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His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy
NCT02700425 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to compare the effectiveness of pacing from a physiologic His bundle (HB) lead position versus with the standard coronary sinus (CS) lead position in subjects with heart failure undergoing cardiac resynchronization therapy (CRT). While placement of left ventricular leads via the coronary sinus has anatomic limitations, we hypothesis that the achievement of QRS narrowing with His bundle capture will be superior for improving systolic function by echocardiographic indices (ejection fraction and strain) and quality of life and decreased rehospitalization and mortality.
Conditions Studied
Interventions
- DEVICE CRT Pacemaker
Study Locations (8)
Illinois
- Northwestern University — Chicago
- Rush University Medical Center — Chicago
- The University of Chicago — Chicago
- Edward Hospital — Naperville
California
- The University of California, Los Angeles — Los Angeles
Indiana
- Indiana University — Indianapolis
Kentucky
- Baptist Health Louisville — Louisville
Pennsylvania
- Geisinger Wyoming Valley Medical Center — Wilkes-Barre
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2016-05-17 |
| Est. Completion | 2020-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02700425
The ClinicalTrials.gov registry entry for NCT02700425 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Chicago, which has 846 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Congestive Heart Failure appearing as the primary indexed condition, and to 1 intervention — of which CRT Pacemaker is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02700425 reports 8 study locations spanning 5 distinct geographic areas — top geographies include Illinois, California, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02700425 about?
NCT02700425 is a clinical study titled "His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy". The goal of this study is to compare the effectiveness of pacing from a physiologic His bundle (HB) lead position versus with the standard coronary sinus (CS) lead position in subjects with heart failure undergoing cardiac resynchronization therapy (CRT). While placement of left ventricular leads vi...
What is the current status of trial NCT02700425?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2016-05-17. Estimated completion is 2020-07-31.
What conditions does trial NCT02700425 study?
This clinical trial studies the following conditions: Congestive Heart Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02700425?
The interventions under investigation include: CRT Pacemaker (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02700425?
This trial is sponsored by University of Chicago, which has 846 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02700425 being conducted?
This trial has 8 study locations across California, Illinois, Indiana, Kentucky, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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