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NCT00050700 · ClinicalTrials.gov registry record
Brain Imaging in Depression
A clinical trial of Depression and Bipolar Disorder, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 107
- Enrollment target
- 1
- Study location
NCT00050700: Completed study of Depression and Bipolar Disorder, sponsored by National Institute of Mental Health (NIMH).
NCT00050700 is a study of Depression and Bipolar Disorder that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 107 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00050700, a study of Depression and Bipolar Disorder, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 107 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. The cholinergic system involves the regulation of neurotransmitters and the brain receptors to which they bind. Evidence suggests that the cholinergic system may play a role in the development of depression. Acetylcholine is a neurotransmitter that binds to certain brain receptors called muscarinic cholinergic receptors. Cholinomimetic drugs (drugs that stimulate the cholinergic system) often exacerbate depressive symptoms in people with mood disorders and in healthy individuals. This increase in depressive symptoms may be caused by stimulation of muscarinic acetylcholine receptors (mAChRs), but further study is needed to confirm this. This study will use positron emission tomography (PET) and magnetic resonance imaging (MRI) to study the function of mAChRs in individuals with depression. Participants in this study will undergo a physical examination, psychiatric interviews, neuropsychological tests, PET and MRI scans, and rating scales of depression, anxiety, and negative thinking symptoms. Questions about behavior and functioning will be asked and blood samples will be collected for genetic analysis.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 107 participants |
| Start Date | 2002-12-16 |
| Est. Completion | 2010-05-14 |
What the finished NCT00050700 record still lists
NCT00050700 is an observational study that tracks outcomes without assigning an intervention. The registered 107 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (86% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 0 interventions.
NCT00050700 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00050700 about?
NCT00050700 is a clinical study titled "Brain Imaging in Depression". The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. The cholinergic system involves the regulation of neurotransmitters and the brain receptors to which they bind. Evidence sug...
What is the current status of trial NCT00050700?
This trial is currently completed. The enrollment target is 107 participants. The study started on 2002-12-16. Estimated completion is 2010-05-14.
What conditions does trial NCT00050700 study?
This clinical trial studies the following conditions: Depression, Bipolar Disorder.
Who is sponsoring clinical trial NCT00050700?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00050700 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00050700's enrollment target sits among peer trials
107 315th of 679 higher than 364 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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