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NCT05598333 · ClinicalTrials.gov registry record · Phase 2
Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure
A Phase 2 study of Congestive Heart Failure, sponsored by AskBio.
- Active
- Registry status
- Phase 2
- Development phase
- 150
- Enrollment target
- 20
- Study locations
NCT05598333: Active Phase 2 study of Congestive Heart Failure, sponsored by AskBio.
NCT05598333 is a Phase 2 study of Congestive Heart Failure that is active but no longer recruiting, run by AskBio. The registered enrollment target is 150 participants, below the 327-participant average among 51 other Congestive Heart Failure trials with a reported enrollment target (54% lower). The trial reports 20 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05598333, a Phase 2 study of Congestive Heart Failure, is active but no longer recruiting, sponsored by AskBio.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 150 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in males and females age \>18 years with non-ischemic cardiomyopathy and NYHA Class III symptoms of HF. Subjects will be randomized into one of three treatment groups in a 1:1:1
Conditions Studied
Interventions
- DRUG AB-1002
Study Locations (20)
California
- University of California Irvine Medical Center - Irvine
- University of California San Diego - La Jolla
- University of California San Francisco - San Francisco
Florida
- Baycare Medical Group - Clearwater
- University of Miami - Coral Gables
- University of Florida - Gainesville
Massachusetts
- Massachusetts General Hospital - Boston
- Brigham and Women's Hospital - Boston
Minnesota
- Minneapolis Heart Institute Foundation - Minneapolis
- Mayo Clinic - Minnesota - Rochester
Missouri
- Aurora Saint Luke's Health System - Kansas City
- St. Louis University - St Louis
Alabama
- Cardiology P.C. Birmingham - Birmingham
Arizona
- University of Arizona Sarvor Heart Center - Tucson
Georgia
- Augusta University - Augusta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2023-10-20 |
| Est. Completion | 2030-12-31 |
| Phase | Phase 2 |
What the registry record for NCT05598333 still lists
NCT05598333 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 327-participant average among 51 other Congestive Heart Failure trials with a reported enrollment target (54% lower).
The record links to 1 condition, with Congestive Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which AB-1002 is the first listed.
NCT05598333 names 20 study sites across 13 states, led by California, Florida, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05598333 about?
NCT05598333 is a clinical study titled "Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure". This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in males and females age \>18 years with non-ischemic cardiomyopathy and NYH...
What is the current status of trial NCT05598333?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2023-10-20. Estimated completion is 2030-12-31.
What conditions does trial NCT05598333 study?
This clinical trial studies the following conditions: Congestive Heart Failure.
What interventions are being tested in trial NCT05598333?
The interventions under investigation include: AB-1002 (DRUG).
Who is sponsoring clinical trial NCT05598333?
This trial is sponsored by AskBio, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05598333 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congestive Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05598333's enrollment target sits among peer trials
150 24th of 51 higher than 27 of 51 other Congestive Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congestive Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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