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NCT07255729 · ClinicalTrials.gov registry record
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer
A clinical trial of Colon Cancer, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- 400
- Enrollment target
- 1
- Study location
NCT07255729: Recruiting study of Colon Cancer, sponsored by City of Hope Medical Center.
NCT07255729 is a study of Colon Cancer that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 400 participants, below the 4,452-participant average among 97 other Colon Cancer trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07255729, a study of Colon Cancer, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- 400 participants
- Enrollment target
- 1
- Study location
Study Summary
Recent studies have highlighted the potential benefits of neoadjuvant chemotherapy (NAC) in colon cancer; however, its indication is generally limited to cases corresponding to pathological stage IIB or higher. Accurately identifying such high-risk cases before surgery remains challenging using conventional clinical diagnostics alone. Therefore, we hypothesized that integrating molecular biomarkers with preoperative clinical assessment could provide a more precise and sensitive evaluation of tumor aggressiveness. In this context, we focused on exosomal microRNAs, which are actively secreted from tumor cells and remain stable in circulation, and aimed to develop a machine learning-based biomarker panel. To achieve this, we initiated a multicenter study utilizing preoperative plasma samples to establish a reliable biomarker model for risk stratification and treatment decision-making in colon cancer.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Diagnostic Test: EXPOSE assay（Small RNA-seq of exosomal miRNAs）
- DIAGNOSTIC_TEST Diagnostic Test: EXPOSE RT-qPCR panel
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2025-01-15 |
| Est. Completion | 2026-06-18 |
What NCT07255729 shows while recruiting
NCT07255729 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 4,452-participant average among 97 other Colon Cancer trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Colon Cancer appearing as the primary indexed condition, and to 2 interventions - of which Diagnostic Test: EXPOSE assay（Small RNA-seq of exosomal miRNAs） is the first listed.
NCT07255729 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07255729 about?
NCT07255729 is a clinical study titled "An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer". Recent studies have highlighted the potential benefits of neoadjuvant chemotherapy (NAC) in colon cancer; however, its indication is generally limited to cases corresponding to pathological stage IIB or higher. Accurately identifying such high-risk cases before surgery remains challenging using conv...
What is the current status of trial NCT07255729?
This trial is currently recruiting. The enrollment target is 400 participants. The study started on 2025-01-15. Estimated completion is 2026-06-18.
What conditions does trial NCT07255729 study?
This clinical trial studies the following conditions: Colon Cancer.
What interventions are being tested in trial NCT07255729?
The interventions under investigation include: Diagnostic Test: EXPOSE assay（Small RNA-seq of exosomal miRNAs） (DIAGNOSTIC_TEST), Diagnostic Test: EXPOSE RT-qPCR panel (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07255729?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07255729 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colon Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07255729's enrollment target sits among peer trials
400 22nd of 97 higher than 75 of 97 other Colon Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colon Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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