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NCT02611180 · ClinicalTrials.gov registry record
Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
A clinical trial of Chronic Graft Versus Host Disease and Acute-graft-versus-host Disease, sponsored by Washington University School of Medicine.
- Active
- Registry status
- 22
- Enrollment target
- 1
- Study location
NCT02611180 is a study of Chronic Graft Versus Host Disease and Acute-graft-versus-host Disease that is active but no longer recruiting, run by Washington University School of Medicine. The registered enrollment target is 22 participants, below the 116-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state.
The verdict
NCT02611180, a study of Chronic Graft Versus Host Disease and Acute-graft-versus-host Disease, is active but no longer recruiting, sponsored by Washington University School of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- 22 participants
- Enrollment target
- 1
- Study location
Study Summary
Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign antigens, they migrate to secondary lymphoid organs, where the processed antigens are presented to T cells. Various DC subsets with unique cell lineages, surface protein markers, and tissue localization determinants have been identified. For example, Langerhans cells (LCs) and interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the skin. Though both are expressed in the skin, they differ with respect to their origin and surface protein content and can activate distinct types of immune responses. They may also have different specificities for the capture of antigens and presentation to circulating T cells. To date, it is unknown what role, if any, the different DC populations that reside or repopulate in the skin play in the development and progression of skin graft-versus-host disease (GVHD) following bone marrow transplant.
Conditions Studied
Interventions
- PROCEDURE Peripheral blood draw
- PROCEDURE Skin punch biopsy
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2015-04-30 |
| Est. Completion | 2027-04-30 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02611180
The ClinicalTrials.gov registry entry for NCT02611180 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 116-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (81% lower). The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Chronic Graft Versus Host Disease appearing as the primary indexed condition, and to 2 interventions - of which Peripheral blood draw is the first listed.
NCT02611180 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT02611180 about?
NCT02611180 is a clinical study titled "Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease". Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign antigens, they migrate to secondary lymphoid organs, where the processed antigens are presented to T cells. Various DC s...
What is the current status of trial NCT02611180?
This trial is currently active not recruiting. The enrollment target is 22 participants. The study started on 2015-04-30. Estimated completion is 2027-04-30.
What conditions does trial NCT02611180 study?
This clinical trial studies the following conditions: Chronic Graft Versus Host Disease, Acute-graft-versus-host Disease, Chronic GVHD, Acute GVHD.
What interventions are being tested in trial NCT02611180?
The interventions under investigation include: Peripheral blood draw (PROCEDURE), Skin punch biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT02611180?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02611180 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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