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NCT07124078 · ClinicalTrials.gov registry record · Phase 2
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
A Phase 2 study of Chronic Graft Versus Host Disease, sponsored by Incyte Corporation.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 20
- Study locations
NCT07124078 is a Phase 2 study of Chronic Graft Versus Host Disease that is actively recruiting participants, run by Incyte Corporation. The registered enrollment target is 60 participants, below the 114-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (47% lower). The trial reports 20 study locations across 9 states.
The verdict
NCT07124078, a Phase 2 study of Chronic Graft Versus Host Disease, is actively recruiting participants, sponsored by Incyte Corporation.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study will be conducted to compare Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy.
Conditions Studied
Interventions
- DRUG INCA034176
- DRUG Best available Treatment (BAT)
Study Locations (20)
Other
- Hôpital Universitaire Des Enfants Reine Fabiola - Brussels
- Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc - Woluwe-Saint-Lambert
- Charite Campus Virchow - Berlin
- Klinikum Der Johann Wolfgang Goethe-Universitaet - Frankfurt am Main
- Universitaetsklinikum Freiburg Zentrum Fuer Kinderheilkunde- Und Jugendmedizin Klinik Iv: Paediatris - Freiburg im Breisgau
- Universitaetsklinikum Hamburg-Eppendorf - Hamburg
- Medizinische Hochschule Hannover (Mhh) - Zentrum Fuer Kinderheilkunde Und Jugendmedizin - Klinik Fue - Hanover
- University Hospital Regensburg - Regensburg
- Irccs - Aou Di Bologna - Sant'Orsola Malpighi - Bologna
- Irccs Istituto G. Gaslini, Universita Di Genova - Genova
- Fondazione Irccs San Gerardo Dei Tintori - Monza
California
- City of Hope Medical Center - Duarte
- Lucile Packard Child Hospital End - Stanford
District of Columbia
- Childrens National Medical Center - Washington D.C.
Florida
- Adventhealth Pediatric Cellular Therapy and Blood and Marrow Transplant - Orlando
Georgia
- Childrens Healthcare of Atlanta - Atlanta
New York
- Memorial Sloan Kettering Cancer Center - New York
North Carolina
- Levine Cancer Institute - Charlotte
Pennsylvania
- Childrens Hospital of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-03-31 |
| Est. Completion | 2029-07-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07124078
The ClinicalTrials.gov registry entry for NCT07124078 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 114-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (47% lower). The listed sponsor is Incyte Corporation, which has 239 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Chronic Graft Versus Host Disease appearing as the primary indexed condition, and to 2 interventions - of which INCA034176 is the first listed.
NCT07124078 reports 20 study locations spanning 9 distinct geographic areas - top geographies include Other, California, District of Columbia.
Frequently Asked Questions
What is clinical trial NCT07124078 about?
NCT07124078 is a clinical study titled "A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)". This study will be conducted to compare Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy.
What is the current status of trial NCT07124078?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-03-31. Estimated completion is 2029-07-31.
What conditions does trial NCT07124078 study?
This clinical trial studies the following conditions: Chronic Graft Versus Host Disease.
What interventions are being tested in trial NCT07124078?
The interventions under investigation include: INCA034176 (DRUG), Best available Treatment (BAT) (DRUG).
Who is sponsoring clinical trial NCT07124078?
This trial is sponsored by Incyte Corporation, which has 239 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07124078 being conducted?
This trial has 20 study locations across California, District of Columbia, Florida, Georgia, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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