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ClinicalTrials.gov 57 recruiting now official registry

Coronary Artery Disease clinical trials

57 of 220 indexed Coronary Artery Disease trials are currently recruiting.

220 US clinical trials · 57 currently recruiting

Coronary Artery Disease is the subject of 220 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 17 of these trials.

The research picture

Coronary Artery Disease has 220 registered US clinical trials, 57 of them open to new participants right now, about 26% of the total.

57
recruiting participants now
26%
of trials open to enrollment
42
in Phase 3–4 (later-stage)
17
top sponsor: University of Florida
Phase 16Phase 29Phase 317Phase 425

Active & Recent Trials

220 total, page 4 of 5

COMPLETED NA 184 participants

Comparing TR Band to Statseal in Conjunction With TR Band

VA Long Beach Healthcare System

NCT03028025

COMPLETED NA 179 participants

Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

Johns Hopkins University

NCT00353795

COMPLETED 178 participants

Evaluation Using Computed Tomography Angiography (CTA) to Investigate and Detect Atherosclerotic Graft Disease (ELUCIDATE)

Corewell Health East

NCT00580008

COMPLETED NA 170 participants

Sapphire 3 CTO Study

OrbusNeich

NCT06358508

COMPLETED Phase 2 150 participants

Familiarization and Safety Study of PB127 Ultrasound Contrast Agent

Point Biomedical

NCT00594698

COMPLETED NA 150 participants

Stress CT Perfusion in Patients With Chest Pain

University of Chicago

NCT01969916

COMPLETED NA 150 participants

Left Versus Right Radial Artery and Radiation Exposure in Patients With Predictors of Trans-radial Failure

NYU Langone Health

NCT01707524

COMPLETED NA 145 participants

Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

Shockwave Medical

NCT05966662

COMPLETED Phase 4 137 participants

Effect of Evolocumab on Coronary Plaque Characteristics

Annapoorna Kini

NCT04710368

COMPLETED 123 participants

Age and Endothelial Progenitor Cell Mobilization

Emory University

NCT00585949

COMPLETED Phase 3 120 participants

Cardiovascular Outcomes Of Diet Counseling

The Camelot Foundation

NCT00324545

COMPLETED NA 115 participants

Secondary Prevention After Coronary Bypass Surgery

Jeffrey Kramer, MD

NCT00843089

COMPLETED Phase 3 110 participants

Myocardial Ischemia and Transfusion Pilot

Rutgers, The State University of New Jersey

NCT01167582

COMPLETED Phase 2 110 participants

Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent

Marc Sakwa, MD

NCT01681095

COMPLETED NA 107 participants

Abbott Next Generation Drug Eluting Stent 48mm Study

Abbott Medical Devices

NCT04282148

COMPLETED Phase 4 105 participants

Ticagrelor With and Without Aspirin in Patients With Diabetes Mellitus

University of Florida

NCT04484259

COMPLETED NA 102 participants

Rapid Stress/Rest Single-Day Tc-99m Sestamibi Myocardial Single Photon Emission Computed Tomography

St. Luke's-Roosevelt Hospital Center

NCT01434641

COMPLETED 102 participants

Comparing Blood Loss, RBC Transfusions and Inflammatory Marker Changes Among Methods of CPB

Baylor Research Institute

NCT01083914

COMPLETED NA 100 participants

Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

NYU Langone Health

NCT02135939

COMPLETED NA 96 participants

Vitamin D Repletion in Coronary Artery Disease

Seth I. Sokol, M.D.

