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NCT02006576 · ClinicalTrials.gov registry record · Phase 2
Prostaglandin Inhibition for Emphysema
A Phase 2 study of Emphysema, sponsored by University of Nebraska.
- Completed
- Registry status
- Phase 2
- Development phase
- 118
- Enrollment target
- 5
- Study locations
NCT02006576: Completed Phase 2 study of Emphysema, sponsored by University of Nebraska.
NCT02006576 is a Phase 2 study of Emphysema that has completed, run by University of Nebraska. The registered enrollment target is 118 participants, below the 3,799-participant average among 25 other Emphysema trials with a reported enrollment target (97% lower). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02006576, a Phase 2 study of Emphysema, has completed, sponsored by University of Nebraska.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 118 participants
- Enrollment target
- 5
- Study locations
Study Summary
The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in improvement in measures of lung repair function.
Primary Outcome
PGE will be measured by HPLC in alveolar fluids obtained at randomization (week 0) and again 12 weeks after randomization on emphysema subjects taking placebo and emphysema subjects taking ibuprofen to compare control group versus treatment group.
Conditions Studied
Interventions
- DRUG 600 mg ibuprofen three times daily for 48 weeks
- OTHER Placebo three times daily
Study Locations (5)
Alabama
- University of Alabama at Birmingham - Birmingham
California
- Harbor-UCLA Medical Center - Torrance
Colorado
- National Jewish Health - Denver
Nebraska
- Univerisity of Nebraska Medical Center - Omaha
Pennsylvania
- Temple University - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2014-01-01 |
| Est. Completion | 2018-03-31 |
| Phase | Phase 2 |
What the finished NCT02006576 record still lists
NCT02006576 is an interventional study that assigns participants to a tested intervention. The registered 118 participants enrollment target is mid-sized for trials with a published cap, below the 3,799-participant average among 25 other Emphysema trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Emphysema appearing as the primary indexed condition, and to 2 interventions - of which 600 mg ibuprofen three times daily for 48 weeks is the first listed.
NCT02006576 lists 5 locations in 5 states (Alabama, California, Colorado).
Frequently Asked Questions
What is clinical trial NCT02006576 about?
NCT02006576 is a clinical study titled "Prostaglandin Inhibition for Emphysema". The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in improvement in measures of lung repair function.
What is the current status of trial NCT02006576?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 118 participants. The study started on 2014-01-01. Estimated completion is 2018-03-31.
What conditions does trial NCT02006576 study?
This clinical trial studies the following conditions: Emphysema.
What interventions are being tested in trial NCT02006576?
The interventions under investigation include: 600 mg ibuprofen three times daily for 48 weeks (DRUG), Placebo three times daily (OTHER).
Who is sponsoring clinical trial NCT02006576?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02006576 being conducted?
This trial has 5 study locations across Alabama, California, Colorado, Nebraska, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Emphysema
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02006576's enrollment target sits among peer trials
118 15th of 25 higher than 11 of 25 other Emphysema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Emphysema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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