Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT04594642 · ClinicalTrials.gov registry record · Phase 1

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

A Phase 1 study of Diffuse Large B Cell Lymphoma and Follicular Lymphoma, sponsored by AstraZeneca.

Recruiting
Registry status
Phase 1
Development phase
317
Enrollment target
20
Study locations

NCT04594642 is a Phase 1 study of Diffuse Large B Cell Lymphoma and Follicular Lymphoma that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 317 participants, above the 216-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (47% higher). The trial reports 20 study locations across 10 states.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT04594642, a Phase 1 study of Diffuse Large B Cell Lymphoma and Follicular Lymphoma, is actively recruiting participants, sponsored by AstraZeneca.

RECRUITING
Registry status
Phase 1
Development phase
317 participants
Enrollment target
20
Study locations

Study Summary

This phase 1 study will investigate the safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity of AZD0486, a CD19 x CD3 T-cell engaging bispecific antibody, in subjects with B-cell non-Hodgkin lymphoma (B-NHL).

Conditions Studied

Diffuse Large B Cell Lymphoma Follicular Lymphoma High Grade B-Cell Lymphoma B-Cell Non-Hodgkin Lymphoma

Interventions

  • DRUG AZD0486 IV

Study Locations (20)

Other

  • Research Site - Bedford Park
  • Research Site - Heidelberg
  • Research Site - Hobart
  • Research Site - Melbourne
  • Research Site - Chūōku
  • Research Site - Kōtoku
  • Research Site - Nagoya
  • Research Site - Yamagata
  • Research Site - Seoul
  • Research Site - Seoul

Texas

  • Research Site - Austin
  • Research Site - Houston

Florida

  • Research Site - Tampa

Kentucky

  • Research Site - Louisville

New Jersey

  • Research Site - New Brunswick

North Carolina

  • Research Site - Charlotte

Ohio

  • Research Site - Columbus

Oregon

  • Research Site - Portland

Trial Details

FieldValue
Enrollment Target 317 participants
Start Date 2021-03-02
Est. Completion 2028-04-19
Phase Phase 1

Sponsor

AstraZeneca

1,285 total trials

Interested in This Trial?

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04594642

The ClinicalTrials.gov registry entry for NCT04594642 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 317 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 216-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (47% higher). The listed sponsor is AstraZeneca, which has 1,285 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Diffuse Large B Cell Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which AZD0486 IV is the first listed.

NCT04594642 reports 20 study locations spanning 10 distinct geographic areas - top geographies include Other, Texas, Florida.

Frequently Asked Questions

What is clinical trial NCT04594642 about?

NCT04594642 is a clinical study titled "A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma". This phase 1 study will investigate the safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity of AZD0486, a CD19 x CD3 T-cell engaging bispecific antibody, in subjects with B-cell non-Hodgkin lymphoma (B-NHL).

What is the current status of trial NCT04594642?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 317 participants. The study started on 2021-03-02. Estimated completion is 2028-04-19.

What conditions does trial NCT04594642 study?

This clinical trial studies the following conditions: Diffuse Large B Cell Lymphoma, Follicular Lymphoma, High Grade B-Cell Lymphoma, B-Cell Non-Hodgkin Lymphoma.

What interventions are being tested in trial NCT04594642?

The interventions under investigation include: AZD0486 IV (DRUG).

Who is sponsoring clinical trial NCT04594642?

This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04594642 being conducted?

This trial has 20 study locations across Florida, Kentucky, New Jersey, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Diffuse Large B Cell Lymphoma

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Explore more on PlainTrial

Diffuse Large B Cell Lymphoma

All registered trials for this condition

Follicular Lymphoma

All registered trials for this condition

Florida

All trials with a study site in Florida

Recruiting now

Find trials open to new participants near you

Rankings

Top sponsors, conditions, and phases

Read our methodology - how this data is sourced, computed, and verified.

Related

Browse all → | Rankings →
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.