Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)

NCT02959944 · View on ClinicalTrials.gov ↗

Study Summary

To evaluate the safety and efficacy of ibrutinib in combination with prednisone in subjects with newly diagnosed moderate to severe cGVHD.

Interventions

  • DRUG Placebo
  • DRUG Prednisone
  • DRUG ibrutinib

Study Locations (20)

California

  • LPCH Stanford /ID# 1140-1128 — Palo Alto
  • Ucsf /Id# 1140-0003 — San Francisco
  • Stanford University/Stanford Cancer Center, Pasteur Drive /ID# 1140-0400 — Stanford

Massachusetts

  • Massachusetts General Hospital Cancer Center /ID# 1140-0020 — Boston
  • Boston Childrens Hospital /ID# 1140-1615 — Boston
  • Dana-Farber Cancer Institute /ID# 1140-0349 — Boston

Florida

  • Jackson Memorial Hospital, University of Miami /ID# 1140-0647 — Miami
  • Florida Hospital Cancer Institute/Adventist Health System/Sunbelt, Inc /ID# 1140-1121 — Orlando

Georgia

  • Emory University, Winship Cancer Institute /ID# 1140-0033 — Atlanta
  • Emory University/Winship Cancer Institute /ID# 1140-1179 — Atlanta

Illinois

  • University of Chicago /ID# 1140-0126 — Chicago
  • Loyola University /ID# 1140-0713 — Maywood

Kentucky

  • University of Kentucky /ID# 1140-1140 — Lexington
  • University of Louisville Hospital /ID# 1140-1131 — Louisville

Arizona

  • Arizona Oncology - Scottsdale - Cancer Transplant Institute Location /ID# 1140-1120 — Scottsdale

Colorado

  • UCHSC Anschultz Cancer Pavilion /ID# 1140-0068 — Aurora

Trial Details

FieldValue
Enrollment Target 193 participants
Start Date 2017-05-11
Est. Completion 2021-07-12
Phase Phase 3

Sponsor

Pharmacyclics

13 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02959944

The ClinicalTrials.gov registry entry for NCT02959944 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 193 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pharmacyclics, which has 13 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Graft Versus Host Disease appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02959944 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Massachusetts, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02959944 about?

NCT02959944 is a clinical study titled "Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)". To evaluate the safety and efficacy of ibrutinib in combination with prednisone in subjects with newly diagnosed moderate to severe cGVHD.

What is the current status of trial NCT02959944?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 193 participants. The study started on 2017-05-11. Estimated completion is 2021-07-12.

What conditions does trial NCT02959944 study?

This clinical trial studies the following conditions: Chronic Graft Versus Host Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02959944?

The interventions under investigation include: Placebo (DRUG), Prednisone (DRUG), ibrutinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02959944?

This trial is sponsored by Pharmacyclics, which has 13 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02959944 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial