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NCT05400512 · ClinicalTrials.gov registry record · NA
Cognitive Enhancement in Depression (The COG-D Study)
A NA study of Depression and Aging, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 16
- Enrollment target
- 1
- Study location
NCT05400512: Completed NA study of Depression and Aging, sponsored by Vanderbilt University Medical Center.
NCT05400512 is a NA study of Depression and Aging that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 16 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05400512, a NA study of Depression and Aging, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of computerized cognitive training in older adults with recurrent depression (2 or more lifetime episodes; either current or within past 3 years).
Primary Outcome
MRI scans will be performed at baseline and after completion of the intervention. MRI will measure Cognitive Control Network function, operationalized as change in n-back functional MRI response in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), and the posterior parietal cortex (PPC) regions of interest. The n-back functional MRI response is calculated as the activation difference (beta values) between 2-back and 0-back conditions of the n-back over time (post treat
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Training
- DEVICE tDCS (active stimulation)
- DEVICE tDCS (sham stimulation)
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2023-02-08 |
| Est. Completion | 2025-08-18 |
| Phase | NA |
What the finished NCT05400512 record still lists
NCT05400512 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions - of which Cognitive Training is the first listed.
NCT05400512 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT05400512 about?
NCT05400512 is a clinical study titled "Cognitive Enhancement in Depression (The COG-D Study)". This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of computerized cognitive training in older adults with recurrent depression (2 or more lifetime episodes; either current or within past 3 years).
What is the current status of trial NCT05400512?
This trial is currently completed. It is a NA study. The enrollment target is 16 participants. The study started on 2023-02-08. Estimated completion is 2025-08-18.
What conditions does trial NCT05400512 study?
This clinical trial studies the following conditions: Depression, Aging, Cognitive Symptom.
What interventions are being tested in trial NCT05400512?
The interventions under investigation include: Cognitive Training (BEHAVIORAL), tDCS (active stimulation) (DEVICE), tDCS (sham stimulation) (DEVICE).
Who is sponsoring clinical trial NCT05400512?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05400512 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05400512's enrollment target sits among peer trials
16 635th of 679 higher than 40 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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