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NCT00943787 · ClinicalTrials.gov registry record · NA
Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus
A NA study of Diabetes Mellitus, Type 1, sponsored by University of Virginia.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
- 1
- Study location
NCT00943787: Completed NA study of Diabetes Mellitus, Type 1, sponsored by University of Virginia.
NCT00943787 is a NA study of Diabetes Mellitus, Type 1 that has completed, run by University of Virginia. The registered enrollment target is 41 participants, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00943787, a NA study of Diabetes Mellitus, Type 1, has completed, sponsored by University of Virginia.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
- 1
- Study location
Study Summary
The researchers plan to test the following hypothesis: A good level of glucose control in Type 1 Diabetes Mellitus (T1DM) is dependent on two levels of feedback from the body: 1. the transport of insulin through small blood vessels: suggesting that hypoglycemia leads to increased insulin sensitivity which then causes recurrent hypoglycemia; 2. the endocrine level, defined as insulin-glucose interaction and hormonal counter-regulation. The researchers plan to investigate the relationships between hypoglycemia, insulin transport, and counter-regulation. This study will ultimately lead to a better understanding of risk for recurrent hypoglycemia.
Primary Outcome
Mean maximum epinephrine response during induced hypoglycemia is the average of subjects' maximum concentration of all epinephrine measurements taken at plasma glucose level lower than 70mg/dL. Low blood glucose index (LBGI) is a metric to calculate the risk for hypoglycemia based on frequency and extent of past events based on SMBG readings. In studies, the LBGI typically accounted for 40-55% of the variance of future significant hypoglycemia in the subsequent 3-6 months. The LBGI has establis
Conditions Studied
Interventions
- PROCEDURE Hyperinsulinemic, euglycemic and hypoglycemic clamp
Study Locations (1)
Virginia
- University of Virginia Health System - Behavioral Medicine Center - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2006-01 |
| Est. Completion | 2009-05 |
| Phase | NA |
What the finished NCT00943787 record still lists
NCT00943787 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Diabetes Mellitus, Type 1 appearing as the primary indexed condition, and to 1 intervention - of which Hyperinsulinemic, euglycemic and hypoglycemic clamp is the first listed.
NCT00943787 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT00943787 about?
NCT00943787 is a clinical study titled "Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus". The researchers plan to test the following hypothesis: A good level of glucose control in Type 1 Diabetes Mellitus (T1DM) is dependent on two levels of feedback from the body: 1. the transport of insulin through small blood vessels: suggesting that hypoglycemia leads to increased insulin sensitivi...
What is the current status of trial NCT00943787?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2006-01. Estimated completion is 2009-05.
What conditions does trial NCT00943787 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 1.
What interventions are being tested in trial NCT00943787?
The interventions under investigation include: Hyperinsulinemic, euglycemic and hypoglycemic clamp (PROCEDURE).
Who is sponsoring clinical trial NCT00943787?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00943787 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetes Mellitus, Type 1
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00943787's enrollment target sits among peer trials
41 81st of 118 higher than 37 of 118 other Diabetes Mellitus, Type 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes Mellitus, Type 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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