NCT01570309

COMPLETED NA 94 participants

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions in Small Vessels

Boston Scientific Corporation

NCT01498692

COMPLETED NA 93 participants

AngioSculpt® Coronary Bifurcation Study

AngioScore

NCT00686647

COMPLETED Early Phase 1 92 participants

Aspirin Resistance in Coronary Artery Disease

Vanderbilt University

NCT00753935

COMPLETED Phase 4 87 participants

Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy

Annapoorna Kini

NCT01567826

COMPLETED Phase 4 87 participants

Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease

University of Florida

NCT02287909

COMPLETED NA 80 participants

Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease

Johns Hopkins University

NCT04272060

COMPLETED NA 80 participants

Evaluation of Pharmacist Interventions in Lipid Management for Secondary Prevention

Wake Forest University Health Sciences

NCT06647238

COMPLETED 75 participants

HCR vs. CABG Study

Emory University

NCT02892474

COMPLETED 75 participants

Observational Study of the Association Between Periodontal Disease and Cardiovascular Disease

Texas Tech University Health Sciences Center

NCT02177591

COMPLETED NA 74 participants

Reducing Radioisotope Dose: the Half-Dose CZT Study

S.M.Chang, MD

NCT01518777

COMPLETED NA 71 participants

Side Branch FFR After Provisional Stenting

Icahn School of Medicine at Mount Sinai

NCT03115580

COMPLETED 68 participants

Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery

Emory University

NCT04221594

COMPLETED Phase 4 65 participants

Prasugrel Re-load Strategies

University of Florida

NCT01201772

COMPLETED NA 60 participants

The Triglyceride Lowering Effect of an Omega-3 Fat (DHA) in Addition to Statin Therapy for Patients With CAD or Diabetes

Maine Center for Lipids and Cardiovascular Health

NCT00360217

COMPLETED 60 participants

Expression of Angiogenic Factors in Myocardial Tissue

University of Virginia

NCT01414621

COMPLETED NA 60 participants

Prophylactic Maze to Prevent Atrial Fibrillation in Adult Cardiac Surgery

Corewell Health West

NCT03604432

COMPLETED Phase 3 60 participants

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

Kathirvel Subramaniam

NCT03270514

COMPLETED NA 59 participants

A Behavioral Science-Enhanced PHysician-led Remote Group Exercise InTervention for Women With Coronary Artery Disease

Brigham and Women's Hospital

NCT05611333

COMPLETED 57 participants

Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI

Emory University

NCT00166179

COMPLETED NA 54 participants

Effect of Ile-Pro-Pro (IPP) on Endothelial Function in Patients With Coronary Artery Disease

Boston University

NCT00924157

COMPLETED NA 52 participants

Effects of Almonds On Endothelial Function In Patients With Coronary Artery Disease

Boston University

NCT01038362

COMPLETED Phase 2 52 participants

High Ticagrelor Loading Dose in STEMI

University of Florida

NCT01898442

COMPLETED 50 participants

HemoSonics-UVA HemoSonics-UVA Cardiac Surgery Clinical Study Protocol

University of Virginia

NCT02456467

COMPLETED Phase 2 48 participants

To Evaluate Safety, Pharmacokinetics and Pharmacodynamics of MEDI6012 in Subjects With Stable Coronary Artery Disease

MedImmune

NCT02601560

COMPLETED Phase 1 46 participants

Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia

St. Louis University

NCT01161121

COMPLETED 43 participants

Comorbid Insomnia and Sleep Disordered Breathing in Patients Undergoing Cardiac Rehabilitation

Mayo Clinic

NCT04992676

COMPLETED Phase 4 41 participants

18F-fluoride (18F-NaF) PET for Identifying Coronary Atherosclerotic Plaques

Cedars-Sinai Medical Center

NCT02607748

COMPLETED 40 participants

VasoStat vs. TR Band for Radial Hemostasis

Forge Medical

NCT04163471

COMPLETED 40 participants

Platelet Sub-study of the TWILIGHT Trial

Juan Badimon

NCT04001374

COMPLETED Phase 4 40 participants

Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI

University of Florida

NCT03437044

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 9
Phase 3 17
Phase 4 25

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Coronary Artery Disease Trial Landscape

220 indexed Coronary Artery Disease studies · 57 recruiting (26%).

Phase mix: 42 late (III/IV) vs 15 early (I/II).

Top sponsor: University of Florida (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Coronary Artery Disease?

PlainTrial tracks 220 US clinical trials for Coronary Artery Disease, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Coronary Artery Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.