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RECRUITING Phase 2

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

NCT05952024 · View on ClinicalTrials.gov ↗

Study Summary

The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise unsuitable for standard front line chemoimmunotherapy treatments.

Interventions

  • BIOLOGICAL Rituximab
  • DRUG Acalabrutinib

Study Locations (20)

Brasilia

  • Research Site — Distrito Federal
  • Research Site — Distrito Federal
  • Research Site — Distrito Federal

California

  • Research Site — La Jolla
  • Research Site — Orange

Maryland

  • Research Site — Baltimore
  • Research Site — Rockville

Washington

  • Research Site — Olympia
  • Research Site — Tacoma

Florida

  • Research Site — Jacksonville

Iowa

  • Research Site — Waukee

Michigan

  • Research Site — Detroit

Texas

  • Research Site — Lubbock

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-07-16
Est. Completion 2027-08-24
Phase Phase 2

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05952024

The ClinicalTrials.gov registry entry for NCT05952024 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Diffuse Large B-Cell Lymphoma appearing as the primary indexed condition, and to 2 interventions — of which Rituximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05952024 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Brasilia, California, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05952024 about?

NCT05952024 is a clinical study titled "Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL". The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise unsuitable for standard front line chemoimmunotherapy treatments.

What is the current status of trial NCT05952024?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2024-07-16. Estimated completion is 2027-08-24.

What conditions does trial NCT05952024 study?

This clinical trial studies the following conditions: Diffuse Large B-Cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05952024?

The interventions under investigation include: Rituximab (BIOLOGICAL), Acalabrutinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05952024?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05952024 being conducted?

This trial has 20 study locations across California, Florida, Iowa, Maryland, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial