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NCT03139695 · ClinicalTrials.gov registry record
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
A clinical trial of Critical Illness and Mechanical Ventilation Complication, sponsored by Wake Forest University Health Sciences.
- Completed
- Registry status
- 75
- Enrollment target
- 1
- Study location
NCT03139695: Completed study of Critical Illness and Mechanical Ventilation Complication, sponsored by Wake Forest University Health Sciences.
NCT03139695 is a study of Critical Illness and Mechanical Ventilation Complication that has completed, run by Wake Forest University Health Sciences. The registered enrollment target is 75 participants, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03139695, a study of Critical Illness and Mechanical Ventilation Complication, has completed, sponsored by Wake Forest University Health Sciences.
- COMPLETED
- Registry status
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is safe to get off the ventilator or be extubated. They use clinical assessment of the patient's ability to breathe spontaneously and make use of some breathing parameters to make the judgment. Most of the time, a patient can come off the ventilator and do well, but sometimes muscle weakness from sickness can affect the patient's ability to breathe adequately once ventilator support is discontinued. If that occurs, the patient may have to be put back on the ventilator and the physician will suggest some changes to help muscles get stronger. A simple, non-invasive test that can assess respiratory muscle state before taking patients off the ventilator to see if their muscles look healthy can help distinguish which patients may not be ready to be extubated. There are currently several tests available to assess muscle strength, in particular muscles that help in breathing like the intercostal muscles and diaphragm. The study will test the use of Ultrasonography (Ultrasound) as a non-invasive test to assess the muscles of respiration. This test will also help the investigators test physical therapies and interventions of mechanical ventilation that can help patients strengthen the muscles while waiting for extubation.
Primary Outcome
Muscle thickness will be measured at end inspiration and end expiration images of diaphragm to ascertain the thickening fraction of the diaphragm. Progression of muscle thickening fraction during mechanical ventilation will be assessed.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Ultrasound
Study Locations (1)
North Carolina
- Wake Forest Univesity Health Sciences - Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2012-11 |
| Est. Completion | 2016-07-01 |
What the finished NCT03139695 record still lists
NCT03139695 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention - of which Ultrasound is the first listed.
NCT03139695 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT03139695 about?
NCT03139695 is a clinical study titled "Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients". Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is safe to get off the ventilator or be extubated. They use clinical asse...
What is the current status of trial NCT03139695?
This trial is currently completed. The enrollment target is 75 participants. The study started on 2012-11. Estimated completion is 2016-07-01.
What conditions does trial NCT03139695 study?
This clinical trial studies the following conditions: Critical Illness, Mechanical Ventilation Complication, Injury of Diaphragm.
What interventions are being tested in trial NCT03139695?
The interventions under investigation include: Ultrasound (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03139695?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03139695 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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participants (enrollment target), bucketed by value
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