Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 38 recruiting now official registry

Spinal Cord Injury clinical trials

Every US clinical trial registered for Spinal Cord Injury — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

100 US clinical trials · 38 currently recruiting

The research picture

Spinal Cord Injury has 100 registered US clinical trials, 38 of them open to new participants right now — about 38% of the total.

38
recruiting participants now
38%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
15
top sponsor: VA Office of Research and Development

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 1,500 participants

Spinal Cord Injury Registry - North American Clinical Trials Network

Robert G. Grossman, MD

NCT00178724

RECRUITING NA 808 participants

Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic

VA Office of Research and Development

NCT06529094

RECRUITING 260 participants

The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

AO Foundation, AO Spine

NCT06839300

RECRUITING NA 132 participants

Virtual Peer Coaching in Manual Wheelchair Skills

University of Pittsburgh

NCT06295146

RECRUITING 100 participants

Male Fertility Program

University of Miami

NCT01467869

RECRUITING 100 participants

mSCI: Mobile Health App for Veterans With SCI and Caregivers

University of Pittsburgh

NCT07269977

RECRUITING Phase 4 100 participants

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

John D. Dingell VA Medical Center

NCT02922894

RECRUITING 90 participants

Studying Rehabilitation Treatments Using Video to Improve Recovery for Adults With Physical Disabilities

Ohio State University

NCT07092293

RECRUITING NA 86 participants

Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

VA Office of Research and Development

NCT05157282

RECRUITING NA 76 participants

SCI&U Peer Health Coaching Program for Individuals Newly Discharged From Inpatient Rehabilitation

University of Toronto

NCT06677905

RECRUITING Early Phase 1 64 participants

Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis

Northwell Health

NCT04755699

RECRUITING NA 60 participants

Clinical Outcome Assessment for AT & BCI

Shirley Ryan AbilityLab

NCT07407725

RECRUITING NA 60 participants

Neuromodulation After Spinal Cord Injury to Improve Limb Function

State University of New York at Buffalo

NCT06815601

RECRUITING NA 54 participants

Improve Dynamic Lateral Balance of Humans With SCI

Shirley Ryan AbilityLab

NCT02991248

RECRUITING Phase 1 36 participants

CE-STAND: Cervical Epidural STimulation After Neurologic Damage

University of Minnesota

NCT06410001

RECRUITING NA 30 participants

Cortical Recording and Stimulating Array Brain-Machine Interface

Michael Boninger

NCT01894802

RECRUITING NA 30 participants

Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait

Brooks Rehabilitation

NCT07164846

RECRUITING NA 24 participants

Exoskeleton and Spinal Cord Stimulation for SCI

Kessler Foundation

NCT03096197

RECRUITING NA 24 participants

Improving Bladder Function in SCI by Neuromodulation

University of California, Los Angeles

NCT02331979

RECRUITING Phase 2 21 participants

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

North Florida Foundation for Research and Education

NCT04460872

RECRUITING NA 20 participants

Autonomic Effects of Stimulation in SCI

VA Office of Research and Development

NCT05664646

RECRUITING NA 20 participants

Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury

Jason Carmel

NCT06867809

RECRUITING Phase 2 20 participants

CBD for Lower Urinary Tract Dysfunction in Spinal Cord Injury

University of Wisconsin, Madison

NCT06840899

RECRUITING Early Phase 1 16 participants

Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury

University of Mississippi Medical Center

NCT06274021

RECRUITING NA 16 participants

Exciflex for Chronic Wound Therapy

VA Office of Research and Development

NCT04887688

RECRUITING NA 15 participants

Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)

Medical University of South Carolina

NCT07179822

RECRUITING 15 participants

Reliability and Validity of the PReFS

Baylor University

NCT07280923

RECRUITING Early Phase 1 15 participants

Testosterone and Neural Function

VA Office of Research and Development

NCT06130449

RECRUITING NA 12 participants

At-Home Genital Nerve Stimulation for SCI Bowel

MetroHealth Medical Center

NCT06836739

RECRUITING NA 12 participants

Self-balancing Personal Exoskeleton for SCI (WINY)

