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COMPLETED Phase 2

Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer

NCT00005850 · View on ClinicalTrials.gov ↗

Study Summary

This trial is designed to test the efficacy of fluoxetine to improve patient's quality of life during chemotherapy. An innovative application of a selective serotonin reuptake inhibitor may modulate the effects of fatigue, anxiety and depression which worsen quality of life.

Interventions

  • DRUG cisplatin
  • DRUG gemcitabine hydrochloride
  • DRUG fluoxetine

Study Locations (20)

Florida

  • Broward General Medical Center — Fort Lauderdale
  • Memorial Regional Hospital Comprehensive Cancer Center — Hollywood
  • Florida Hospital Cancer Institute — Orlando
  • Helen and Harry Gray Cancer Institute at Good Samaritan Medical Center — West Palm Beach

Illinois

  • University of Chicago Cancer Research Center — Chicago
  • Louis A. Weiss Memorial Hospital — Chicago
  • West Suburban Center for Cancer Care — River Forest
  • Saint Anthony Medical Center — Rockford

Massachusetts

  • Massachusetts General Hospital Cancer Center — Boston
  • Beth Israel Medical Center — Boston

Missouri

  • Ellis Fischel Cancer Center - Columbia — Columbia
  • Barnes-Jewish Hospital — St Louis

Alabama

  • Northeast Alabama Regional Medical Center — Anniston

California

  • Veterans Affairs Medical Center - San Diego — San Diego

District of Columbia

  • Veterans Affairs Medical Center - Washington, DC — Washington D.C.

Indiana

  • Fort Wayne Medical Oncology and Hematology, Incorporated — Fort Wayne

Trial Details

FieldValue
Enrollment Target 21 participants
Start Date 2001-08
Est. Completion 2003-09
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00005850

The ClinicalTrials.gov registry entry for NCT00005850 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00005850 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Illinois, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00005850 about?

NCT00005850 is a clinical study titled "Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer". This trial is designed to test the efficacy of fluoxetine to improve patient's quality of life during chemotherapy. An innovative application of a selective serotonin reuptake inhibitor may modulate the effects of fatigue, anxiety and depression which worsen quality of life.

What is the current status of trial NCT00005850?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 21 participants. The study started on 2001-08. Estimated completion is 2003-09.

What conditions does trial NCT00005850 study?

This clinical trial studies the following conditions: Depression, Lung Cancer, Fatigue, Anxiety Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00005850?

The interventions under investigation include: cisplatin (DRUG), gemcitabine hydrochloride (DRUG), fluoxetine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00005850?

This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00005850 being conducted?

This trial has 20 study locations across Alabama, California, District of Columbia, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial