Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02700425 · ClinicalTrials.gov registry record · NA
His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy
A NA study of Congestive Heart Failure, sponsored by University of Chicago.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
- 8
- Study locations
NCT02700425: Completed NA study of Congestive Heart Failure, sponsored by University of Chicago.
NCT02700425 is a NA study of Congestive Heart Failure that has completed, run by University of Chicago. The registered enrollment target is 41 participants, below the 329-participant average among 51 other Congestive Heart Failure trials with a reported enrollment target (88% lower). The trial reports 8 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02700425, a NA study of Congestive Heart Failure, has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
- 8
- Study locations
Study Summary
The goal of this study is to compare the effectiveness of pacing from a physiologic His bundle (HB) lead position versus with the standard coronary sinus (CS) lead position in subjects with heart failure undergoing cardiac resynchronization therapy (CRT). While placement of left ventricular leads via the coronary sinus has anatomic limitations, we hypothesis that the achievement of QRS narrowing with His bundle capture will be superior for improving systolic function by echocardiographic indices (ejection fraction and strain) and quality of life and decreased rehospitalization and mortality.
Primary Outcome
Change in left ventricular ejection fraction (LVEF) as measured by echocardiography in a blinded core lab.
Conditions Studied
Interventions
- DEVICE CRT Pacemaker
Study Locations (8)
Illinois
- Northwestern University - Chicago
- Rush University Medical Center - Chicago
- The University of Chicago - Chicago
- Edward Hospital - Naperville
California
- The University of California, Los Angeles - Los Angeles
Indiana
- Indiana University - Indianapolis
Kentucky
- Baptist Health Louisville - Louisville
Pennsylvania
- Geisinger Wyoming Valley Medical Center - Wilkes-Barre
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2016-05-17 |
| Est. Completion | 2020-07-31 |
| Phase | NA |
What the finished NCT02700425 record still lists
NCT02700425 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 329-participant average among 51 other Congestive Heart Failure trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Congestive Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which CRT Pacemaker is the first listed.
NCT02700425 lists 8 locations in 5 states (Illinois, California, Indiana).
Frequently Asked Questions
What is clinical trial NCT02700425 about?
NCT02700425 is a clinical study titled "His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy". The goal of this study is to compare the effectiveness of pacing from a physiologic His bundle (HB) lead position versus with the standard coronary sinus (CS) lead position in subjects with heart failure undergoing cardiac resynchronization therapy (CRT). While placement of left ventricular leads vi...
What is the current status of trial NCT02700425?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2016-05-17. Estimated completion is 2020-07-31.
What conditions does trial NCT02700425 study?
This clinical trial studies the following conditions: Congestive Heart Failure.
What interventions are being tested in trial NCT02700425?
The interventions under investigation include: CRT Pacemaker (DEVICE).
Who is sponsoring clinical trial NCT02700425?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02700425 being conducted?
This trial has 8 study locations across California, Illinois, Indiana, Kentucky, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congestive Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02700425's enrollment target sits among peer trials
41 40th of 51 higher than 12 of 51 other Congestive Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congestive Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Stress and Congestive Heart Failure
RECRUITING · NA
-
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
RECRUITING · NA
-
Care Transitions App for Patients With Multiple Chronic Conditions
RECRUITING · NA
-
SyncAV Post-Market Trial
ACTIVE NOT RECRUITING · NA
-
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
ACTIVE NOT RECRUITING · NA
-
Congestive Heart Failure Pilot Study Utilizing Wireless Home Scale and Daily Symptom Monitoring
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03449238 · 41 participants · Phase 1
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
- NCT03900793 · 41 participants · Phase 1
Losartan + Sunitinib in Treatment of Osteosarcoma
- NCT04082520 · 41 participants · Phase 2
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy
- NCT04220190 · 41 participants · Phase 2
RAPA-501 Therapy for ALS
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI