cancer. This study has two (2) major parts: Phase 1a Dose Escalation and Phase 1b Dose Expansion. The aim of the dose escalation part will be to test the safety of 27T51 in a small number of participants to find the highest dose given to humans without unacceptable side effects. The aim of the dose expansion part will be to test 27T51 at the established dose level(s) from the dose escalation part and may include other medications given in combination with 27T51. Information collected from this study will help researchers understand more fully whether this immune cell therapy, also known as CAR T cell therapy, can be safely used to treat solid tumors such as ovarian cancer.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Cemiplimab
- OTHER 27T51
Study Locations (5)
Massachusetts
- Massachusetts General Hospital - Boston
New Jersey
- John Theurer Cancer Center Hackensack University Medical Center - Hackensack
New York
- Roswell Park Cancer Institute - Buffalo
Pennsylvania
- UPMC Hillman Cancer Center - Pittsburgh
Utah
- LDS Hospital - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2024-08-06 |
| Est. Completion | 2030-05-27 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06469281
The ClinicalTrials.gov registry entry for NCT06469281 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 255-participant average among 85 other Fallopian Tube Cancer trials with a reported enrollment target (65% lower). The listed sponsor is Regeneron Pharmaceuticals, which has 280 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Fallopian Tube Cancer appearing as the primary indexed condition, and to 3 interventions - of which Bevacizumab is the first listed.
NCT06469281 reports 5 study locations spanning 5 distinct geographic areas - top geographies include Massachusetts, New Jersey, New York.
Frequently Asked Questions
What is clinical trial NCT06469281 about?
NCT06469281 is a clinical study titled "A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers". This study is researching an experimental CAR T cell therapy called 27T51, referred to as study drug. The study drug is a MUC16 targeting immune cell therapy focused on adult female participants with recurrent or difficult to treat epithelial ovarian, primary peritoneal or fallopian tube cancer. Th...
What is the current status of trial NCT06469281?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 90 participants. The study started on 2024-08-06. Estimated completion is 2030-05-27.
What conditions does trial NCT06469281 study?
This clinical trial studies the following conditions: Fallopian Tube Cancer, Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma.
What interventions are being tested in trial NCT06469281?
The interventions under investigation include: Bevacizumab (DRUG), Cemiplimab (DRUG), 27T51 (OTHER).
Who is sponsoring clinical trial NCT06469281?
This trial is sponsored by Regeneron Pharmaceuticals, which has 280 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06469281 being conducted?
This trial has 5 study locations across Massachusetts, New Jersey, New York, Pennsylvania, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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