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NCT06374225 · ClinicalTrials.gov registry record · NA
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
A NA study of Critical Illness and Pathologic Processes, sponsored by University of Colorado, Denver.
- Active
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 4
- Study locations
NCT06374225: Active NA study of Critical Illness and Pathologic Processes, sponsored by University of Colorado, Denver.
NCT06374225 is a NA study of Critical Illness and Pathologic Processes that is active but no longer recruiting, run by University of Colorado, Denver. The registered enrollment target is 300 participants, below the 3,135-participant average among 91 other Critical Illness trials with a reported enrollment target (90% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06374225, a NA study of Critical Illness and Pathologic Processes, is active but no longer recruiting, sponsored by University of Colorado, Denver.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 4
- Study locations
Study Summary
This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the first 72 hours of acute injury or illness, compared to standard provider-driven methods (manual titration with SpO2 target of 90-96%).
Primary Outcome
The primary endpoint is proportion of time spent within the targeted normoxemia range, defined as an oxygen saturation (SpO2) of 90-96% (target 93%), as measured by continuous non-invasive pulse oximetry, during the first 72 hours after randomization, censored at hospital discharge, escalation to high flow nasal oxygen/mechanical ventilation, or death if prior to 72 hours.
Conditions Studied
Interventions
- DEVICE Automated Titration (O2matic)
Study Locations (4)
Colorado
- University of Colorado - Aurora
North Carolina
- Atrium Health Wake Forest Baptist Medical Center - Winston-Salem
Oregon
- Oregon Health and Sciences University - Portland
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2024-04-29 |
| Est. Completion | 2026-05-01 |
| Phase | NA |
What the registry record for NCT06374225 still lists
NCT06374225 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 3,135-participant average among 91 other Critical Illness trials with a reported enrollment target (90% lower).
The record links to 4 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention - of which Automated Titration (O2matic) is the first listed.
NCT06374225 reports a single indexed study location in Colorado, North Carolina, Oregon.
Frequently Asked Questions
What is clinical trial NCT06374225 about?
NCT06374225 is a clinical study titled "Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention". This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the first 72 hours of acute injury or illness, compared to standard provider-...
What is the current status of trial NCT06374225?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2024-04-29. Estimated completion is 2026-05-01.
What conditions does trial NCT06374225 study?
This clinical trial studies the following conditions: Critical Illness, Pathologic Processes, Wounds and Injury, Disease Attributes.
What interventions are being tested in trial NCT06374225?
The interventions under investigation include: Automated Titration (O2matic) (DEVICE).
Who is sponsoring clinical trial NCT06374225?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06374225 being conducted?
This trial has 4 study locations across Colorado, North Carolina, Oregon, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06374225's enrollment target sits among peer trials
300 40th of 91 higher than 52 of 91 other Critical Illness trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Critical Illness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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