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ClinicalTrials.gov 65 recruiting now official registry

Chronic Lymphocytic Leukemia clinical trials

65 of 189 indexed Chronic Lymphocytic Leukemia trials are currently recruiting.

189 US clinical trials · 65 currently recruiting

Chronic Lymphocytic Leukemia is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 141 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

The research picture

Chronic Lymphocytic Leukemia has 189 registered US clinical trials, 65 of them open to new participants right now, about 34% of the total.

65
recruiting participants now
34%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
15
top sponsor: M.D. Anderson Cancer Center
Phase 167Phase 274Phase 325Phase 42

Active & Recent Trials

189 total, page 4 of 4

COMPLETED Phase 1 64 participants

Fludarabine, Rituximab, and Lenalidomide in Minimally Treated/Untreated Patients With Chronic Lymphocytic Leukemia (CLL)

SCRI Development Innovations

NCT00536341

COMPLETED Phase 1 60 participants

Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT00880815

COMPLETED Phase 2 60 participants

FCR Plus Sargramostim (GM-CSF) as Frontline Therapy for Symptomatic Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT00381004

COMPLETED Phase 2 50 participants

Phase II Safety and Efficacy Study of Single-agent AT-101 in Patients With Relapsed or Refractory B-cell Malignancies

Ascenta Therapeutics

NCT00275431

COMPLETED NA 50 participants

A Quality Improvement Approach to the Management of Chronic Lymphocytic Leukemia

Duke University

NCT02619604

COMPLETED Phase 1 49 participants

A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

AbbVie

NCT01682616

COMPLETED Phase 1 49 participants

IMGN529 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

ImmunoGen

NCT01534715

COMPLETED Phase 2 45 participants

Lenalidomide (Revlimid) in Chronic Lymphocytic Leukemia (CLL)

M.D. Anderson Cancer Center

NCT00267059

COMPLETED Phase 1 43 participants

Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors

National Cancer Institute (NCI)

NCT01326702

COMPLETED Phase 2 41 participants

Arsenic Trioxide in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT00193518

COMPLETED Phase 1 40 participants

Phase I/II Study of Genasense in Patients With Chronic Lymphocytic Leukemia

Genta Incorporated

NCT00021749

COMPLETED Phase 1 38 participants

Blinded Cross-Over Bioequivalence (BE) Trial of Luitpold Azacitidine vs Vidaza

American Regent

NCT01290302

COMPLETED Phase 1 36 participants

Etanercept and Rituximab in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

John Byrd

NCT00201682

COMPLETED Phase 1 36 participants

Assess the Oral Bioavailability of New ABT-263 Formulations

Abbott

NCT00743028

COMPLETED Phase 2 34 participants

Study of Bendamustine/Rituxan Induction Chemotherapy With Revlimid Maintenance for Relapsed/Refractory CLL and SLL

University of Wisconsin, Madison

NCT00974233

COMPLETED Phase 2 33 participants

Reduced Intensity Double Umbilical Cord Blood Transplantation

Massachusetts General Hospital

NCT01408563

COMPLETED Phase 1 27 participants

Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

TG Therapeutics

NCT02535286

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 2 25 participants

Reduced Intensity Conditioning Transplant Using Haploidentical Donors

Northside Hospital

NCT02581007

COMPLETED NA 25 participants

DISCO Application for the Improvement of Financial Outcomes in Patients With Hematologic Cancer

Barbara Ann Karmanos Cancer Institute

NCT04282343

COMPLETED Phase 2 24 participants

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

MorphoSys

NCT02639910

COMPLETED Phase 1 23 participants

Phase I Trial of Anti-CD74 (hLL1) Antibody Therapy in B Cell Malignancies

Weill Medical College of Cornell University

NCT00504972

COMPLETED 23 participants

MEOI and HRQoL in CLL Patients Treated With BTKis

AstraZeneca

NCT04938141

COMPLETED Phase 1 23 participants

Safety Study of CAT-8015 to Treat Advanced B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia (NHL or CLL)

MedImmune

NCT01030536

COMPLETED Phase 2 23 participants

A Pilot Study of OSI-461 in Patients With Chronic Lymphocytic Leukemia (CLL)

Astellas Pharma

NCT00073489

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

COMPLETED Phase 1 16 participants

Phase 1 Study of TG02 Citrate in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

Tragara Pharmaceuticals

NCT01699152

COMPLETED Phase 2 16 participants

Perifosine in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Daphne Friedman

NCT00873457

COMPLETED Phase 1 16 participants

Pharmacodynamic (PD) Study of Intranodal Adenovirus-CD154 (Ad-ISF35) in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

University of California, San Diego

NCT00850057

COMPLETED Phase 2 15 participants

Alternating Thalidomide and Lenalidomide Therapy Plus Rituximab (ThRiL) as Initial Treatment for Patients With CLL

Weill Medical College of Cornell University

NCT01125176

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

COMPLETED Phase 1 12 participants

A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-263 (Navitoclax).

Abbott

NCT01021358

COMPLETED Phase 1 11 participants

8-Chloro-Adenosine in Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT00714103

COMPLETED Phase 2 8 participants

Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02530515

COMPLETED Phase 1 7 participants

Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

David Bond, MD

NCT03892044

COMPLETED Phase 2 6 participants

Letermovir for the Prevention of Cytomegalovirus Reactivation in Patients With Hematological Malignancies Treated With Alemtuzumab

Ohio State University Comprehensive Cancer Center

NCT04312841

COMPLETED Phase 1 6 participants

A Study of BNC105P Combined With Ibrutinib

Dartmouth-Hitchcock Medical Center

NCT03454165

COMPLETED Phase 2

Study of Talabostat and Rituximab in Advanced Chronic Lymphocytic Leukemia (CLL)

Point Therapeutics

NCT00086203

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Phase Distribution

PhaseTrial count
Phase 1 67
Phase 2 74
Phase 3 25
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia Trial Landscape

189 indexed Chronic Lymphocytic Leukemia studies · 65 recruiting (34%).

Phase mix: 27 late (III/IV) vs 141 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (15 trials), 9 others listed. 39 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia?

PlainTrial tracks 189 US clinical trials for Chronic Lymphocytic Leukemia, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.