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NCT06697184 · ClinicalTrials.gov registry record · Phase 1
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
A Phase 1 study of Chronic Lymphocytic Leukemia and CLL, sponsored by BeiGene.
- Active
- Registry status
- Phase 1
- Development phase
- 56
- Enrollment target
- 17
- Study locations
NCT06697184: Active Phase 1 study of Chronic Lymphocytic Leukemia and CLL, sponsored by BeiGene.
NCT06697184 is a Phase 1 study of Chronic Lymphocytic Leukemia and CLL that is active but no longer recruiting, run by BeiGene. The registered enrollment target is 56 participants, below the 182-participant average among 187 other Chronic Lymphocytic Leukemia trials with a reported enrollment target (69% lower). The trial reports 17 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06697184, a Phase 1 study of Chronic Lymphocytic Leukemia and CLL, is active but no longer recruiting, sponsored by BeiGene.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 56 participants
- Enrollment target
- 17
- Study locations
Study Summary
The purpose of this study is to establish the safety of novel dosing and ramp-up schedules for sonrotoclax in participants with hematological malignancies.
Primary Outcome
TLS will be defined by Howard criteria during the schedule-limiting toxicity (SLT) evaluation window
Conditions Studied
Interventions
- DRUG Zanubrutinib
- DRUG Sonrotoclax
Study Locations (17)
Other
- Chu Dijon - Dijon
- Chu Montpellier Hopital Saint Eloi - Montpellier
- Iuct Oncopole - Toulouse
- Queen Elizabeth Hospital - Birmingham
- St Jamess University Hospital - Leeds
Victoria
- Cabrini Hospital Malvern - Malvern East
- The Alfred Hospital - Melbourne
Western Australia
- Rockingham Hospital - Cooloongup
- Linear Clinical Research - Nedlands
Florida
- Moffitt Cancer Center - Tampa
Indiana
- Fort Wayne Medical Oncology and Hematology - Fort Wayne
Kansas
- The University of Kansas Cancer Center - Westwood
Massachusetts
- Dana Farber Cancer Institute - Boston
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2025-01-23 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 1 |
What the registry record for NCT06697184 still lists
NCT06697184 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 182-participant average among 187 other Chronic Lymphocytic Leukemia trials with a reported enrollment target (69% lower).
The record links to 2 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 2 interventions - of which Zanubrutinib is the first listed.
NCT06697184 lists 17 locations in 11 states (Other, Victoria, Western Australia).
Frequently Asked Questions
What is clinical trial NCT06697184 about?
NCT06697184 is a clinical study titled "A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.". The purpose of this study is to establish the safety of novel dosing and ramp-up schedules for sonrotoclax in participants with hematological malignancies.
What is the current status of trial NCT06697184?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 56 participants. The study started on 2025-01-23. Estimated completion is 2027-12-31.
What conditions does trial NCT06697184 study?
This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, CLL.
What interventions are being tested in trial NCT06697184?
The interventions under investigation include: Zanubrutinib (DRUG), Sonrotoclax (DRUG).
Who is sponsoring clinical trial NCT06697184?
This trial is sponsored by BeiGene, which has 65 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06697184 being conducted?
This trial has 17 study locations across Florida, Indiana, Kansas, Massachusetts, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Lymphocytic Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06697184's enrollment target sits among peer trials
56 95th of 187 higher than 93 of 187 other Chronic Lymphocytic Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Lymphocytic Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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