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NCT06717347 · ClinicalTrials.gov registry record · Phase 3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
A Phase 3 study of Diffuse Large B Cell Lymphoma, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 1,046
- Enrollment target
- 20
- Study locations
NCT06717347: Recruiting Phase 3 study of Diffuse Large B Cell Lymphoma, sponsored by Merck Sharp & Dohme.
NCT06717347 is a Phase 3 study of Diffuse Large B Cell Lymphoma that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 1,046 participants, above the 209-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (400% higher). The trial reports 20 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06717347, a Phase 3 study of Diffuse Large B Cell Lymphoma, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,046 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.
Primary Outcome
PFS is defined as the time from randomization to the first documented disease progression per Lugano response criteria by blinded independent central review (BICR) or death due to any cause, whichever occurs first.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Doxorubicin
- BIOLOGICAL Rituximab
- BIOLOGICAL Zilovertamab vedotin
- BIOLOGICAL Rituximab Biosimilar
Study Locations (20)
California
- Providence Medical Foundation-Oncology ( Site 0168) - Fullerton
- Cancer Blood and Specialty Clinic ( Site 0109) - Los Alamitos
- Cedars-Sinai Medical Center ( Site 0115) - Los Angeles
- Pacific Hematology Oncology Associates ( Site 0131) - San Francisco
Florida
- Clermont Oncology Center ( Site 0182) - Clermont
- Bioresearch Partner ( Site 0157) - Hialeah
- Orlando Health Cancer Institute ( Site 0169) - Ocoee
- Mid Florida Hematology and Oncology Center ( Site 0172) - Orange City
Arizona
- Banner MD Anderson Cancer Center ( Site 0165) - Gilbert
- Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0167) - Phoenix
- The University of Arizona Cancer Center - North Campus ( Site 0124) - Tucson
Kentucky
- University of Kentucky ( Site 0106) - Lexington
- Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0163) - Louisville
Missouri
- Circuit Clinical - SSM Health Cancer Care DePaul ( Site 0166) - Bridgeton
- Truman Medical Center ( Site 0122) - Kansas City
Colorado
- Lutheran Hospital - Cancer Centers of Colorado ( Site 0180) - Golden
Illinois
- Cancer Care Specialists of Illinois ( Site 0152) - O'Fallon
Indiana
- Fort Wayne Medical Oncology and Hematology ( Site 0149) - Fort Wayne
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,046 participants |
| Start Date | 2025-01-27 |
| Est. Completion | 2032-03-29 |
| Phase | Phase 3 |
What NCT06717347 shows while recruiting
NCT06717347 is an interventional study that assigns participants to a tested intervention. Its 1,046 participants enrollment target places it among the larger protocols in the corpus, above the 209-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (400% higher).
The record links to 1 condition, with Diffuse Large B Cell Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT06717347 names 20 study sites across 10 states, led by California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT06717347 about?
NCT06717347 is a clinical study titled "A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)". The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.
What is the current status of trial NCT06717347?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,046 participants. The study started on 2025-01-27. Estimated completion is 2032-03-29.
What conditions does trial NCT06717347 study?
This clinical trial studies the following conditions: Diffuse Large B Cell Lymphoma.
What interventions are being tested in trial NCT06717347?
The interventions under investigation include: Cyclophosphamide (DRUG), Doxorubicin (DRUG), Rituximab (BIOLOGICAL), Zilovertamab vedotin (BIOLOGICAL), Rituximab Biosimilar (BIOLOGICAL).
Who is sponsoring clinical trial NCT06717347?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06717347 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diffuse Large B Cell Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06717347's enrollment target sits among peer trials
1,046 2nd of 114 the highest of 114 other Diffuse Large B Cell Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diffuse Large B Cell Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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