Wandercraft

NCT07222033

RECRUITING Phase 1 12 participants

Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury

HealthPartners Institute

NCT07384052

RECRUITING NA 12 participants

Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction

The University of Texas Health Science Center, Houston

NCT07213986

RECRUITING Early Phase 1 11 participants

MEP Up-conditioning to Target Corticospinal Plasticity

Medical University of South Carolina

NCT06989905

RECRUITING Phase 2 10 participants

Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury

Medical College of Wisconsin

NCT06723561

RECRUITING Phase 1 10 participants

A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury

Lineage Cell Therapeutics

NCT06841770

RECRUITING NA 10 participants

VR Mindfulness Training for Veterans With SCI

VA Office of Research and Development

NCT06587607

RECRUITING NA 10 participants

A Neuroprosthesis for Seated Posture and Balance

VA Office of Research and Development

NCT01474148

RECRUITING NA 10 participants

Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

VA Office of Research and Development

NCT05926596

ACTIVE NOT RECRUITING NA 125 participants

AIH-induced Walking Recovery After Subacute SCI

Spaulding Rehabilitation Hospital

NCT02632422

ACTIVE NOT RECRUITING NA 35 participants

Integrated Tele-exercise for Individuals With Spinal Cord Injury

Drexel University

NCT05360719

ACTIVE NOT RECRUITING NA 30 participants

C-Brace II Spinal Cord Injury

Shirley Ryan AbilityLab

NCT03930056

ACTIVE NOT RECRUITING NA 10 participants

Electrical Stimulation for Continence After Spinal Cord Injury

Palo Alto Veterans Institute for Research

NCT02978638

ACTIVE NOT RECRUITING NA 10 participants

Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury

MetroHealth Medical Center

NCT00583804

ACTIVE NOT RECRUITING NA 3 participants

Intelligent Spine Interface, Clinical (ISI-C)

Rhode Island Hospital

NCT04302259

COMPLETED 1,000 participants

Perceived Barriers to Exercise in Individuals Living With Spinal Cord Injury

University of California, Irvine

NCT00786786

COMPLETED 610 participants

Magnetic Resonance Imaging Studies of Motor and Thought Processes

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001361

COMPLETED Phase 3 213 participants

Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury

Acorda Therapeutics

NCT00041717

COMPLETED Phase 2 200 participants

Treadmill Training for Spinal Cord Injury

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00006429

COMPLETED 177 participants

Measurement of Autonomic Cardiovascular Integrity in Persons With SCI

James J. Peters Veterans Affairs Medical Center

NCT01758692

COMPLETED NA 177 participants

Power Over Pain (POP) Study

University of Washington

NCT01800604

COMPLETED 170 participants

Cardiovascular Disease Study

VA Office of Research and Development

NCT00857194

COMPLETED NA 148 participants

Maintenance of Shoulder Health and Function After Spinal Cord Injury

Rancho Research Institute

NCT02135978

COMPLETED 146 participants

Baseline Cardiovascular Measurements in Pediatric Spinal Cord Injury

Shriners Hospitals for Children

NCT01599455

COMPLETED Phase 3 120 participants

Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.

Elan Pharmaceuticals

NCT00047580

COMPLETED NA 94 participants

Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

Oregon Health and Science University

NCT02878850

COMPLETED 94 participants

MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI

US Department of Veterans Affairs

NCT00561782

COMPLETED 93 participants

Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)

University of Washington

NCT00947999

COMPLETED 92 participants

A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences

James J. Peters Veterans Affairs Medical Center

NCT03023163

COMPLETED NA 81 participants

Re-Inventing Yourself After Spinal Cord Injury

Craig Hospital

NCT01633164

COMPLETED NA 73 participants

Treatment of Sleep-disordered Breathing in Patients With SCI

VA Office of Research and Development

NCT02830074

COMPLETED Phase 2 72 participants

Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury

Tanabe Pharma America

NCT04683848

COMPLETED NA 67 participants

Virtual Walking for Neuropathic Pain in Spinal Cord Injury

University of Alabama at Birmingham

NCT01884662

COMPLETED 62 participants

Wheelchair Mobility Assessment of Individuals With Spinal Cord Injury

University of Miami

NCT01204047

COMPLETED Phase 2 60 participants

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

Northwestern University

NCT02325414

COMPLETED NA 48 participants

Improving Hand and Arm Function After Spinal Cord Injury (SCI)

University of Miami

NCT01143597

COMPLETED Phase 1 48 participants

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

Vertex Pharmaceuticals Incorporated

NCT00500812

COMPLETED Phase 2 40 participants

Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury

US Department of Veterans Affairs

NCT00755079

COMPLETED NA 38 participants

Comparison of Two Psycho-educational Family Group Interventions for Persons With SCI and Their Caregivers

