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NCT04001374 · ClinicalTrials.gov registry record
Platelet Sub-study of the TWILIGHT Trial
A clinical trial of Coronary Artery Disease and Myocardial Infarction, sponsored by Juan Badimon.
- Completed
- Registry status
- 40
- Enrollment target
- 1
- Study location
NCT04001374: Completed study of Coronary Artery Disease and Myocardial Infarction, sponsored by Juan Badimon.
NCT04001374 is a study of Coronary Artery Disease and Myocardial Infarction that has completed, run by Juan Badimon. The registered enrollment target is 40 participants, below the 1,287-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04001374, a study of Coronary Artery Disease and Myocardial Infarction, has completed, sponsored by Juan Badimon.
- COMPLETED
- Registry status
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
TWILIGHT study is a multicenter RCT comparing treatment with ticagrelor alone versus ticagrelor plus aspirin in high-risk patients after PCI. All patients will receive DAPT (ticagrelor plus aspirin) for the initial 3 months post-PCI and then be randomized to either Ticagrelor alone OR Ticagrelor plus Aspirin DAPT. To investigate the pharmacodynamic effects of the two treatments in this trial, a 'Platelet Sub-study' will be conducted only at the Mount Sinai Medical Center. The sub-study will recruit randomized patients from the TWILIGHT Trial at Mount Sinai and conduct specialized blood tests at randomization and one month thereafter. The aim of the Platelet Sub-study is to compare the antithrombotic effects of Ticagrelor alone versus Ticagrelor plus Aspirin using an ex vivo model of thrombosis (Badimon Chamber).
Primary Outcome
Thrombus area measured 1-6 months after randomization
Conditions Studied
Interventions
- DRUG Ticagrelor
- DRUG ASA
Study Locations (1)
New York
- Icahn School of Medicine at Mount Sinai - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2015-06-28 |
| Est. Completion | 2018-02-28 |
What the finished NCT04001374 record still lists
NCT04001374 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,287-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Coronary Artery Disease appearing as the primary indexed condition, and to 2 interventions - of which Ticagrelor is the first listed.
NCT04001374 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT04001374 about?
NCT04001374 is a clinical study titled "Platelet Sub-study of the TWILIGHT Trial". TWILIGHT study is a multicenter RCT comparing treatment with ticagrelor alone versus ticagrelor plus aspirin in high-risk patients after PCI. All patients will receive DAPT (ticagrelor plus aspirin) for the initial 3 months post-PCI and then be randomized to either Ticagrelor alone OR Ticagrelor plu...
What is the current status of trial NCT04001374?
This trial is currently completed. The enrollment target is 40 participants. The study started on 2015-06-28. Estimated completion is 2018-02-28.
What conditions does trial NCT04001374 study?
This clinical trial studies the following conditions: Coronary Artery Disease, Myocardial Infarction.
What interventions are being tested in trial NCT04001374?
The interventions under investigation include: Ticagrelor (DRUG), ASA (DRUG).
Who is sponsoring clinical trial NCT04001374?
This trial is sponsored by Juan Badimon, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04001374 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04001374's enrollment target sits among peer trials
40 188th of 219 higher than 27 of 219 other Coronary Artery Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Coronary Artery Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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