Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05966662 · ClinicalTrials.gov registry record · NA
Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)
A NA study of Coronary Artery Disease and Myocardial Infarction, sponsored by Shockwave Medical.
- Completed
- Registry status
- NA
- Development phase
- 145
- Enrollment target
- 18
- Study locations
NCT05966662: Completed NA study of Coronary Artery Disease and Myocardial Infarction, sponsored by Shockwave Medical.
NCT05966662 is a NA study of Coronary Artery Disease and Myocardial Infarction that has completed, run by Shockwave Medical. The registered enrollment target is 145 participants, below the 1,286-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (89% lower). The trial reports 18 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05966662, a NA study of Coronary Artery Disease and Myocardial Infarction, has completed, sponsored by Shockwave Medical.
- COMPLETED
- Registry status
- NA
- Development phase
- 145 participants
- Enrollment target
- 18
- Study locations
Study Summary
This investigational device exemption (IDE) study is to assess the safety and effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary lesions prior to stenting.
Primary Outcome
Freedom from MACE within 30 days of the index procedure. MACE is defined as a composite occurrence of: cardiac death, myocardial infarction (MI), target vessel revascularization (TVR) after the completion of the index procedure.
Conditions Studied
Interventions
- DEVICE IVL with Shockwave C2+ 2Hz Coronary IVL Catheter
Study Locations (18)
New York
- Northwell Health/Lenox Hill - New York
- St. Francis Hospital - Roslyn
Pennsylvania
- UPMC Pinnacle Health - Harrisburg
- WellSpan Health - York - York
Texas
- Baylor Scott and White Research Institute - Dallas
- Methodist Hospital - San Antonio
Alabama
- Heart Center Research - Huntsville
California
- Scripps Clinic - La Jolla
District of Columbia
- Medstar Washington Hospital Center - Washington D.C.
Florida
- Memorial Health - Hollywood
Georgia
- Wellstar Kennestone Hospital - Marietta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 145 participants |
| Start Date | 2023-12-08 |
| Est. Completion | 2025-12-19 |
| Phase | NA |
What the finished NCT05966662 record still lists
NCT05966662 is an interventional study that assigns participants to a tested intervention. The registered 145 participants enrollment target is mid-sized for trials with a published cap, below the 1,286-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (89% lower).
The record links to 2 conditions, with Coronary Artery Disease appearing as the primary indexed condition, and to 1 intervention - of which IVL with Shockwave C2+ 2Hz Coronary IVL Catheter is the first listed.
NCT05966662 lists 18 locations in 15 states (New York, Pennsylvania, Texas).
Frequently Asked Questions
What is clinical trial NCT05966662 about?
NCT05966662 is a clinical study titled "Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)". This investigational device exemption (IDE) study is to assess the safety and effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary lesions prior to stenting.
What is the current status of trial NCT05966662?
This trial is currently completed. It is a NA study. The enrollment target is 145 participants. The study started on 2023-12-08. Estimated completion is 2025-12-19.
What conditions does trial NCT05966662 study?
This clinical trial studies the following conditions: Coronary Artery Disease, Myocardial Infarction.
What interventions are being tested in trial NCT05966662?
The interventions under investigation include: IVL with Shockwave C2+ 2Hz Coronary IVL Catheter (DEVICE).
Who is sponsoring clinical trial NCT05966662?
This trial is sponsored by Shockwave Medical, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05966662 being conducted?
This trial has 18 study locations across Alabama, California, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Coronary Artery Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05966662's enrollment target sits among peer trials
145 134th of 219 higher than 86 of 219 other Coronary Artery Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Coronary Artery Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
RECRUITING · NA
-
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
RECRUITING · NA
-
PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
RECRUITING · NA
-
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
RECRUITING · NA
-
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health
RECRUITING · NA
-
Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02688959 · 145 participants · NA
Motor Attention Training for Attention Deficit Hyperactivity Disorder (ADHD)
- NCT03586609 · 145 participants · Phase 2
Venetoclax, Cladribine, Low Dose Cytarabine, and Azacitidine in Treating Patients With Previously Untreated Acute Myeloid Leukemia
- NCT03767595 · 145 participants · NA
ProACT Post-Approval Study
- NCT03808337 · 145 participants · Phase 2
Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI