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Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 11 of 14
Hyperthermic Yoga for Depressive Symptoms
Massachusetts General Hospital
NCT02607514
The Effect of Exercise on Mood After Traumatic Brain Injury
University of Washington
NCT00571545
Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression
Weill Medical College of Cornell University
NCT00926653
A Randomized-Controlled Trial to Investigate the Effect of a Novel Music Therapy Application to Reduce Anxiety and Stress
SoundMind
NCT06021821
Study of 6(S)-5-MTHF Among Selective Serotonin Reuptake Inhibitor-Resistant Outpatients With Major Depressive Disorder
George I. Papakostas
NCT00955955
The "PC-LIGHT" Study
Northwestern University
NCT03419585
Evaluating Technology Enabled Services in Perinatal Depression
Northwestern University
NCT05525689
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
Johns Hopkins University
NCT05187117
Reducing Depression in Dementia Caregivers
University of Missouri, St. Louis
NCT00056316
Programmed Environmental Illumination (PEI) of Hospital Rooms to Prevent/Reduce Cancer-Related Fatigue
Icahn School of Medicine at Mount Sinai
NCT03198754
A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Weill Medical College of Cornell University
NCT03265210
Clinical and Biological Characteristics of Psychotic Depression
Stanford University
NCT00576095
Neurobiological Underpinnings of Placebo Response in Depression
Massachusetts General Hospital
NCT02562430
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Dartmouth-Hitchcock Medical Center
NCT04637581
Mobile App for Mood in Pregnancy (Ginger iO)
University of Pennsylvania
NCT02761720
MEditation for Post Stroke Depression
The University of Texas Health Science Center, Houston
NCT03239132
Effectiveness of a Unified Transdiagnostic Treatment in Routine Care
Boston University
NCT02944994
Combined Interventions for Treating Depression and Chronic Back Pain
Kaiser Permanente
NCT00158275
Platelet Function in Patients Treated With SSRI and Non-SSRI Antidepressants
National Institutes of Health Clinical Center (CC)
NCT00009568
Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse
University of Rochester
NCT00257400
Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
University of Michigan
NCT01545843
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
University of Utah
NCT03335358
Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study
Beth Israel Deaconess Medical Center
NCT00906581
Rapid Antidepressant Effects of Ketamine in Major Depression
National Institute of Mental Health (NIMH)
NCT00088699
Trial of Asthma Self-Management Education in Patients With Depressive Symptoms
Hospital for Special Surgery, New York
NCT01708070
Development of a Mind Body Program for Obese Knee Osteoarthritis Patients With Comorbid Depression
University of Kentucky
NCT04334278
Effects of Open-label Placebos on COVID-related Psychological Health
Michigan State University
NCT05035550
Mindfulness, Yoga, and Cardiovascular Disease
The Cleveland Clinic
NCT00696852
Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults With Emotional Distress (Phase 1)
University of Illinois at Chicago
NCT04524104
Mental Health Intervention for Elderly Abuse Victims
Weill Medical College of Cornell University
NCT02283385
Disseminating Evidence-based Mood Disorder Chronic Care Models
University of Michigan
NCT01615458
Preventing Depression and Anxiety: A Cystic Fibrosis-Specific Cognitive Behavioral Therapy Intervention
Massachusetts General Hospital
NCT03992027
A Study of Infliximab for Treatment Resistant Major Depression
Emory University
NCT00463580
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Child And Adolescent Outpatients With Major Depressive Disorder
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00619619
Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial
New York University
NCT02696109
Rhodiola Rosea Therapy of Major Depressive Disorder
University of Pennsylvania
NCT01098318
Neurocognitive Predictors of Behavioral Therapy Response in Depression
Laureate Institute for Brain Research
NCT02602340
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
The Treatment of Depression With Yoga and Walking
Boston University
NCT02907476
Investigating LIFUP in Anhedonic Depression
University of California, Los Angeles
NCT06285474
The Effects of Smell on Mood and Physical Responses
National Center for Complementary and Integrative Health (NCCIH)
NCT00097253
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
VA Office of Research and Development
NCT02697435
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
VA Office of Research and Development
NCT02248675
Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder
Massachusetts General Hospital
NCT00595387
Effects of Mindfulness-based Cognitive Therapy on Brain Mechanisms in Depression
Massachusetts General Hospital
NCT02200341
Internet and Telephone Support Intervention for Stroke Caregivers
VA Office of Research and Development
NCT04348851
Pilot Study of Annie Text Messaging for Depression Treatment Adherence
VA Office of Research and Development
NCT03930849
Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
Johns Hopkins University
NCT03431493
Ketamine for the Treatment of Depression in Parkinson's Disease
Yale University
NCT04944017
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.