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NCT07321106 · ClinicalTrials.gov registry record · Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer
A Phase 1 study of Colorectal Cancer and Colon Cancer, sponsored by Cartography Biosciences.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 80
- Enrollment target
- 4
- Study locations
NCT07321106: Recruiting Phase 1 study of Colorectal Cancer and Colon Cancer, sponsored by Cartography Biosciences.
NCT07321106 is a Phase 1 study of Colorectal Cancer and Colon Cancer that is actively recruiting participants, run by Cartography Biosciences. The registered enrollment target is 80 participants, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (95% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07321106, a Phase 1 study of Colorectal Cancer and Colon Cancer, is actively recruiting participants, sponsored by Cartography Biosciences.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 80 participants
- Enrollment target
- 4
- Study locations
Study Summary
This study will investigate the safety, tolerability, pharmacokinetics, and anti-tumor activity of CBI-1214 in participants with advanced or metastatic Microsatellite Stable (MSS)/Microsatellite Instability Low (MSI-L) Colorectal Cancer
Primary Outcome
Incidence and severity of TEAEs, TRAEs, and TESAEs; changes in vital signs, physical examinations, and clinical laboratory parameters per NCI-CTCAE v5.0.
Conditions Studied
Interventions
- BIOLOGICAL CBI-1214
Study Locations (4)
California
- Valkyrie Clinical Trials - Los Angeles
Michigan
- START Midwest - Grand Rapids
Texas
- NEXT Oncology - San Antonio
Virginia
- NEXT Oncology - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-01-15 |
| Est. Completion | 2029-10 |
| Phase | Phase 1 |
What NCT07321106 shows while recruiting
NCT07321106 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (95% lower).
The record links to 7 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 1 intervention - of which CBI-1214 is the first listed.
NCT07321106 reports a single indexed study location in California, Michigan, Texas.
Frequently Asked Questions
What is clinical trial NCT07321106 about?
NCT07321106 is a clinical study titled "A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer". This study will investigate the safety, tolerability, pharmacokinetics, and anti-tumor activity of CBI-1214 in participants with advanced or metastatic Microsatellite Stable (MSS)/Microsatellite Instability Low (MSI-L) Colorectal Cancer
What is the current status of trial NCT07321106?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2026-01-15. Estimated completion is 2029-10.
What conditions does trial NCT07321106 study?
This clinical trial studies the following conditions: Colorectal Cancer, Colon Cancer, Colorectal Cancer (CRC), CRC, Advanced Colorectal Cancer.
What interventions are being tested in trial NCT07321106?
The interventions under investigation include: CBI-1214 (BIOLOGICAL).
Who is sponsoring clinical trial NCT07321106?
This trial is sponsored by Cartography Biosciences, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07321106 being conducted?
This trial has 4 study locations across California, Michigan, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07321106's enrollment target sits among peer trials
80 230th of 381 higher than 148 of 381 other Colorectal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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