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NCT07215520 · ClinicalTrials.gov registry record · Phase 2

Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults

A Phase 2 study of COVID-19, sponsored by CastleVax.

Recruiting
Registry status
Phase 2
Development phase
200
Enrollment target
2
Study locations

NCT07215520 is a Phase 2 study of COVID-19 that is actively recruiting participants, run by CastleVax. The registered enrollment target is 200 participants, below the 55,213-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states.

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The verdict

NCT07215520, a Phase 2 study of COVID-19, is actively recruiting participants, sponsored by CastleVax.

RECRUITING
Registry status
Phase 2
Development phase
200 participants
Enrollment target
2
Study locations

Study Summary

A Double-blind, Randomized, Controlled, Phase 2a Study to Evaluate the Safety and Tolerability of a Newcastle Disease Virus-based Mucosal Vaccine (NDV-HXP-S-KP.2) Relative to an Approved Systemic mRNA Vaccine in Previously Vaccinated Adults

Conditions Studied

COVID-19

Interventions

  • BIOLOGICAL NDV-HXP-S-KP.2
  • BIOLOGICAL COVID-19 mRNA Vaccine

Study Locations (2)

Colorado

  • Skylight Health Research - Colorado Springs

Massachusetts

  • Skylight Health Research - Burlington

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2025-11-03
Est. Completion 2026-08-19
Phase Phase 2

Sponsor

CastleVax

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07215520

The ClinicalTrials.gov registry entry for NCT07215520 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 55,213-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The listed sponsor is CastleVax, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 2 interventions - of which NDV-HXP-S-KP.2 is the first listed.

NCT07215520 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Colorado, Massachusetts.

Frequently Asked Questions

What is clinical trial NCT07215520 about?

NCT07215520 is a clinical study titled "Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults". A Double-blind, Randomized, Controlled, Phase 2a Study to Evaluate the Safety and Tolerability of a Newcastle Disease Virus-based Mucosal Vaccine (NDV-HXP-S-KP.2) Relative to an Approved Systemic mRNA Vaccine in Previously Vaccinated Adults

What is the current status of trial NCT07215520?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2025-11-03. Estimated completion is 2026-08-19.

What conditions does trial NCT07215520 study?

This clinical trial studies the following conditions: COVID-19.

What interventions are being tested in trial NCT07215520?

The interventions under investigation include: NDV-HXP-S-KP.2 (BIOLOGICAL), COVID-19 mRNA Vaccine (BIOLOGICAL).

Who is sponsoring clinical trial NCT07215520?

This trial is sponsored by CastleVax, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07215520 being conducted?

This trial has 2 study locations across Colorado, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.