Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 10 of 14
Understanding the Efficacy of Mobile Apps as Intervention for Depression in Adults When Deployed as Part of Primary Care.
Actualize Therapy
NCT03500536
A Public Health Program to Reduce Risk of Antepartum Depression
East Carolina University
NCT02144844
Omega-3 for Depression and Other Cardiac Risk Factors - 2
Washington University School of Medicine
NCT02021669
Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes
Indiana University
NCT03371940
Conexion: A Localized Information Resource on Diabetes and Depression for a Low-income Hispanic Community
Columbia University
NCT03984929
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Indiana University
NCT02213900
Depression and Congestive Heart Failure in Outpatients.
VA Office of Research and Development
NCT00321269
Nature and Health: How Does Lifestyle and Environment Affect Health and Wellness
Stanford University
NCT06001697
Amplification of Positivity to Enhance Social Connections in Anxiety and Depression
University of California, San Diego
NCT04945239
Genetic and Biochemical Markers of Interferon-Induced Depression.
US Department of Veterans Affairs
NCT00252538
Magnetic Stimulation Therapy for Treating Vascular Depression
University of Iowa
NCT00044798
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression
Duke University
NCT00339066
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Emory University
NCT01941706
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
Tal Medical
NCT02452892
Holistic Approaches to Depression
Butler Hospital
NCT01384916
Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults
University of Pennsylvania
NCT03441399
Culturally Sensitive Collaborative Treatment for Depressed Chinese Americans
Massachusetts General Hospital
NCT00227929
Efficacy of Telepsychiatry in the Treatment of Depression
US Department of Veterans Affairs
NCT00012610
An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)
University of California, Los Angeles
NCT01641146
IntelliCare in College Students - Implementation (ICCS-I)
Northwestern University
NCT04108429
Effectiveness of Culturally Based Congruent Care in Treating Hispanics With Major Depressive Disorder
New York State Psychiatric Institute
NCT00247195
Clinical Trial of Memantine for Major Depression
National Institute of Mental Health (NIMH)
NCT00040261
Multifaceted Depression and Cardiovascular Program
University of Southern California
NCT02069912
Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device
Mclean Hospital
NCT00578383
Brain Imaging in Depression
National Institute of Mental Health (NIMH)
NCT00050700
Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00006204
Comparing Delivery Methods of Cognitive Behavioral Therapy for Depressed African-American Dementia Caregivers
Robert L. Glueckauf
NCT00769769
Efficacy and Tolerability of Riluzole in Treatment Resistant Depression
Yale University
NCT01204918
Organized Self-management Support for Chronic Depression
Kaiser Permanente
NCT00169286
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
Washington University School of Medicine
NCT01693874
Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease
Weill Medical College of Cornell University
NCT00601055
The Safety and Efficacy of Nexalin Trans-cranial Electrical Stimulation Stimulation for the Treatment of Depression
University of Pennsylvania
NCT03277846
Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes
Harvard University
NCT03112265
Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant
Northside Hospital
NCT01084694
Ability to Cope With Type 1 Diabetes
Baylor College of Medicine
NCT00206362
Meru Health Program Versus Waitlist Control for Adults With Depression
Meru Health
NCT04738084
Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women
University of New Mexi
NCT00375297
Examining the Link Between Depression and Seasonal Allergies
University of Maryland, Baltimore
NCT00770068
Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.
Samueli Institute for Information Biology
NCT01752010
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
Massachusetts General Hospital
NCT00183677
The MEADOW PROJECT (Mending the Effects of Alcohol and Depression on Women) and The Bridge Program (Connecting Recovery Treatment and Behavioral Health)
University of Rochester
NCT00851669
Psychological Treatments for Scleroderma
Johns Hopkins University
NCT00007267
Use of Conversation and Acoustic Signals in Measuring Depression Severity
Boston Medical Center
NCT00831935
A Mobile Health Solution for Homework During CBT
University of South Florida
NCT04931199
Combination Treatment Study for Memory Impairment and Depression
New York State Psychiatric Institute
NCT01658228
Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
US Department of Veterans Affairs
NCT00223652
Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians
University of New Mexi
NCT02124694
The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)
Soul Medicine Institute
NCT00641394
Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans
VA Office of Research and Development
NCT00805532
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.