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NCT05255354 · ClinicalTrials.gov registry record
Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy
A clinical trial of Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma, sponsored by Adaptive Biotechnologies.
- Recruiting
- Registry status
- 300
- Enrollment target
- 1
- Study location
NCT05255354: Recruiting study of Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma, sponsored by Adaptive Biotechnologies.
NCT05255354 is a study of Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma that is actively recruiting participants, run by Adaptive Biotechnologies. The registered enrollment target is 300 participants, above the 216-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (39% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05255354, a study of Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma, is actively recruiting participants, sponsored by Adaptive Biotechnologies.
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
In this study, invesigators propose to analyze 150 DLBCL patients, 50 MCL patients, and 100 FL patients to determine the clinical utility of ctDNA- as well as circulating tumor cell (CTC)-based MRD assessment in CAR therapy patients. The project detailed in this protocol will utilize the clonoSEQ platform as specific quantification of residual DLBCL/FL/MCL and correlate its results with radiologic assessment of disease and clinical outcomes. Invesitgators predict there will be a strong correlation between ctDNA and PET/CT and dynamic changes in ctDNA will precede radiologic evidence of disease recurrence in patients following CAR therapy.
Primary Outcome
Ability of ctDNA MRD assessment to predict progression-free survival (PFS) at 6 months following CAR infusion in DLBCL, FL and MCL patients.
Conditions Studied
Interventions
- DEVICE ClonoSEQ
Study Locations (1)
California
- Stanford Cancer Center - Palo Alto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2022-06-01 |
| Est. Completion | 2026-12-31 |
What NCT05255354 shows while recruiting
NCT05255354 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, above the 216-participant average among 114 other Diffuse Large B Cell Lymphoma trials with a reported enrollment target (39% higher).
The record links to 3 conditions, with Diffuse Large B Cell Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which ClonoSEQ is the first listed.
NCT05255354 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05255354 about?
NCT05255354 is a clinical study titled "Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy". In this study, invesigators propose to analyze 150 DLBCL patients, 50 MCL patients, and 100 FL patients to determine the clinical utility of ctDNA- as well as circulating tumor cell (CTC)-based MRD assessment in CAR therapy patients. The project detailed in this protocol will utilize the clonoSEQ pl...
What is the current status of trial NCT05255354?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2022-06-01. Estimated completion is 2026-12-31.
What conditions does trial NCT05255354 study?
This clinical trial studies the following conditions: Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma.
What interventions are being tested in trial NCT05255354?
The interventions under investigation include: ClonoSEQ (DEVICE).
Who is sponsoring clinical trial NCT05255354?
This trial is sponsored by Adaptive Biotechnologies, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05255354 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diffuse Large B Cell Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05255354's enrollment target sits among peer trials
300 19th of 114 higher than 96 of 114 other Diffuse Large B Cell Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diffuse Large B Cell Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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