Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 13 of 14
e-Mindfulness for Depression in Older Adults
Washington University School of Medicine
NCT03922217
Pilot Trial of Phototherapy for Acute Depression in Hospitalized Cystic Fibrosis Patients
Nationwide Children's Hospital
NCT01822197
Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
University of North Carolina, Chapel Hill
NCT05205772
Improving Care of Patients With Heart Failure
University of California, San Francisco
NCT01461681
Mindfulness for Breast Cancer
NYU Langone Health
NCT02647216
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
University of Pittsburgh
NCT02384590
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
Joshua Woolley
NCT02950467
Frontline Clinician Psilocybin Study
University of Washington
NCT05163496
Beating the Blues for Your Heart
Indiana University
NCT01605552
Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
University of California, San Diego
NCT02330627
SAM-e for the Treatment of Depression in Patients With Parkinson's Disease
NYU Langone Health
NCT00070941
Acceleration and Relapse Prevention With Triiodothyronine (T3) as an Adjunct to Electroconvulsive Therapy (ECT)
Mayo Clinic
NCT01299337
Duloxetine for Menopausal Depression
Massachusetts General Hospital
NCT01117857
A Study of Sertraline to Prevent PTSD
Massachusetts General Hospital
NCT00182078
UCSF TARA Study: Training for Awareness, Resilience and Action
University of California, San Francisco
NCT02480257
Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder
Stanford University
NCT05525390
Increasing Physical Activity in Persons With Depression
University of Texas Southwestern Medical Center
NCT02781688
A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression
Orexigen Therapeutics
NCT00624858
Financial Incentives to Improve Medication Adherence
Northwell Health
NCT04191876
Study of Naltrexone-Induced Blockade of Antidepressant Effects
Marta Peciña, MD PhD
NCT04322526
Ketamine for Depression: An MRI Study
Massachusetts General Hospital
NCT02544607
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
Boston University
NCT00322309
Concurrent Treatment for Depressed Parents and DepressedAdolescents
Brown University
NCT00951821
Massage To Improve Uterine Artery Blood Flow
Miguel Diego
NCT02203734
Transforming Psychotherapy for Chronically Ill Patients
US Department of Veterans Affairs
NCT00520429
Synchronized Transcranial Magnetic Stimulation for PTSD
Providence VA Medical Center
NCT02981381
A Trial of SAMe for Treatment-Resistant Bipolar Depression
Mclean Hospital
NCT00762268
Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study
University of Minnesota
NCT06149624
Personalized Depression Treatment Supported by Mobile Sensor Analytics
UConn Health
NCT06292221
Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
University of California, Los Angeles
NCT05612685
Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
NYU Langone Health
NCT02106325
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Alliance for Clinical Trials in Oncology
NCT00005850
Designing a Mental Health Model for Latina Women
University of New Mexi
NCT03901430
Nitrous Oxide as Treatment for Major Depression - a Pilot Study
Washington University School of Medicine
NCT02139540
Depression-Diabetes Mechanisms: Urban African Americans
Emory University
NCT00209170
Trigeminal Nerve Stimulation for Depression: Dose Finding
University of California, Los Angeles
NCT01343563
Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction
Massachusetts General Hospital
NCT00181961
Quetiapine in Melancholic Depression
University of Cincinnati
NCT01200901
VOICES Socials for Older Veterans With Depression
VA Office of Research and Development
NCT06145334
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
University of Washington
NCT00524420
Health At Every Size and Acceptance and Commitment Therapy vs. Behavioral Weight Loss for Obesity and Depression in Women
Dartmouth-Hitchcock Medical Center
NCT02501239
VA Home-Based Emotional Learning With Practical Skills
Baylor College of Medicine
NCT01685528
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
University of Pennsylvania
NCT00626340
Adjunctive Transcranial Direct Current Stimulation for Cognition in Major Depression
University of California, Los Angeles
NCT00760097
Parenting Young Children in Pediatrics
University of Oregon
NCT06273228
Depression Decision Aid: Feasibility Pilot
Weill Medical College of Cornell University
NCT02239367
In Vivo Imaging of Therapeutic Electric Current Flow
University of Florida
NCT02453763
Traditional African Healing Ceremony in a U.S. Population
Duke University
NCT01873482
Determining Relationships Among Maternity Stress & Sleep
University of North Carolina, Chapel Hill
NCT02133963
Cognitive Enhancement in Depression (The COG-D Study)
Vanderbilt University Medical Center
NCT05400512
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.