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ClinicalTrials.gov 34 recruiting now official registry

Colon Cancer clinical trials

34 of 99 indexed Colon Cancer trials are currently recruiting.

99 US clinical trials · 34 currently recruiting

Colon Cancer is the subject of 99 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.

The research picture

Colon Cancer has 99 registered US clinical trials, 34 of them open to new participants right now, about 34% of the total.

34
recruiting participants now
34%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
6
top sponsor: National Cancer Institute (NCI)
Phase 126Phase 211Phase 34

Active & Recent Trials

99 total, page 2 of 2

ACTIVE NOT RECRUITING 51 participants

A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors

Memorial Sloan Kettering Cancer Center

NCT03432806

ACTIVE NOT RECRUITING Phase 1 50 participants

CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab

Anup Kasi

NCT05121038

ACTIVE NOT RECRUITING Phase 2 48 participants

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

University of Colorado, Denver

NCT04963283

ACTIVE NOT RECRUITING Phase 1 44 participants

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

HUYABIO International

NCT05485974

ACTIVE NOT RECRUITING Phase 1 42 participants

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS

Immunophotonics

NCT05688280

ACTIVE NOT RECRUITING Phase 1 24 participants

Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer

M.D. Anderson Cancer Center

NCT05722327

ACTIVE NOT RECRUITING NA 20 participants

Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer

City of Hope Medical Center

NCT02293954

ACTIVE NOT RECRUITING NA 20 participants

Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors

Wake Forest University Health Sciences

NCT06340503

ACTIVE NOT RECRUITING Phase 1 14 participants

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

GlaxoSmithKline

NCT06710847

ACTIVE NOT RECRUITING NA 7 participants

Oncology Episode Payment Model in Hawaii

University of Pennsylvania

NCT03523546

COMPLETED 200,000 participants

General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)

University Hospitals Cleveland Medical Center

NCT00622557

COMPLETED NA 5,460 participants

Mailed FIT Outreach 2022

Abramson Cancer Center at Penn Medicine

NCT05341622

COMPLETED NA 2,004 participants

Study of Colorectal Cancer Screening Options

Kaiser Permanente

NCT05987709

COMPLETED NA 1,900 participants

Adherence to Colon Cancer Screening (ACCS)

Ohio State University Comprehensive Cancer Center

NCT02112747

COMPLETED NA 1,831 participants

Online Study of Colorectal Cancer and Prostate Cancer Screening Decision Making

University of North Carolina, Chapel Hill

NCT01558583

COMPLETED NA 1,267 participants

Patient Navigator Project

H. Lee Moffitt Cancer Center and Research Institute

NCT00375024

COMPLETED Phase 3 621 participants

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults

Norgine

NCT02254486

COMPLETED NA 500 participants

Impact of a Novel Patient Educational Booklet on Colonoscopy Quality

VA Greater Los Angeles Healthcare System

NCT00975247

COMPLETED Phase 3 386 participants

BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy

Braintree Laboratories

NCT00756548

COMPLETED NA 375 participants

Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer

Wake Forest University Health Sciences

NCT01656044

COMPLETED NA 302 participants

Men Together Making a Difference: Health Promotion for Black Men

University of Pennsylvania

NCT02572414

COMPLETED NA 284 participants

Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer

Ohio State University Comprehensive Cancer Center

NCT01801059

COMPLETED NA 238 participants

Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)

Indiana University

NCT03462706

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 1 202 participants

Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer

Amgen

NCT00625651

COMPLETED NA 183 participants

FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study

Kaiser Permanente

NCT03291951

COMPLETED NA 180 participants

Reducing VA No-Shows: Evaluation of Predictive Overbooking Applied to Colonoscopy

VA Office of Research and Development

NCT01639443

COMPLETED NA 178 participants

Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting

University of California, Davis

NCT01729416

COMPLETED 120 participants

Understanding the Value of Community Vital Signs in Primary Care

Virginia Commonwealth University

NCT02512835

COMPLETED 115 participants

GI SPORE Colon Biosample Protocol

University of Michigan

NCT02243267

COMPLETED Phase 1 107 participants

Safety of BKM120 Monotherapy in Advanced Solid Tumor Patients

Novartis Pharmaceuticals

NCT01068483

COMPLETED 93 participants

Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients

M.D. Anderson Cancer Center

NCT00508846

COMPLETED NA 85 participants

Latino Peers as Patient Navigators for Colon Cancer Screening

Icahn School of Medicine at Mount Sinai

NCT02226107

COMPLETED Phase 3 69 participants

An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy

Corewell Health West

NCT00467922

COMPLETED NA 52 participants

Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy

Washington University School of Medicine

NCT05427214

COMPLETED Phase 1 50 participants

CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer

David Bajor, MD

NCT02861300

COMPLETED Phase 2 48 participants

Clinical Trial in Patients With Metastatic Colorectal Cancer

Mast Therapeutics

NCT00081627

COMPLETED Phase 3 46 participants

Promoting Physical Activity After Colorectal Cancer

The Miriam Hospital

NCT00230646

COMPLETED NA 40 participants

Hybrid APC Assisted EMR for Large Colon Polyps

Milton S. Hershey Medical Center

NCT03390907

COMPLETED NA 30 participants

Sleep Coach: A Mobile App to Address Insomnia Symptoms Among Cancer Survivors

University of Michigan Rogel Cancer Center

NCT04827459

COMPLETED 29 participants

Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy

UNC Lineberger Comprehensive Cancer Center

NCT01789983

COMPLETED 25 participants

Genetic Investigation of Solid Tumors Cohort

Scripps Translational Science Institute

NCT01005225

COMPLETED Phase 1 23 participants

Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies

Novita Pharmaceuticals

NCT03199586

COMPLETED 22 participants

Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

National Human Genome Research Institute (NHGRI)

NCT02767986

COMPLETED Phase 2 20 participants

Clinical and Translational Study of STA-9090

Memorial Sloan Kettering Cancer Center

NCT01111838

COMPLETED Phase 2 20 participants

Cellular Immune Augmentation in Colon and Rectal Cancer

University of California, Irvine

NCT00257322

COMPLETED Phase 1 11 participants

Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer

National Cancer Institute (NCI)

NCT03384316

COMPLETED Phase 2 10 participants

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

National Cancer Institute (NCI)

NCT03801915

COMPLETED Phase 2 5 participants

Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity

St. Luke's-Roosevelt Hospital Center

NCT01163552

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 11
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Colon Cancer Trial Landscape

99 indexed Colon Cancer studies · 34 recruiting (34%).

Phase mix: 4 late (III/IV) vs 37 early (I/II).

Top sponsor: National Cancer Institute (NCI) (6 trials), 9 others listed. 49 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Colon Cancer?

PlainTrial tracks 99 US clinical trials for Colon Cancer, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Colon Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.