Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 13 of 14
e-Mindfulness for Depression in Older Adults
Washington University School of Medicine
NCT03922217
Pilot Trial of Phototherapy for Acute Depression in Hospitalized Cystic Fibrosis Patients
Nationwide Children's Hospital
NCT01822197
Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
University of North Carolina, Chapel Hill
NCT05205772
Improving Care of Patients With Heart Failure
University of California, San Francisco
NCT01461681
Mindfulness for Breast Cancer
NYU Langone Health
NCT02647216
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
University of Pittsburgh
NCT02384590
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
Joshua Woolley
NCT02950467
Frontline Clinician Psilocybin Study
University of Washington
NCT05163496
Beating the Blues for Your Heart
Indiana University
NCT01605552
Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
University of California, San Diego
NCT02330627
SAM-e for the Treatment of Depression in Patients With Parkinson's Disease
NYU Langone Health
NCT00070941
Acceleration and Relapse Prevention With Triiodothyronine (T3) as an Adjunct to Electroconvulsive Therapy (ECT)
Mayo Clinic
NCT01299337
Duloxetine for Menopausal Depression
Massachusetts General Hospital
NCT01117857
A Study of Sertraline to Prevent PTSD
Massachusetts General Hospital
NCT00182078
UCSF TARA Study: Training for Awareness, Resilience and Action
University of California, San Francisco
NCT02480257
Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder
Stanford University
NCT05525390
Increasing Physical Activity in Persons With Depression
University of Texas Southwestern Medical Center
NCT02781688
A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression
Orexigen Therapeutics
NCT00624858
Financial Incentives to Improve Medication Adherence
Northwell Health
NCT04191876
Study of Naltrexone-Induced Blockade of Antidepressant Effects
Marta Peciña, MD PhD
NCT04322526
Ketamine for Depression: An MRI Study
Massachusetts General Hospital
NCT02544607
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
Boston University
NCT00322309
Concurrent Treatment for Depressed Parents and DepressedAdolescents
Brown University
NCT00951821
Massage To Improve Uterine Artery Blood Flow
Miguel Diego
NCT02203734
Transforming Psychotherapy for Chronically Ill Patients
US Department of Veterans Affairs
NCT00520429
Synchronized Transcranial Magnetic Stimulation for PTSD
Providence VA Medical Center
NCT02981381
A Trial of SAMe for Treatment-Resistant Bipolar Depression
Mclean Hospital
NCT00762268
Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study
University of Minnesota
NCT06149624
Personalized Depression Treatment Supported by Mobile Sensor Analytics
UConn Health
NCT06292221
Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
University of California, Los Angeles
NCT05612685
Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
NYU Langone Health
NCT02106325
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Alliance for Clinical Trials in Oncology
NCT00005850
Designing a Mental Health Model for Latina Women
University of New Mexi
NCT03901430
Nitrous Oxide as Treatment for Major Depression - a Pilot Study
Washington University School of Medicine
NCT02139540
Depression-Diabetes Mechanisms: Urban African Americans
Emory University
NCT00209170
Trigeminal Nerve Stimulation for Depression: Dose Finding
University of California, Los Angeles
NCT01343563
Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction
Massachusetts General Hospital
NCT00181961
Quetiapine in Melancholic Depression
University of Cincinnati
NCT01200901
VOICES Socials for Older Veterans With Depression
VA Office of Research and Development
NCT06145334
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
University of Washington
NCT00524420
Health At Every Size and Acceptance and Commitment Therapy vs. Behavioral Weight Loss for Obesity and Depression in Women
Dartmouth-Hitchcock Medical Center
NCT02501239
VA Home-Based Emotional Learning With Practical Skills
Baylor College of Medicine
NCT01685528
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
University of Pennsylvania
NCT00626340
Adjunctive Transcranial Direct Current Stimulation for Cognition in Major Depression
University of California, Los Angeles
NCT00760097
Parenting Young Children in Pediatrics
University of Oregon
NCT06273228
Depression Decision Aid: Feasibility Pilot
Weill Medical College of Cornell University
NCT02239367
In Vivo Imaging of Therapeutic Electric Current Flow
University of Florida
NCT02453763
Traditional African Healing Ceremony in a U.S. Population
Duke University
NCT01873482
Determining Relationships Among Maternity Stress & Sleep
University of North Carolina, Chapel Hill
NCT02133963
Cognitive Enhancement in Depression (The COG-D Study)
Vanderbilt University Medical Center
NCT05400512
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.