Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 9 of 14
Antidepressant Use During Pregnancy
University of Pittsburgh
NCT00279370
Toddler Overweight Prevention Study Among Low-Income Families
University of Maryland, Baltimore
NCT02615158
Low-intensity Stepped Care for Internalizing Distress
Indiana University
NCT05441111
An Integrated Model of Primary Care in Mental Health
US Department of Veterans Affairs
NCT00013260
Sunshine 2 Study for Women With Diabetes
Loyola University
NCT01904032
ADAPT: Addressing Depression and Pain Together
University of Pittsburgh
NCT01124188
Reward-Related Processes and Brain Function
National Institute of Mental Health (NIMH)
NCT00029588
Mothers With a History of Depression and Their 10-14 Year Old Daughters
Stanford University
NCT01129752
Telephone Calls for Health for Homebound Older Adults
University of Texas at Austin
NCT04595708
Effectiveness of Supplemental Calcium in Preventing Postpartum Depression
Oregon Health and Science University
NCT00228033
Family-centered Mental Health Promotion Intervention
University of Massachusetts, Amherst
NCT04453709
Personalized Antidepressant Adherence Strategies For Depressed Elders
Weill Medical College of Cornell University
NCT01301859
Comparison of Three Electroconvulsive Therapy (ECT) Techniques for the Treatment of Major Depression
University of Medicine and Dentistry of New Jersey
NCT00069407
Preventing Maternal Depression In Head Start
Boston Medical Center
NCT01298804
Reducing Symptoms of Depression in Low-Income Mothers
University of North Carolina, Chapel Hill
NCT00074789
Intervention Trial to Reduce Mental Health Disparities in Latina Immigrant Women
University of Washington
NCT03545282
Therapy for Depressed Elders With Thought Problems
University of Washington
NCT00052091
Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders
AltheaDx
NCT02411123
Reducing Health Risk Behavior and Improving Health in Adolescents With Depression
University of California, Los Angeles
NCT00461539
Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder
Veterans Medical Research Foundation
NCT01158001
Chatbot for Depression, Anxiety, and Eating Disorders
Dartmouth-Hitchcock Medical Center
NCT06013137
Spanish Intervention for Caregivers of Veterans With Stroke
VA Office of Research and Development
NCT03142841
The Clinic Treatment Project
Judge Baker Children's Center
NCT01178554
Shared Decision-Making for Elderly Depressed Primary Care Patients
Weill Medical College of Cornell University
NCT01031134
Preventing Post-Stroke Depression
Robert G. Robinson
NCT00071643
Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression
Maurizio Fava, MD
NCT00101452
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Brief Cognitive Behavioral Therapy (CBT) for Pediatric Anxiety and Depression in Primary Care
San Diego State University
NCT01147614
Loving-Kindness Meditation for PTSD
VA Office of Research and Development
NCT01962714
Integrating Depression Services Into DM Management
University of Pennsylvania
NCT01098253
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD
Oregon Research Institute
NCT00680966
Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression
New York State Psychiatric Institute
NCT00487500
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression
Mayo Clinic
NCT02286440
Brief Peer Supported webSTAIR Compared to Enhanced Wait List
Palo Alto Veterans Institute for Research
NCT04286165
Perimenopausal Estrogen Replacement Therapy Study
University of North Carolina, Chapel Hill
NCT01308814
Stress and Coping in Caregivers of Younger Patients With Cancer
Wake Forest University Health Sciences
NCT02725385
Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans
Veterans Medical Research Foundation
NCT01253044
Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment
University of Nebraska
NCT00536172
Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression
Boston Medical Center
NCT02262377
Depression and Self-care in Heart Failure
Washington University School of Medicine
NCT01028625
Treatments for Depression: Drug Versus Psychotherapy
University of Pennsylvania
NCT00043550
Text Based Digital Interventions Prompting Enjoyable and Healthy Behaviors
Florida State University
NCT06492824
Intravenous Ketamine Plus Neurocognitive Training for Depression
Rebecca Price
NCT03237286
Collaborative Care for Women Veterans
VA Office of Research and Development
NCT02950961
Study of a Self-Help Depression Skills Program for College-Aged Youth
Kaiser Permanente
NCT00145054
Randomized Control Trial of an Animal-Assisted Intervention With Adjudicated Youth
Wayne State University
NCT01594606
Participatory Messaging in the UCLA Psychiatry Partial Hospitalization and Intensive Outpatient Programs
University of California, Los Angeles
NCT02708940
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
Massachusetts General Hospital
NCT00338767
Cognitive Behavioral Therapy for Depression: Helping Clients Learn New Skills
Ohio State University
NCT04673513
Comparison of Depression Interventions After Acute Coronary Syndrome
Columbia University
NCT01032018
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.