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NCT04431479 · ClinicalTrials.gov registry record

Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study

A clinical trial of Chronic Graft Versus Host Disease, sponsored by Fred Hutchinson Cancer Center.

Recruiting
Registry status
300
Enrollment target
10
Study locations

NCT04431479: Recruiting study of Chronic Graft Versus Host Disease, sponsored by Fred Hutchinson Cancer Center.

NCT04431479 is a study of Chronic Graft Versus Host Disease that is actively recruiting participants, run by Fred Hutchinson Cancer Center. The registered enrollment target is 300 participants, above the 106-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (183% higher). The trial reports 10 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04431479, a study of Chronic Graft Versus Host Disease, is actively recruiting participants, sponsored by Fred Hutchinson Cancer Center.

RECRUITING
Registry status
300 participants
Enrollment target
10
Study locations

Study Summary

This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and after treatment initiation may help doctors identify changes that may predict treatment response.

Primary Outcome

At the assessments, the 9 provider-reported National Institute of Health (NIH) organ severity scores (skin, eye, mouth, esophagus, upper gastrointestinal \[GI\], lower GI, liver, lung, and joint manifestations) will be collected reflecting disease activity in the past week. All scored items are single 4-7 point Likert scales. Based on past work, we anticipate it will take approximately 8 minutes to conduct the physical exam and record the relevant results. Pulmonary function testing results will

Conditions Studied

Chronic Graft Versus Host Disease

Interventions

  • PROCEDURE Biospecimen Collection
  • OTHER Quality-of-Life Assessment
  • OTHER Questionnaire Administration
  • OTHER Medical Chart Review

Study Locations (10)

Florida

  • University of Florida - Gainesville
  • Moffitt Cancer Center - Tampa

Massachusetts

  • Dana-Farber Harvard Cancer Center - Boston

Minnesota

  • University of Minnesota/Masonic Cancer Center - Minneapolis

New York

  • Roswell Park Cancer Institute - Buffalo

Ohio

  • Cleveland Clinic Foundation - Cleveland

Pennsylvania

  • UPMC Hillman Cancer Center - Pittsburgh

Tennessee

  • Vanderbilt University/Ingram Cancer Center - Nashville

Washington

  • Fred Hutch/University of Washington Cancer Consortium - Seattle

Trial Details

FieldValue
Enrollment Target 300 participants
Start Date 2020-06-29
Est. Completion 2026-08-02
Fred Hutchinson Cancer Center

483 total trials

What NCT04431479 shows while recruiting

NCT04431479 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, above the 106-participant average among 30 other Chronic Graft Versus Host Disease trials with a reported enrollment target (183% higher).

The record links to 1 condition, with Chronic Graft Versus Host Disease appearing as the primary indexed condition, and to 4 interventions - of which Biospecimen Collection is the first listed.

NCT04431479 lists 10 locations in 9 states (Florida, Massachusetts, Minnesota).

Frequently Asked Questions

What is clinical trial NCT04431479 about?

NCT04431479 is a clinical study titled "Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study". This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and ...

What is the current status of trial NCT04431479?

This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2020-06-29. Estimated completion is 2026-08-02.

What conditions does trial NCT04431479 study?

This clinical trial studies the following conditions: Chronic Graft Versus Host Disease.

What interventions are being tested in trial NCT04431479?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Quality-of-Life Assessment (OTHER), Questionnaire Administration (OTHER), Medical Chart Review (OTHER).

Who is sponsoring clinical trial NCT04431479?

This trial is sponsored by Fred Hutchinson Cancer Center, which has 483 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04431479 being conducted?

This trial has 10 study locations across Florida, Massachusetts, Minnesota, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Chronic Graft Versus Host Disease

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04431479's enrollment target sits among peer trials

300 3rd of 30 higher than 28 of 30 other Chronic Graft Versus Host Disease trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Chronic Graft Versus Host Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04431479

Source: ClinicalTrials.gov NCT04431479, the US trial registry maintained by the National Library of Medicine. NCT04431479 (mid enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.