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ClinicalTrials.gov 39 recruiting now official registry

Diabetes Mellitus, Type 1 clinical trials

39 of 119 indexed Diabetes Mellitus, Type 1 trials are currently recruiting.

119 US clinical trials · 39 currently recruiting

Diabetes Mellitus, Type 1 is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 31 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 11 of these trials.

The research picture

Diabetes Mellitus, Type 1 has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.

39
recruiting participants now
33%
of trials open to enrollment
31
in Phase 3–4 (later-stage)
11
top sponsor: Novo Nordisk A/S
Phase 113Phase 214Phase 323Phase 48

Active & Recent Trials

119 total, page 3 of 3

COMPLETED NA 29 participants

A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect

Yale University

NCT02970656

COMPLETED Phase 2 29 participants

A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus and to Compare One of Those Formulations (30Units) With an Injection of Insulin Lispro

Mannkind Corporation

NCT00662857

COMPLETED NA 27 participants

A Continuous Glucose Monitor Based Insulin Bolus Calculator

Welldoc

NCT05229445

COMPLETED Phase 4 25 participants

Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.

Sansum Diabetes Research Institute

NCT03668808

COMPLETED 22 participants

Study of Calcium Metabolism in Teenage Girls With Type 1 Diabetes

University of Rochester

NCT03156179

COMPLETED NA 21 participants

Assessment of an Automatic Closed-loop Insulin Delivery System

Stanford University

NCT02366767

COMPLETED Phase 4 20 participants

Afrezza® Dosing Optimization Study

Mannkind Corporation

NCT04849845

COMPLETED Phase 2 20 participants

To Examine the Lung When People With Diabetes Take an Inhaled Form of Insulin, Compared to Subcutaneous Insulin.

Pfizer

NCT00143104

COMPLETED Phase 2 18 participants

Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D

Xeris Pharmaceuticals

NCT04074317

COMPLETED NA 14 participants

A Clinical Study to Investigate and Compare the Impact of High Protein Pasta, Lower Protein Pasta and White Rice on Blood Sugar Control in People With Type 1 Diabetes Mellitus (T1DM)

Sansum Diabetes Research Institute

NCT03362151

COMPLETED NA 12 participants

Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes

Yale University

NCT00592072

COMPLETED Phase 2 10 participants

A Study to Assess the Safety of Single Doses of GSK189075 in Subjects With Type 1 Diabetes Mellitus

GlaxoSmithKline

NCT00575159

COMPLETED Phase 1 10 participants

Islet Transplantation for Patients With Type 1 Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00073281

COMPLETED NA 10 participants

Acceptability of Virtual Educational Intervention for Adolescents and Young Adults With Type 1 Diabetes Mellitus

University Hospitals Cleveland Medical Center

NCT04878419

COMPLETED NA 9 participants

Phase 2 Study of Adaptive Insulin Meal Supervisor (AIMS) in Adults With Type 1 Diabetes Mellitus

University of Virginia

NCT01839370

COMPLETED NA 9 participants

Integrated Behavioral Healthcare for Youth With Type 1 Diabetes

University of Miami

NCT05915975

COMPLETED Phase 4 8 participants

Sitagliptin Dose Determination Study

Albert Einstein College of Medicine

NCT01530178

COMPLETED Phase 2 7 participants

Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation

Rodolfo Alejandro

NCT00315588

COMPLETED NA 7 participants

Pharmacokinetics (PK)/ Pharmacodynamics (PD) of an Extended Wear Infusion Set for Continuous Subcutaneous Insulin Infusion (CSII) in Type 1 Diabetes Mellitus (T1DM) Patients ("PEXIS")

Capillary Biomedical

NCT04398030

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 14
Phase 3 23
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 1 Trial Landscape

119 indexed Diabetes Mellitus, Type 1 studies · 39 recruiting (33%).

Phase mix: 31 late (III/IV) vs 27 early (I/II).

Top sponsor: Novo Nordisk A/S (11 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 1?

PlainTrial tracks 119 US clinical trials for Diabetes Mellitus, Type 1, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 1?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.