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Colon Cancer clinical trials
34 of 99 indexed Colon Cancer trials are currently recruiting.
99 US clinical trials · 34 currently recruiting
Colon Cancer is the subject of 99 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.
The research picture
Colon Cancer has 99 registered US clinical trials, 34 of them open to new participants right now, about 34% of the total.
- 34
- recruiting participants now
- 34%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 6
- top sponsor: National Cancer Institute (NCI)
Active & Recent Trials
99 total, page 2 of 2
A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors
Memorial Sloan Kettering Cancer Center
NCT03432806
CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab
Anup Kasi
NCT05121038
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
University of Colorado, Denver
NCT04963283
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
HUYABIO International
NCT05485974
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
Immunophotonics
NCT05688280
Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer
M.D. Anderson Cancer Center
NCT05722327
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
City of Hope Medical Center
NCT02293954
Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors
Wake Forest University Health Sciences
NCT06340503
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
GlaxoSmithKline
NCT06710847
Oncology Episode Payment Model in Hawaii
University of Pennsylvania
NCT03523546
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
University Hospitals Cleveland Medical Center
NCT00622557
Mailed FIT Outreach 2022
Abramson Cancer Center at Penn Medicine
NCT05341622
Study of Colorectal Cancer Screening Options
Kaiser Permanente
NCT05987709
Adherence to Colon Cancer Screening (ACCS)
Ohio State University Comprehensive Cancer Center
NCT02112747
Online Study of Colorectal Cancer and Prostate Cancer Screening Decision Making
University of North Carolina, Chapel Hill
NCT01558583
Patient Navigator Project
H. Lee Moffitt Cancer Center and Research Institute
NCT00375024
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults
Norgine
NCT02254486
Impact of a Novel Patient Educational Booklet on Colonoscopy Quality
VA Greater Los Angeles Healthcare System
NCT00975247
BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy
Braintree Laboratories
NCT00756548
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
Wake Forest University Health Sciences
NCT01656044
Men Together Making a Difference: Health Promotion for Black Men
University of Pennsylvania
NCT02572414
Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer
Ohio State University Comprehensive Cancer Center
NCT01801059
Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)
Indiana University
NCT03462706
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer
Amgen
NCT00625651
FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study
Kaiser Permanente
NCT03291951
Reducing VA No-Shows: Evaluation of Predictive Overbooking Applied to Colonoscopy
VA Office of Research and Development
NCT01639443
Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting
University of California, Davis
NCT01729416
Understanding the Value of Community Vital Signs in Primary Care
Virginia Commonwealth University
NCT02512835
GI SPORE Colon Biosample Protocol
University of Michigan
NCT02243267
Safety of BKM120 Monotherapy in Advanced Solid Tumor Patients
Novartis Pharmaceuticals
NCT01068483
Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients
M.D. Anderson Cancer Center
NCT00508846
Latino Peers as Patient Navigators for Colon Cancer Screening
Icahn School of Medicine at Mount Sinai
NCT02226107
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
Corewell Health West
NCT00467922
Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy
Washington University School of Medicine
NCT05427214
CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer
David Bajor, MD
NCT02861300
Clinical Trial in Patients With Metastatic Colorectal Cancer
Mast Therapeutics
NCT00081627
Promoting Physical Activity After Colorectal Cancer
The Miriam Hospital
NCT00230646
Hybrid APC Assisted EMR for Large Colon Polyps
Milton S. Hershey Medical Center
NCT03390907
Sleep Coach: A Mobile App to Address Insomnia Symptoms Among Cancer Survivors
University of Michigan Rogel Cancer Center
NCT04827459
Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy
UNC Lineberger Comprehensive Cancer Center
NCT01789983
Genetic Investigation of Solid Tumors Cohort
Scripps Translational Science Institute
NCT01005225
Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies
Novita Pharmaceuticals
NCT03199586
Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance
National Human Genome Research Institute (NHGRI)
NCT02767986
Clinical and Translational Study of STA-9090
Memorial Sloan Kettering Cancer Center
NCT01111838
Cellular Immune Augmentation in Colon and Rectal Cancer
University of California, Irvine
NCT00257322
Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer
National Cancer Institute (NCI)
NCT03384316
Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers
National Cancer Institute (NCI)
NCT03801915
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
St. Luke's-Roosevelt Hospital Center
NCT01163552
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 26 |
| Phase 2 | 11 |
| Phase 3 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Colon Cancer Trial Landscape
99 indexed Colon Cancer studies · 34 recruiting (34%).
Phase mix: 4 late (III/IV) vs 37 early (I/II).
Top sponsor: National Cancer Institute (NCI) (6 trials), 9 others listed. 49 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Colon Cancer?
PlainTrial tracks 99 US clinical trials for Colon Cancer, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Colon Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.