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ClinicalTrials.gov 53 recruiting now official registry

Diffuse Large B Cell Lymphoma clinical trials

53 of 115 indexed Diffuse Large B Cell Lymphoma trials are currently recruiting.

115 US clinical trials · 53 currently recruiting

Diffuse Large B Cell Lymphoma is the subject of 115 registered US clinical trials on ClinicalTrials.gov, 53 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 88 in Phase 1-2 (earlier-stage). The most active sponsor is Genmab, running 6 of these trials.

The research picture

Diffuse Large B Cell Lymphoma has 115 registered US clinical trials, 53 of them open to new participants right now, about 46% of the total.

53
recruiting participants now
46%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
6
top sponsor: Genmab
Phase 158Phase 230Phase 311

Active & Recent Trials

115 total, page 1 of 3

RECRUITING 7,000 participants

A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology

OWKIN

NCT06625203

RECRUITING Phase 3 1,046 participants

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Merck Sharp & Dohme

NCT06717347

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING 500 participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Medical College of Wisconsin

NCT03375619

RECRUITING Phase 2 396 participants

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

SWOG Cancer Research Network

NCT05633615

RECRUITING Phase 3 360 participants

A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Genmab

NCT06508658

RECRUITING Phase 1 317 participants

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

AstraZeneca

NCT04594642

RECRUITING 300 participants

Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy

Adaptive Biotechnologies

NCT05255354

RECRUITING Phase 2 290 participants

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

Merck Sharp & Dohme

NCT05139017

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 2 244 participants

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Karyopharm Therapeutics

NCT02227251

RECRUITING 200 participants

Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma

Emory University

NCT03501576

RECRUITING Phase 1 168 participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

OncoNano Medicine

NCT06022029

RECRUITING Phase 1 155 participants

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma

National Cancer Institute (NCI)

NCT03223610

RECRUITING Phase 1 154 participants

A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)

AbbVie

NCT05512390

RECRUITING Phase 1 150 participants

Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets

AbbVie

NCT05618028

RECRUITING Phase 1 140 participants

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

Iksuda Therapeutics

NCT05365659

RECRUITING Phase 2 132 participants

Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

National Cancer Institute (NCI)

NCT04002947

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING 100 participants

realMIND: Observational Study on Safety and Effectiveness of Tafasitamab in Combination With Lenalidomide in Patients With Relapsed or Refractory DLBCL

Incyte Corporation

NCT04981795

RECRUITING Phase 1 90 participants

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Merck Sharp & Dohme

NCT06395103

RECRUITING Phase 2 80 participants

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

AstraZeneca

NCT05952024

RECRUITING Phase 1 60 participants

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Newave Pharmaceutical

NCT04775745

RECRUITING Phase 1 56 participants

A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)

ADC Therapeutics S.A.

NCT05660395

RECRUITING Phase 1 55 participants

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With Polatuzumab (ViPOR-P) in Relapsed/Refractory B-cell Lymphoma

National Cancer Institute (NCI)

NCT04739813

RECRUITING Phase 2 50 participants

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT06736613

RECRUITING 45 participants

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

OHSU Knight Cancer Institute

NCT06784167

RECRUITING NA 40 participants

ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL

Hua-Jay J Cherng, MD

NCT06693830

RECRUITING Phase 1 38 participants

Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma

Weill Medical College of Cornell University

NCT05618366

RECRUITING Phase 2 36 participants

CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant

Washington University School of Medicine

NCT06687772

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 1 35 participants

Tafasitamab, Retifanlimab, and Rituximab in Combination With Standard Therapy for the Treatment of Diffuse Large B-cell Lymphoma

University of Washington

NCT05455697

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 32 participants

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Roswell Park Cancer Institute

NCT06863402

RECRUITING Phase 1 30 participants

Study of IOMAB-ACT Followed by CAR-T Cell Therapy for Patients Relapsed or Refractory (Diffuse Large B-cell Lymphoma

University of Texas Southwestern Medical Center

NCT06768905

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 1 30 participants

Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma

OHSU Knight Cancer Institute

NCT06249191

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 2 27 participants

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05757219

RECRUITING Phase 2 25 participants

Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL

New York Medical College

NCT02393157

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 1 24 participants

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

Jonsson Comprehensive Cancer Center

NCT05256641

RECRUITING Phase 2 21 participants

Zanubrutinib in Patients With DLBCL and MYD88 or NOTCH1 Mutation or CD5+

Virginia Commonwealth University

NCT06846463

RECRUITING Phase 1 20 participants

Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies

Joshua Sasine, MD, PhD

NCT05887167

RECRUITING Phase 1 15 participants

A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

Weill Medical College of Cornell University

NCT05934838

RECRUITING Phase 1 15 participants

Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

Washington University School of Medicine

NCT05412290

RECRUITING Phase 1 15 participants

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT05432635

RECRUITING Phase 1 12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Medical College of Wisconsin

NCT05990465

RECRUITING Early Phase 1 12 participants

Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT04512716

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Phase Distribution

PhaseTrial count
Phase 1 58
Phase 2 30
Phase 3 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diffuse Large B Cell Lymphoma Trial Landscape

115 indexed Diffuse Large B Cell Lymphoma studies · 53 recruiting (46%).

Phase mix: 11 late (III/IV) vs 88 early (I/II).

Top sponsor: Genmab (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diffuse Large B Cell Lymphoma?

PlainTrial tracks 115 US clinical trials for Diffuse Large B Cell Lymphoma, of which 53 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diffuse Large B Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.