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Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
NCT04431479 · View on ClinicalTrials.gov ↗
Study Summary
This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and after treatment initiation may help doctors identify changes that may predict treatment response.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Quality-of-Life Assessment
- OTHER Questionnaire Administration
- OTHER Medical Chart Review
Study Locations (10)
Florida
- University of Florida — Gainesville
- Moffitt Cancer Center — Tampa
Massachusetts
- Dana-Farber Harvard Cancer Center — Boston
Minnesota
- University of Minnesota/Masonic Cancer Center — Minneapolis
New York
- Roswell Park Cancer Institute — Buffalo
Ohio
- Cleveland Clinic Foundation — Cleveland
Pennsylvania
- UPMC Hillman Cancer Center — Pittsburgh
Tennessee
- Vanderbilt University/Ingram Cancer Center — Nashville
Washington
- Fred Hutch/University of Washington Cancer Consortium — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2020-06-29 |
| Est. Completion | 2026-08-02 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04431479
The ClinicalTrials.gov registry entry for NCT04431479 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Fred Hutchinson Cancer Center, which has 319 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Chronic Graft Versus Host Disease appearing as the primary indexed condition, and to 4 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04431479 reports 10 study locations spanning 9 distinct geographic areas — top geographies include Florida, Massachusetts, Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04431479 about?
NCT04431479 is a clinical study titled "Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study". This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and ...
What is the current status of trial NCT04431479?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2020-06-29. Estimated completion is 2026-08-02.
What conditions does trial NCT04431479 study?
This clinical trial studies the following conditions: Chronic Graft Versus Host Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04431479?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Quality-of-Life Assessment (OTHER), Questionnaire Administration (OTHER), Medical Chart Review (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04431479?
This trial is sponsored by Fred Hutchinson Cancer Center, which has 319 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04431479 being conducted?
This trial has 10 study locations across Florida, Massachusetts, Minnesota, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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