Pharmacyclics

54 total trials 46 completed

Pharmacyclics sponsors 54 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 46 completed. 11 of these trials are in Phase 3-4 (later-stage) and 42 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Multiple Myeloma, with 3 trials.

Trial Pipeline

54 total, page 1 of 2

COMPLETED Phase 1

Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)

NCT03790332

COMPLETED Phase 3

Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (MCL)

NCT03112174

COMPLETED Phase 3

Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)

NCT02959944

COMPLETED Phase 3

Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

NCT02947347

COMPLETED Phase 2

Ibrutinib Plus Venetoclax in Subjects With Treatment-naive Chronic Lymphocytic Leukemia /Small Lymphocytic Lymphoma (CLL/SLL)

NCT02910583

TERMINATED Phase 1

Study of Ibrutinib in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma

NCT02548962

COMPLETED Phase 1

Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors

NCT02599324

COMPLETED

informCLL™: A Disease Registry for Patients With Chronic Lymphocytic Leukemia

NCT02582879

COMPLETED Phase 1

A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas

NCT02401048

COMPLETED Phase 3

Study of Ibrutinib vs Placebo, in Combination With Nab-paclitaxel and Gemcitabine, in the First Line Treatment of Patients With Metastatic Pancreatic Adenocarcinoma (RESOLVE)

NCT02436668

COMPLETED Phase 1

A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors

NCT02403271

TERMINATED Phase 2

Study of Ibrutinib in Subjects With Acute Myeloid Leukemia

NCT02351037

COMPLETED Phase 3

A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

NCT02264574

COMPLETED Phase 1

Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Chronic Graft Versus Host Disease

NCT02195869

COMPLETED Phase 3

Ibrutinib With Rituximab in Adults With Waldenström's Macroglobulinemia

NCT02165397

COMPLETED Phase 1

Ibrutinib and Lenalidomide With Dose Adjusted EPOCH-R in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT02142049

COMPLETED Phase 1

Ibrutinib in Combination With Lenalidomide and Rituximab in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT02077166

COMPLETED Phase 3

Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT01724346

COMPLETED Phase 2

Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed/Refractory Marginal Zone Lymphoma

NCT01980628

COMPLETED Phase 1

Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple Myeloma

NCT01962792

COMPLETED Phase 2

Study of Ibrutinib in Combination With Rituximab in Previously Untreated Subjects With Follicular Lymphoma

NCT01980654

COMPLETED Phase 3

Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL

NCT01722487

COMPLETED Phase 2

A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion

NCT01744691

COMPLETED Phase 3

A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

NCT01578707

COMPLETED Phase 2

Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed or Relapsed and Refractory Multiple Myeloma

NCT01478581

COMPLETED Phase 2

Safety and Efficacy Study of a BTK Inhibitor in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma

NCT01325701

COMPLETED Phase 2

Safety and Efficacy of PCI-32765 in Participants With Relapsed/Refractory Mantle Cell Lymphoma (MCL)

NCT01236391

COMPLETED Phase 1

Safety and Tolerability Study of PCI-32765 Combined With Fludarabine/Cyclophosphamide/Rituximab (FCR) and Bendamustine/Rituximab (BR) in Chronic Lymphocytic Leukemia (CLL)

NCT01292135

COMPLETED Phase 1

Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLL

NCT01217749

COMPLETED Phase 1

A Safety and Tolerability Study of PCI-24781 in Subjects With Cancer

NCT01149668

COMPLETED Phase 2

Safety and Tolerability Study of PCI-32765 in B Cell Lymphoma and Chronic Lymphocytic Leukemia

NCT01109069

COMPLETED Phase 1

Safety of PCI-32765 in Chronic Lymphocytic Leukemia

NCT01105247

COMPLETED Phase 2

Study of Safety and Tolerability of PCI-27483 in Patients With Pancreatic Cancer Patients Receiving Treatment With Gemcitabine

NCT01020006

COMPLETED Phase 1

Study of the Safety and Tolerability of PCI-32765 in Patients With Recurrent B Cell Lymphoma

NCT00849654

COMPLETED Phase 1

Study of the Safety and Tolerability of PCI-24781 in Patients With Lymphoma

NCT00724984

COMPLETED Phase 1

Study of the Safety and Tolerability of Oral Capsule Form of PCI-24781 in Advanced Cancer Patients

NCT00562224

TERMINATED Phase 2

Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer

NCT00365183

TERMINATED Phase 2

Study of the Effect on Non-small Cell Lung Cancer of the Investigational Drug Motexafin Gadolinium When Used in Combination With Docetaxel (Taxotere)

NCT00373204

COMPLETED Phase 1

Study of Weekly Motexafin Gadolinium (MGd) for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT00290004

COMPLETED Phase 2

Study of Motexafin Gadolinium (MGd) for Second Line Treatment of Non-Small-Cell Lung Cancer

NCT00129844

COMPLETED Phase 1

Study of the Tolerability, Safety, and Pharmacokinetics of CRA-024781 in Cancer Patients

NCT00473577

COMPLETED Phase 1

A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC)

NCT00102505

TERMINATED Phase 2

Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT00100711

COMPLETED Phase 3

Radiation Therapy Plus Gadolinium Texaphyrin in Treating Patients With Brain Metastases

NCT00003563

COMPLETED Phase 2

Study of Motexafin Gadolinium for the Treatment of Renal Cell (Kidney) Cancer

NCT00134186

COMPLETED Phase 3

Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART)

NCT00054795

COMPLETED Phase 1

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer

NCT00120939

COMPLETED Phase 2

A Study of Motexafin Gadolinium for the Treatment of Relapsed or Refractory Multiple Myeloma

NCT00096837

COMPLETED Phase 1

Study of Motexafin Gadolinium and Docetaxel for Advanced Solid Tumors

NCT00080041

COMPLETED Phase 1

A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas

NCT00080054

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What the Pipeline for Pharmacyclics Shows

According to the ClinicalTrials.gov registry, Pharmacyclics is linked to 54 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 46 are already marked complete, representing roughly 85% of the total.

The phase mix for Pharmacyclics reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 42 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Pharmacyclics is Multiple Myeloma with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.