St. Luke's Rehabilitation Institute

NCT02161913

COMPLETED NA 37 participants

Enhancing Self-Efficacy for Caregivers of Family Members With Spinal Cord Injury

Craig Hospital

NCT02392052

COMPLETED NA 34 participants

Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury

University of Michigan

NCT00735670

COMPLETED Phase 2 34 participants

Safety and Efficacy of L-NAME and Midodrine to Increase MAP

US Department of Veterans Affairs

NCT00835224

COMPLETED 31 participants

Follow up Study of Diaphragm Pacing for Patients With High Tetraplegia

Craig Hospital

NCT01815554

COMPLETED Phase 2 26 participants

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial

Brigham and Women's Hospital

NCT02218203

COMPLETED Phase 2 25 participants

12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)

Northwestern University

NCT02025179

COMPLETED Phase 2 23 participants

Fenofibrate Treatment in SCI

VA Office of Research and Development

NCT02455336

COMPLETED 20 participants

Experimental Evaluation of Wheelchair-Mounted Robotic Arms

University of South Florida

NCT01652352

COMPLETED NA 20 participants

Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation

The Cleveland Clinic

NCT01539109

COMPLETED Phase 4 19 participants

Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.

Craig Hospital

NCT00320281

COMPLETED NA 19 participants

Development and Feasibility of an Internet Intervention for Adults With Spinal Cord Injury to Prevent Pressure Ulcers

University of Virginia

NCT01885962

COMPLETED NA 19 participants

Development of Low Cost Devices to Increase Access to Treadmill Training

Shirley Ryan AbilityLab

NCT02560506

COMPLETED Phase 2 18 participants

Electrical Control of Bladder in Spinal Cord Injury Patients

US Department of Veterans Affairs

NCT00011570

COMPLETED NA 18 participants

Virtual Sailing Simulator in Individuals With Spinal Cord Injury

Hugo W. Moser Research Institute at Kennedy Krieger

NCT01491789

COMPLETED NA 18 participants

Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)

University of Miami

NCT01201759

COMPLETED NA 15 participants

Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury

Spaulding Rehabilitation Hospital

NCT03267212

COMPLETED 15 participants

Veteran-Centered Outcomes Using Qualitative and Quantitative Methods

US Department of Veterans Affairs

NCT00333580

COMPLETED Phase 2 12 participants

Testosterone and Long Pulse Stimulation After SCI

VA Office of Research and Development

NCT03345576

COMPLETED Phase 2 12 participants

Effects of Acute SCI on Colonic Motility & Tone

US Department of Veterans Affairs

NCT00013312

COMPLETED Phase 4 12 participants

Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)

Thomas J. Schnitzer

NCT00826228

COMPLETED NA 11 participants

Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury

Spaulding Rehabilitation Hospital

NCT02865343

COMPLETED NA 10 participants

Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury

VA Office of Research and Development

NCT04971408

COMPLETED NA 10 participants

Treating Cognitive Deficits in Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center

NCT03037879

COMPLETED Phase 2 10 participants

24hr Effects of Tiotropium Bromide in Tetraplegia

James J. Peters Veterans Affairs Medical Center

NCT02586649

COMPLETED NA 10 participants

Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation

Shirley Ryan AbilityLab

NCT02104622

COMPLETED NA 7 participants

Restoring Arm and Hand Function With Non-invasive Spinal Stimulation

NeuroEnabling Technologies

NCT01906424

COMPLETED Phase 2 6 participants

Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury.

VA Office of Research and Development

NCT05008484

COMPLETED Phase 1 6 participants

Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury

Kessler Foundation

NCT01355549

COMPLETED NA 5 participants

Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury

University of Louisville

NCT02037620

COMPLETED 5 participants

Home/Work, Community Mobility Skills in the ReWalk Exoskeleton in Persons With SCI

James J. Peters Veterans Affairs Medical Center

NCT02118194

COMPLETED Phase 2 4 participants

Neuromodulation Techniques After SCI

VA Office of Research and Development

NCT04241250

COMPLETED NA 1 participants

Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury

University of Louisville

NCT02154412

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 17
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Spinal Cord Injury Trial Landscape

ClinicalTrials.gov lists 100 US studies indexed under Spinal Cord Injury, and 38 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Spinal Cord Injury shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Spinal Cord Injury is led by VA Office of Research and Development with 15 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Spinal Cord Injury?

PlainTrial tracks 100 US clinical trials for Spinal Cord Injury, of which 38 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Spinal Cord Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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