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NCT04945239 · ClinicalTrials.gov registry record · NA
Amplification of Positivity to Enhance Social Connections in Anxiety and Depression
A NA study of Depression and Anxiety Disorders and Symptoms, sponsored by University of California, San Diego.
- Completed
- Registry status
- NA
- Development phase
- 134
- Enrollment target
- 1
- Study location
NCT04945239 is a NA study of Depression and Anxiety Disorders and Symptoms that has completed, run by University of California, San Diego. The registered enrollment target is 134 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04945239, a NA study of Depression and Anxiety Disorders and Symptoms, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- NA
- Development phase
- 134 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- Amplification of Positivity (AMP) -- intended to enhance positive social connections in individuals with elevated anxiety and/or depression. Social relationship impairments are common and debilitating consequences of anxiety and depression. Existing treatments have some beneficial impact on social functioning; however, many people continue to have few and/or poor quality relationships following treatment, even after experiencing symptom relief. This study will evaluate the effects of AMP on the brain systems that have been shown to be important for establishing positive connections with others. Approximately 100 individuals (ages 18-55) seeking treatment for anxiety or depression will participate in this study. Participants will be randomly assigned with equal probability to either AMP or stress management training (SMT) (6 sessions each). Participants will be assessed at baseline and post-treatment and compared on measures assessing brain responses to social reward (primary outcome), as well as physiological, behavioral, and emotional responses to social reward (secondary outcomes). It is hypothesized that the AMP group will experience greater increases from pre- to post-treatment in activity in brain systems that regulate the processing of social reward cues (e.g., striatum) relative to participants in the SMT group. It is also hypothesized that changes in brain activation to social reward from pre- to post-treatment will be correlated with the degree of improvement in social connectedness.
Conditions Studied
Interventions
- BEHAVIORAL Amplification of Positivity Training (6 Sessions)
- BEHAVIORAL Stress Management Training (6 Sessions)
Study Locations (1)
California
- Altman Clinical and Translational Research Institute - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 134 participants |
| Start Date | 2021-03-29 |
| Est. Completion | 2024-03-25 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04945239
The ClinicalTrials.gov registry entry for NCT04945239 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 134 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (83% lower). The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Amplification of Positivity Training (6 Sessions) is the first listed.
NCT04945239 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT04945239 about?
NCT04945239 is a clinical study titled "Amplification of Positivity to Enhance Social Connections in Anxiety and Depression". The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- Amplification of Positivity (AMP) -- intended to enhance positive social connections in individuals with elevated anxiety and/or depression. Social relationship impairments are common and debilitating cons...
What is the current status of trial NCT04945239?
This trial is currently completed. It is a NA study. The enrollment target is 134 participants. The study started on 2021-03-29. Estimated completion is 2024-03-25.
What conditions does trial NCT04945239 study?
This clinical trial studies the following conditions: Depression, Anxiety Disorders and Symptoms.
What interventions are being tested in trial NCT04945239?
The interventions under investigation include: Amplification of Positivity Training (6 Sessions) (BEHAVIORAL), Stress Management Training (6 Sessions) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04945239?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04945239 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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