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NCT05205772 · ClinicalTrials.gov registry record · NA
Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
A NA study of Depression and Parkinson Disease, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05205772: Completed NA study of Depression and Parkinson Disease, sponsored by University of North Carolina, Chapel Hill.
NCT05205772 is a NA study of Depression and Parkinson Disease that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 30 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05205772, a NA study of Depression and Parkinson Disease, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized, single-blinded, triple crossover study focused on determining the feasibility of using transcranial magnetic stimulation (TMS) for treatment of Parkinson's disease related autonomic dysfunction and depression. Participants will undergo TMS to three brain regions: medial prefrontal cortex (mPFC) (experimental site), dorsolateral prefrontal cortex (DLPFC) (alternative experimental site), or primary sensory cortex (S1) (control site) in a triple crossover design. Participants will complete symptom questionnaires, neurologic examination and cognitive assessments, and orthostatic vital signs recording before and after each brain stimulation session.
Primary Outcome
Degree of change of frontal midline theta (FMT) power on electroencephalography (EEG) after brain stimulation at each site (medial prefrontal cortex, dorsolateral prefrontal cortex, control site).
Conditions Studied
Interventions
- DEVICE transcranial magnetic stimulation
Study Locations (1)
North Carolina
- University of North Carolina School of Medicine - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-02-01 |
| Est. Completion | 2024-07-30 |
| Phase | NA |
What the finished NCT05205772 record still lists
NCT05205772 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (96% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which transcranial magnetic stimulation is the first listed.
NCT05205772 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05205772 about?
NCT05205772 is a clinical study titled "Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease". This is a randomized, single-blinded, triple crossover study focused on determining the feasibility of using transcranial magnetic stimulation (TMS) for treatment of Parkinson's disease related autonomic dysfunction and depression. Participants will undergo TMS to three brain regions: medial prefron...
What is the current status of trial NCT05205772?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2022-02-01. Estimated completion is 2024-07-30.
What conditions does trial NCT05205772 study?
This clinical trial studies the following conditions: Depression, Parkinson Disease, Autonomic Dysfunction.
What interventions are being tested in trial NCT05205772?
The interventions under investigation include: transcranial magnetic stimulation (DEVICE).
Who is sponsoring clinical trial NCT05205772?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05205772 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05205772's enrollment target sits among peer trials
30 557th of 679 higher than 105 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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