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RECRUITING Phase 2

Emapalumab Prevention of CAR-T Cell Associated Toxicities

NCT06550141 · View on ClinicalTrials.gov ↗

Study Summary

This research study involves assessing the impact of emapalumab as preventative management of CAR-T related cytokine release syndrome in participants with Non-Hodgkin's lymphoma (NHL). The research study involves the following study interventions: * Fludarabine and cyclophosphamide (Lymphodepleting Chemotherapy) * Axicabtagene Ciloleucel * Emapalumab

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine Phosphate
  • DRUG Axicabtagene Ciloleucel
  • DRUG Emapalumab

Study Locations (2)

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

Trial Details

FieldValue
Enrollment Target 28 participants
Start Date 2024-09-18
Est. Completion 2027-08-01
Phase Phase 2

Sponsor

Marcela V. Maus, M.D.,Ph.D.

92 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06550141

The ClinicalTrials.gov registry entry for NCT06550141 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 28 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Marcela V. Maus, M.D.,Ph.D., which has 92 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Follicular Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06550141 reports 2 study locations spanning 1 distinct geographic area — top geographies include Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06550141 about?

NCT06550141 is a clinical study titled "Emapalumab Prevention of CAR-T Cell Associated Toxicities". This research study involves assessing the impact of emapalumab as preventative management of CAR-T related cytokine release syndrome in participants with Non-Hodgkin's lymphoma (NHL). The research study involves the following study interventions: * Fludarabine and cyclophosphamide (Lymphodepletin...

What is the current status of trial NCT06550141?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 28 participants. The study started on 2024-09-18. Estimated completion is 2027-08-01.

What conditions does trial NCT06550141 study?

This clinical trial studies the following conditions: Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Large B-cell Lymphoma, Refractory Non-Hodgkin Lymphoma, High-grade B-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06550141?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine Phosphate (DRUG), Axicabtagene Ciloleucel (DRUG), Emapalumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06550141?

This trial is sponsored by Marcela V. Maus, M.D.,Ph.D., which has 92 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06550141 being conducted?

This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial