Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 12 of 14
Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study
Seattle Institute for Biomedical and Clinical Research
NCT00880152
Improving Retention of Hispanics Receiving Antidepressant Therapy
New York State Psychiatric Institute
NCT00057642
S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors
SWOG Cancer Research Network
NCT01453452
Motivational Interviewing to Improve Medication Adherence Among Hispanic Adults With Depression
University of Medicine and Dentistry of New Jersey
NCT00356304
Dose-Response Effect Exercise and Depression
University of Central Florida
NCT06166095
Online Peer Networked Collaborative Learning for Managing Depressive Symptoms
Northwestern University
NCT02841787
Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)
University of Pittsburgh
NCT03982043
Virtual Lifestyle Medicine Comparative Effectiveness Research
Ohio University
NCT03731481
You Are What You Eat: Food As a Risk Factor and a Treatment for Depression
University of Michigan
NCT06242665
Effect of Whole Blueberry Powder Consumption on Depression in a Central Louisiana Population
Louisiana State University, Baton Rouge
NCT04398784
Healing Touch in Treating Fatigue in Women Undergoing Radiation Therapy for Breast Cancer
Vanderbilt-Ingram Cancer Center
NCT00574145
Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults
University of Washington
NCT04966910
Pilot Test of a Cultural Intervention to Enhance Alaska Native Students' Behavioral Health
University of Alaska Anchorage
NCT04561544
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Massachusetts General Hospital
NCT02447744
IPC for University Counseling Centers
Johns Hopkins University
NCT03255954
Effect of Family-Based Prevention on Children of Depressed Parents
Children's Hospital of Philadelphia
NCT00183365
Distance Savvy: Testing Tele-Savvy, a Distance Dementia Family Caregiver Education Program
Emory University
NCT02300584
Dynamic Measures of Neurochemistry in Mood Disorders
Vanderbilt University Medical Center
NCT00178828
Treatment for Depression Among HIV-Infected Youth
University of North Carolina, Chapel Hill
NCT01049789
Treatment of Depressed Adolescents With Physical Illness
University of Pittsburgh
NCT00446238
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Dennis Charney
NCT00749203
EM/PROTECT: Improving Depression in Elder Mistreatment Victims
Weill Medical College of Cornell University
NCT03241225
Effects of Therapist Behavior on the Treatment of Depressed Adolescents
University of Denver
NCT00073359
Ketamine and Nitroprusside for Depression
Icahn School of Medicine at Mount Sinai
NCT03102736
Care Outcomes for Chiropractic Outpatient Veterans
Palmer College of Chiropractic
NCT03254719
Study of Duloxetine vs Placebo in Treatment of Binge Eating Disorder With Depression
University of Cincinnati
NCT00607789
Trial to Test Effectiveness of Depression Intervention for Mistreated Older Adults
Weill Medical College of Cornell University
NCT04258579
Medications for the Treatment of Dysthymic Disorder and Double Depression
Oregon Health and Science University
NCT00234312
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
Friends Research Institute
NCT03864653
Acute Aerobic Exercise and Neuroplasticity in Depression
Medical University of South Carolina
NCT02839837
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
National Institute of Mental Health (NIMH)
NCT00697268
Supporting Our Valued Adolescents Pilot Randomized Controlled Trial
University of Pittsburgh
NCT03318666
Improving Quality of Life for Veterans With Stroke and Psychological Distress
VA Office of Research and Development
NCT03645759
Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment
New York State Psychiatric Institute
NCT00456014
Physiologic Monitoring of Antidepressant Treatment Response
University of California, Los Angeles
NCT00759317
Mindfulness-Based Stress Reduction for Metro Nashville Public School Employees
Vanderbilt University Medical Center
NCT05051969
Electronic Self-management Resource Training for Mental Health
Case Western Reserve University
NCT01304862
Neuromodulation to Facilitate the Effect of Ketamine
The Neuroscience Center
NCT01816958
Heart-Smile Training Intensive Introduction Program
Cambridge Health Alliance
NCT05564533
Support for Caregivers of Older Adults With Cognitive Decline
State University of New York at Buffalo
NCT04787068
AZD6765 for Treatment Resistant Depression
AstraZeneca
NCT00491686
Pharmacokinetic Study of Bupropion Hydrochloride Products With Different Release Patterns
University of Michigan
NCT02078180
Motivational Interviewing and Cognitive Behavioral Therapy-based Intervention for Cardiovascular Disease Prevention Amongst American Indians With Diabetic and Depressive Symptoms
University of Washington
NCT01892124
WILD 5 Wellness, A 30-Day Intervention
Beloit College
NCT03328520
Mindfulness Intervention to Study the Neurobiology of Depression
University of Illinois at Chicago
NCT01905267
Bright Light: A Novel Treatment for Anxiety
University of South Carolina
NCT01064700
Enhancing Delivery of Problem Solving Therapy Using SmartPhone Technology
VA Office of Research and Development
NCT01891734
Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors
Ohio State University Comprehensive Cancer Center
NCT01929720
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Mclean Hospital
NCT00125957
Improving Depression Via E-Health Access (IDEA) Study
University of Michigan
NCT04689568
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.