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ClinicalTrials.gov 86 recruiting now later-stage tilt #19 of 28,707 conditions

Diabetes: later-stage trial registry

86 of 342 indexed Diabetes trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #19 of 28,707 conditions by registered trial count.

342 US clinical trials · 86 currently recruiting · #19 of 28,707 conditions by registered trial count

Diabetes: 342 US clinical trials tracked, 86 recruiting.

Diabetes is the subject of 342 registered US clinical trials on ClinicalTrials.gov, 86 of them currently open to new participants. 55 are in Phase 3-4 (later-stage) and 36 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 41 of these trials.

Enrollment posture brief

Registry condition diabetes

OPEN 86 | RECR 25% | LATE 55 | EARLY 36 | RANK #19 | SPON 41

Nearest open-share peer: Low Back Pain (25% recruiting · 123 trials)

Ovarian Cancer43.5%Type 2 Diabetes36.6%Lymphoma26.7%Diabetes (this)25%Diabetes Mellitus, Type 217.9%
Open-enrollment share among volume-matched conditions near Diabetes

Diabetes lists 86 open slots (25% of 342 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Diabetes on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Diabetes is recruiting below its size-band peers.

    86 of 342 indexed trials (25.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Diabetes trials is spread across many organizations.

    Novo Nordisk A/S accounts for 41 of 342 trials (12%). 161 distinct sponsors appear on at least one study for this condition label.

  3. Typical Diabetes enrolment sits around 150 participants.

    Median target enrolment is 150 among the 339 trials that report a genuine target (sentinel values excluded). 144 of those (42.5%) plan for fewer than 100 participants.

  4. Diabetes research is mostly interventional.

    263 interventional and 79 observational studies make up this index (76.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 123Phase 213Phase 337Phase 418

Open and recent trials

342 total, page 3 of 7

ACTIVE NOT RECRUITING Phase 1 40 participants

Insulin Balanced Infusion System

Admetsys Corporation

NCT01291719

ACTIVE NOT RECRUITING 35 participants

REsearching Covid-19 Outcomes in Diabetes (RECODE)

AdventHealth Translational Research Institute

NCT04805970

ACTIVE NOT RECRUITING NA 35 participants

Monitoring Your Exercise-related Metrics Over Time Via Wearable Electronic Devices

M.D. Anderson Cancer Center

NCT05124405

ACTIVE NOT RECRUITING Phase 2 29 participants

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262806

ACTIVE NOT RECRUITING NA 25 participants

Patient Specific 3D Printed Diabetic Insoles to Reduce Plantar Pressure

VA Office of Research and Development

NCT05301478

ACTIVE NOT RECRUITING 25 participants

CharacterIzation of Adult Onset Autoimmune Diabetes

AdventHealth Translational Research Institute

NCT03971955

ACTIVE NOT RECRUITING NA 25 participants

I Can Do This! Managing My Diabetes

Emory University

NCT06695533

ACTIVE NOT RECRUITING Phase 3 24 participants

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262832

COMPLETED 168,690 participants

Replication of the LEADER Diabetes Trial in Healthcare Claims

Brigham and Women's Hospital

NCT03936049

COMPLETED 103,752 participants

Replication of the EMPAREG Diabetes Trial in Healthcare Claims

Brigham and Women's Hospital

NCT04215536

COMPLETED 101,830 participants

Replication of the CARMELINA Diabetes Trial in Healthcare Claims

Brigham and Women's Hospital

NCT03936036

COMPLETED NA 47,088 participants

Effect of Reminders on Adherence

University of Pennsylvania

NCT02411006

COMPLETED 39,481 participants

Improving Service Delivery Through Access Points

US Department of Veterans Affairs

NCT00012623

COMPLETED open-ended (no fixed target)

Estimation of Malignancy Rates Within Humedica Patient Populations Sampled to be Representative of Liraglutide Initiators and LEADER™ Trial Participants

Novo Nordisk A/S

NCT02608853

COMPLETED 9,000 participants

Environmental Polymorphisms Registry Health and Exposures Survey

National Institute of Environmental Health Sciences (NIEHS)

