Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 14 of 14
Increasing Physical Activity Among Breast Cancer Survivors With Depression
University of Texas Southwestern Medical Center
NCT02781051
Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders
University of South Florida
NCT03552328
Brief Inpatient Psychotherapy for Depression
Cedars-Sinai Medical Center
NCT03091582
Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
New York State Psychiatric Institute
NCT01748955
Buprenorphine for Late-Life Treatment Resistant Depression
University of Pittsburgh
NCT01071538
Wellbutrin XL Effects on SSRIs Induced Changes
Indiana University School of Medicine
NCT00456820
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
New York State Psychiatric Institute
NCT04244786
Meditation for Depression
University of California, San Francisco
NCT01671436
TMS for Adults With Autism and Depression
Medical University of South Carolina
NCT02939560
HOPE Pilot for Veterans With Complex Diabetes
Michael E. DeBakey VA Medical Center
NCT01274715
rTMS in Treatment Resistant Depression
Emory University
NCT02080507
Unilateral Massage as a Potential Treatment for Depression
University of Arizona
NCT01937897
Video-visit Behavior Therapy for Anxiety and Depression in Youth
San Diego State University
NCT05417412
Ketamine for Depression and Suicide Risk
Mayo Clinic
NCT02094898
Affect Treatment for Depression and Anxiety (TAD Pilot)
University of California, Los Angeles
NCT06488859
Daily Weight Feedback for Wheelchair Users to Promote Weight Loss
Jonathan Pearlman
NCT03264248
Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
Massachusetts General Hospital
NCT01527981
Virtual Reality at End-of-life
State University of New York at Buffalo
NCT06149429
The Feasibility of Engage Therapy With Video Support for Homebound Older Adults
Weill Medical College of Cornell University
NCT05346055
An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression
Mayo Clinic
NCT00587639
Healthy Heart Habits
Hennepin Healthcare Research Institute
NCT04158219
Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
New York State Psychiatric Institute
NCT00338806
Companion Dog Walking for ICU Survivor Health
University of Missouri, Kansas City
NCT05820308
Cranial Electrotherapy Stimulation (CES) Therapy
The University of Texas Health Science Center at San Antonio
NCT02453347
Venlafaxine for Depression in Alzheimer's Disease (DIADs-3)
Johns Hopkins University
NCT01609348
Electrical Stimulation of the Internal Capsule for Intractable Depression
Butler Hospital
NCT01069952
Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for Cancer
Scott A. Irwin, MD, PhD
NCT02836288
Cognitive Behavioral Therapy for Insomnia with RTMS
Medical University of South Carolina
NCT04258618
Feasibility of Egg-Based Diet Interventions and Assessing Perinatal Mental Health
University of Idaho
NCT05619445
Collaborative Care Intervention for Cancer Caregivers
University of Pittsburgh
NCT02944136
The Depression in Alzheimer's Disease Study (DIADS)
Johns Hopkins University
NCT00009191
Gabapentin For the Control of Hot Flashes in Women With Breast Cancer
Gary Morrow
NCT00022074
Antidepressant Treatment of AIDS Related Depression.
GEIGY Pharmaceuticals
NCT00000390
Cytokine-Associated Depression and Social Pain
University of California, Los Angeles
NCT00949845
Intervention to Decrease Anxiety in Parents of Infants in the Neonatal Intensive Care Unit (NICU)
Stanford University
NCT00186472
Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
Memorial Sloan Kettering Cancer Center
NCT00014482
Major Depression and Inflammatory Risk Markers for Coronary Heart Disease
National Center for Research Resources (NCRR)
NCT00037505
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.