Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 9 of 14
Antidepressant Use During Pregnancy
University of Pittsburgh
NCT00279370
Toddler Overweight Prevention Study Among Low-Income Families
University of Maryland, Baltimore
NCT02615158
Low-intensity Stepped Care for Internalizing Distress
Indiana University
NCT05441111
An Integrated Model of Primary Care in Mental Health
US Department of Veterans Affairs
NCT00013260
Sunshine 2 Study for Women With Diabetes
Loyola University
NCT01904032
ADAPT: Addressing Depression and Pain Together
University of Pittsburgh
NCT01124188
Reward-Related Processes and Brain Function
National Institute of Mental Health (NIMH)
NCT00029588
Mothers With a History of Depression and Their 10-14 Year Old Daughters
Stanford University
NCT01129752
Telephone Calls for Health for Homebound Older Adults
University of Texas at Austin
NCT04595708
Effectiveness of Supplemental Calcium in Preventing Postpartum Depression
Oregon Health and Science University
NCT00228033
Family-centered Mental Health Promotion Intervention
University of Massachusetts, Amherst
NCT04453709
Personalized Antidepressant Adherence Strategies For Depressed Elders
Weill Medical College of Cornell University
NCT01301859
Comparison of Three Electroconvulsive Therapy (ECT) Techniques for the Treatment of Major Depression
University of Medicine and Dentistry of New Jersey
NCT00069407
Preventing Maternal Depression In Head Start
Boston Medical Center
NCT01298804
Reducing Symptoms of Depression in Low-Income Mothers
University of North Carolina, Chapel Hill
NCT00074789
Intervention Trial to Reduce Mental Health Disparities in Latina Immigrant Women
University of Washington
NCT03545282
Therapy for Depressed Elders With Thought Problems
University of Washington
NCT00052091
Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders
AltheaDx
NCT02411123
Reducing Health Risk Behavior and Improving Health in Adolescents With Depression
University of California, Los Angeles
NCT00461539
Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder
Veterans Medical Research Foundation
NCT01158001
Chatbot for Depression, Anxiety, and Eating Disorders
Dartmouth-Hitchcock Medical Center
NCT06013137
Spanish Intervention for Caregivers of Veterans With Stroke
VA Office of Research and Development
NCT03142841
The Clinic Treatment Project
Judge Baker Children's Center
NCT01178554
Shared Decision-Making for Elderly Depressed Primary Care Patients
Weill Medical College of Cornell University
NCT01031134
Preventing Post-Stroke Depression
Robert G. Robinson
NCT00071643
Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression
Maurizio Fava, MD
NCT00101452
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Brief Cognitive Behavioral Therapy (CBT) for Pediatric Anxiety and Depression in Primary Care
San Diego State University
NCT01147614
Loving-Kindness Meditation for PTSD
VA Office of Research and Development
NCT01962714
Integrating Depression Services Into DM Management
University of Pennsylvania
NCT01098253
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD
Oregon Research Institute
NCT00680966
Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression
New York State Psychiatric Institute
NCT00487500
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression
Mayo Clinic
NCT02286440
Brief Peer Supported webSTAIR Compared to Enhanced Wait List
Palo Alto Veterans Institute for Research
NCT04286165
Perimenopausal Estrogen Replacement Therapy Study
University of North Carolina, Chapel Hill
NCT01308814
Stress and Coping in Caregivers of Younger Patients With Cancer
Wake Forest University Health Sciences
NCT02725385
Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans
Veterans Medical Research Foundation
NCT01253044
Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment
University of Nebraska
NCT00536172
Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression
Boston Medical Center
NCT02262377
Depression and Self-care in Heart Failure
Washington University School of Medicine
NCT01028625
Treatments for Depression: Drug Versus Psychotherapy
University of Pennsylvania
NCT00043550
Text Based Digital Interventions Prompting Enjoyable and Healthy Behaviors
Florida State University
NCT06492824
Intravenous Ketamine Plus Neurocognitive Training for Depression
Rebecca Price
NCT03237286
Collaborative Care for Women Veterans
VA Office of Research and Development
NCT02950961
Study of a Self-Help Depression Skills Program for College-Aged Youth
Kaiser Permanente
NCT00145054
Randomized Control Trial of an Animal-Assisted Intervention With Adjudicated Youth
Wayne State University
NCT01594606
Participatory Messaging in the UCLA Psychiatry Partial Hospitalization and Intensive Outpatient Programs
University of California, Los Angeles
NCT02708940
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
Massachusetts General Hospital
NCT00338767
Cognitive Behavioral Therapy for Depression: Helping Clients Learn New Skills
Ohio State University
NCT04673513
Comparison of Depression Interventions After Acute Coronary Syndrome
Columbia University
NCT01032018
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.