NCT01688986

COMPLETED Phase 3 7,637 participants

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Novo Nordisk A/S

NCT01959529

COMPLETED Phase 1 7,192 participants

Cooking for Health Optimization With Patients

Tulane University

NCT03443635

COMPLETED Phase 4 4,877 participants

INITIATE Plus (INITiation of Insulin to Reach A1c TargEt) Study

Novo Nordisk A/S

NCT00101751

COMPLETED NA 4,622 participants

Adherence and Intensification of Medications (AIM) Implementation Study

US Department of Veterans Affairs

NCT00495794

COMPLETED 4,219 participants

Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era

VA Office of Research and Development

NCT00958061

COMPLETED 3,184 participants

Diabetes in the Perioperative Period

Emory University

NCT00738114

COMPLETED Phase 3 1,663 participants

Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes

Novo Nordisk A/S

NCT01336023

COMPLETED Phase 3 1,609 participants

A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated With Basal Insulin With or Without Oral Antidiabetic Drugs

Novo Nordisk A/S

NCT03078478

COMPLETED NA 1,580 participants

Addressing Diffusion of Responsibility and Prescribing Burden to Improve Use of Diabetes Medications

Brigham and Women's Hospital

NCT05463705

COMPLETED Phase 3 1,398 participants

The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes

Novo Nordisk A/S

NCT01836523

COMPLETED Phase 1 1,298 participants

Family Management of Childhood Diabetes Study

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00340938

COMPLETED NA 1,283 participants

"Working for You" Workplace Obesity Intervention

Washington University School of Medicine

NCT02934113

COMPLETED 1,248 participants

Insulin Treatment Variation in Southwestern Diabetics

VA Office of Research and Development

NCT00148304

COMPLETED Phase 3 1,201 participants

Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes.

Novo Nordisk A/S

NCT02648204

COMPLETED Phase 3 1,151 participants

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

University of Virginia

NCT01369069

COMPLETED NA 1,114 participants

Study of a Holistic Health Program for United Methodist Clergy

Duke Clergy Health Initiative

NCT01564719

COMPLETED Phase 3 1,108 participants

Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT02500706

COMPLETED Phase 3 1,089 participants

Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes

Novo Nordisk A/S

NCT02128932

COMPLETED Phase 3 1,006 participants

Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes

Novo Nordisk A/S

NCT00972283

COMPLETED NA 1,000 participants

Improving Self Management Skills of Older Adults With Diabetes

Stanford University

NCT01943357

COMPLETED Phase 3 928 participants

A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time

Eli Lilly and Company

NCT05362058

COMPLETED Phase 3 881 participants

Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 Diabetes

Novo Nordisk A/S

NCT01819129

COMPLETED Phase 3 822 participants

Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus

Novo Nordisk A/S

NCT02863328

COMPLETED Phase 3 813 participants

Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes

Novo Nordisk A/S

NCT01885208

COMPLETED 719 participants

CARDIA Brain MRI Substudy

National Institute on Aging (NIA)

NCT01273311

COMPLETED Phase 3 711 participants

Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus

Novo Nordisk A/S

NCT02863419

COMPLETED Phase 3 692 participants

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Eli Lilly and Company

NCT05463744

COMPLETED Phase 3 665 participants

The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes Mellitus

Novo Nordisk A/S

NCT00700817

COMPLETED NA 647 participants

The CREATE Wellness Study

Kaiser Permanente

NCT02302612

COMPLETED Phase 2 632 participants

Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes

Novo Nordisk A/S

NCT01923181

COMPLETED Phase 3 629 participants

Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00982228

COMPLETED Phase 4 611 participants

Impact of Dietary Intervention on Weight Change in Subjects With Type 2 Diabetes

Novo Nordisk A/S

NCT01232491

COMPLETED NA 556 participants

Coalition for a Healthier Community-Utah Women and Girls - Phase II (UWAG-II)

University of Utah

NCT02470156

COMPLETED Phase 3 548 participants

Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00978627

COMPLETED Phase 4 513 participants

NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes

Novo Nordisk A/S

NCT00095446

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 13
Phase 3 37
Phase 4 18

Named interventions

Most-linked intervention names on Diabetes records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

insulin degludec Drug
11 trials
Placebo Drug
10 trials
insulin glargine Drug
9 trials
insulin aspart Drug
9 trials
semaglutide Drug
7 trials
liraglutide Drug
6 trials
placebo Drug
6 trials
insulin detemir Drug
4 trials

US sites by state

Facility locations filed on Diabetes trials. A trial with sites in several states counts in each.

California 82 trials
Florida 59 trials
Maryland 39 trials
Georgia 38 trials
Massachusetts 35 trials
Texas 33 trials
New York 31 trials
Colorado 31 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Diabetes page

342 registered trials, 86 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Diabetes condition card totals 342 registered trials; most-linked intervention insulin degludec; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.