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ACTIVE NOT RECRUITING Phase 1

FT819 in Subjects With B-cell Malignancies

NCT04629729 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase I dose-finding study of FT819 as monotherapy and in combination with IL-2 in subjects with relapsed/refractory B-cell Lymphoma, Chronic Lymphocytic Leukemia and Precursor B-cell Acute Lymphoblastic Leukemia. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine
  • DRUG IL-2
  • DRUG Bendamustine
  • DRUG FT819

Study Locations (18)

California

  • UC Davis — Davis
  • Scripps Green Hospital — La Jolla
  • UCLA Ronald Reagan Medical Center — Los Angeles
  • Stanford Cancer Institute — Palo Alto

Florida

  • University of Florida — Gainesville
  • Mayo Florida — Jacksonville

Alabama

  • University of Alabama at Birmingham — Birmingham

Arizona

  • Mayo Arizona — Phoenix

Iowa

  • University of Iowa — Iowa City

Kansas

  • The University of Kansas Cancer Center — Westwood

Kentucky

  • Norton Cancer Institute, St. Matthews Campus — Louisville

Minnesota

  • Mayo Minnesota — Rochester

Trial Details

FieldValue
Enrollment Target 54 participants
Start Date 2021-07-12
Est. Completion 2039-09-30
Phase Phase 1

Sponsor

Fate Therapeutics

5 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04629729

The ClinicalTrials.gov registry entry for NCT04629729 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Fate Therapeutics, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04629729 reports 18 study locations spanning 14 distinct geographic areas — top geographies include California, Florida, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04629729 about?

NCT04629729 is a clinical study titled "FT819 in Subjects With B-cell Malignancies". This is a Phase I dose-finding study of FT819 as monotherapy and in combination with IL-2 in subjects with relapsed/refractory B-cell Lymphoma, Chronic Lymphocytic Leukemia and Precursor B-cell Acute Lymphoblastic Leukemia. The study will consist of a dose-escalation stage and an expansion stage whe...

What is the current status of trial NCT04629729?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 54 participants. The study started on 2021-07-12. Estimated completion is 2039-09-30.

What conditions does trial NCT04629729 study?

This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, Lymphoma, B-Cell, Precursor B-Cell Acute Lymphoblastic Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04629729?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), IL-2 (DRUG), Bendamustine (DRUG), FT819 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04629729?

This trial is sponsored by Fate Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04629729 being conducted?

This trial has 18 study locations across Alabama, Arizona, California, Florida, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial