National Human Genome Research Institute (NHGRI)

185 total trials 30 currently recruiting 143 completed

National Human Genome Research Institute (NHGRI) sponsors 185 registered US clinical trials on ClinicalTrials.gov, 30 of them currently recruiting, and 143 completed. 0 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Proteus Syndrome, with 3 trials.

Trial Pipeline

185 total, page 1 of 4

RECRUITING

Deciphering the Genetic Architecture of Autoimmune Diseases

NCT06948110

RECRUITING

Observational Study of Advanced Data Analytics in Genetic Conditions

NCT05657405

RECRUITING Phase 2

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

NCT06664814

RECRUITING NA

Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers

NCT06552754

RECRUITING

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

NCT06944067

RECRUITING

Childhood-Onset Essential Hypertension Natural History Study

NCT06778239

RECRUITING

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

NCT06092346

RECRUITING

Caregiving Networks Across Disease Context and the Life Course

NCT05007990

RECRUITING Phase 2

MK-7075 (Miransertib) in Proteus Syndrome

NCT04316546

RECRUITING

Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity

NCT04419870

RECRUITING NA

IDENTIFY Study: Natural History of Maternal Neoplasia

NCT04049604

RECRUITING Phase 1

A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

NCT03952637

RECRUITING

Longitudinal Studies of Patient With FPDMM

NCT03854318

RECRUITING

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

NCT02890342

RECRUITING

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

NCT02450851

RECRUITING

Genomic Services Research Program

NCT02595957

RECRUITING

Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation

NCT02089789

RECRUITING

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

NCT01780168

RECRUITING

A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases

NCT01417533

RECRUITING

Genome Medical Sequencing for Gene Discovery

NCT01087320

RECRUITING

Studies of Skin Microbes in Healthy People and in People With Skin Conditions

NCT00605878

RECRUITING

Clinical and Laboratory Study of Methylmalonic Acidemia

NCT00078078

RECRUITING

Study of Chediak-Higashi Syndrome

NCT00005917

RECRUITING

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

NCT00029965

RECRUITING

Study of Alkaptonuria

NCT00005909

RECRUITING

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

NCT00001456

RECRUITING

Study of Proteus Syndrome and Related Congenital Disorders

NCT00001403

RECRUITING

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

NCT00001373

RECRUITING

Use of Cysteamine in the Treatment of Cystinosis

NCT00359684

RECRUITING

Diagnosis and Treatment of Patients With Inborn Errors of Metabolism

NCT00369421

ACTIVE NOT RECRUITING

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

NCT00410241

ACTIVE NOT RECRUITING

Analysis of Specimens From Individuals With Pulmonary Fibrosis

NCT00084305

ACTIVE NOT RECRUITING

Natural History Study of Smith-Magenis Syndrome

NCT00013559

COMPLETED

Care Choreographies and the Making of the Psychosocial in Genetic Counseling

NCT06280833

COMPLETED

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History Study

NCT05484882

COMPLETED

Genetic and Social Network Correlates of Rheumatoid Arthritis Outcomes in Hispanic Populations: A Prospective Study

NCT05457816

COMPLETED

Living With Sickle Cell Disease in the COVID-19 Pandemic

NCT04417673

COMPLETED

Genetics of COVID-19 Susceptibility and Manifestations

NCT04371432

COMPLETED

New Approaches for Empowering Studies of Asthma in Populations of African Descent

NCT03937804

COMPLETED

Mapping Institutional Identities and the Production of Ethics

NCT03983863

COMPLETED

Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing

NCT03605004

COMPLETED

Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)

NCT03478839

COMPLETED NA

Is it Feasible?: Self-Affirmation for Hereditary Breast and Ovarian Cancer Genetic Counseling

NCT03225170

COMPLETED

Pregnant Women s Views About the Ethics of Prenatal Whole Genome Sequencing

NCT03105492

COMPLETED

Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care

NCT03167450

COMPLETED

Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

NCT02767986

COMPLETED NA

New Technology and Child Health

NCT02622035

COMPLETED Phase 1

Dose Finding Trial of MK-7075 in Children and Adults With Proteus Syndrome

NCT02594215

COMPLETED

Are Genetic Counselors Screening for Adolescent Suicide Risk?

NCT02486120

COMPLETED Phase 2

Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation

NCT02428296

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What the Pipeline for National Human Genome Research Institute (NHGRI) Shows

According to the ClinicalTrials.gov registry, National Human Genome Research Institute (NHGRI) is linked to 185 US clinical trials across every stage of research activity. Of those, 30 studies are currently recruiting, about 16% of the sponsor's indexed portfolio, and 143 are already marked complete, representing roughly 77% of the total.

The phase mix for National Human Genome Research Institute (NHGRI) reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 18 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Human Genome Research Institute (NHGRI) is Proteus Syndrome with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.