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NCT02682147 · ClinicalTrials.gov registry record · Phase 4
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
A Phase 4 study of Emphysema, sponsored by Eric A. Hoffman.
- Active
- Registry status
- Phase 4
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT02682147: Active Phase 4 study of Emphysema, sponsored by Eric A. Hoffman.
NCT02682147 is a Phase 4 study of Emphysema that is active but no longer recruiting, run by Eric A. Hoffman. The registered enrollment target is 17 participants, below the 3,803-participant average among 25 other Emphysema trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02682147, a Phase 4 study of Emphysema, is active but no longer recruiting, sponsored by Eric A. Hoffman.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema
Primary Outcome
Regional heterogeneity perfused blood volume will be measured by duel energy CT scan at two time points and compared at two points, pre and post the administration of sildenafil.
Conditions Studied
Interventions
- DRUG Sildenafil
Study Locations (1)
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2017-07-10 |
| Est. Completion | 2025-05 |
| Phase | Phase 4 |
What the registry record for NCT02682147 still lists
NCT02682147 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 3,803-participant average among 25 other Emphysema trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Emphysema appearing as the primary indexed condition, and to 1 intervention - of which Sildenafil is the first listed.
NCT02682147 reports a single indexed study location in Iowa.
Frequently Asked Questions
What is clinical trial NCT02682147 about?
NCT02682147 is a clinical study titled "Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema". This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigator...
What is the current status of trial NCT02682147?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 17 participants. The study started on 2017-07-10. Estimated completion is 2025-05.
What conditions does trial NCT02682147 study?
This clinical trial studies the following conditions: Emphysema.
What interventions are being tested in trial NCT02682147?
The interventions under investigation include: Sildenafil (DRUG).
Who is sponsoring clinical trial NCT02682147?
This trial is sponsored by Eric A. Hoffman, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02682147 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Emphysema
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02682147's enrollment target sits among peer trials
17 23rd of 25 higher than 1 of 25 other Emphysema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Emphysema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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