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Arthroplasty, Replacement, Knee
Open-data reference.
12 US clinical trials · 1 currently recruiting
Active & Recent Trials
Real-component Vs All-cement Articulating Spacers for Periprosthetic Knee Infection
Northwestern University
NCT06293352
TracPatch in Total Knee Arthroplasty
University of Miami
NCT03466476
Metal Ion Concentrations After Total Knee Arthroplasty
Mayo Clinic
NCT06447922
CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
Stony Brook University
NCT05666479
X-3 Polyethylene Survival Outcomes Study
Mayo Clinic
NCT00493792
Preventing Persistent Post-Surgical Pain and Dysfunction
Barbara A Rakel
NCT03965897
Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study
Stryker Orthopaedics
NCT00957723
Traditional vs Oral Fluid Management in Total Knee Arthroplasty
Colorado Joint Replacement
NCT03719378
Study to Evaluate ACB Versus FNB Early Postoperative Period Functional Outcomes After TKA
George Macrinici
NCT02218814
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
Northwestern University
NCT02746874
Music Therapy Versus Control for Total Knee Arthroplasty
University of Alabama at Birmingham
NCT03569397
Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty
The University of Tennessee, Knoxville
NCT04103515
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Arthroplasty, Replacement, Knee Trial Landscape
ClinicalTrials.gov lists 12 US studies indexed under Arthroplasty, Replacement, Knee, and 1 of those are currently open to recruitment — roughly 8% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Arthroplasty, Replacement, Knee shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Arthroplasty, Replacement, Knee is led by Northwestern University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Arthroplasty, Replacement, Knee?
PlainTrial tracks 12 US clinical trials for Arthroplasty, Replacement, Knee, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Arthroplasty, Replacement, Knee?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.