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Prostaglandin Inhibition for Emphysema
NCT02006576 · View on ClinicalTrials.gov ↗
Study Summary
The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in improvement in measures of lung repair function.
Conditions Studied
Interventions
- DRUG 600 mg ibuprofen three times daily for 48 weeks
- OTHER Placebo three times daily
Study Locations (5)
Alabama
- University of Alabama at Birmingham — Birmingham
California
- Harbor-UCLA Medical Center — Torrance
Colorado
- National Jewish Health — Denver
Nebraska
- Univerisity of Nebraska Medical Center — Omaha
Pennsylvania
- Temple University — Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2014-01-01 |
| Est. Completion | 2018-03-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02006576
The ClinicalTrials.gov registry entry for NCT02006576 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 118 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Nebraska, which has 272 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Emphysema appearing as the primary indexed condition, and to 2 interventions — of which 600 mg ibuprofen three times daily for 48 weeks is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02006576 reports 5 study locations spanning 5 distinct geographic areas — top geographies include Alabama, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02006576 about?
NCT02006576 is a clinical study titled "Prostaglandin Inhibition for Emphysema". The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in improvement in measures of lung repair function.
What is the current status of trial NCT02006576?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 118 participants. The study started on 2014-01-01. Estimated completion is 2018-03-31.
What conditions does trial NCT02006576 study?
This clinical trial studies the following conditions: Emphysema. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02006576?
The interventions under investigation include: 600 mg ibuprofen three times daily for 48 weeks (DRUG), Placebo three times daily (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02006576?
This trial is sponsored by University of Nebraska, which has 272 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02006576 being conducted?
This trial has 5 study locations across Alabama, California, Colorado, Nebraska, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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